{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:41:18Z","timestamp":1791060078356,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T00:00:00Z","timestamp":1357171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"national program for clinical research","award":["PHRC 2005"],"award-info":[{"award-number":["PHRC 2005"]}]},{"name":"National Center on Hereditary Immune Deficiencies"},{"name":"Laboratoire Fran\u00e7ais du fractionnement et des Biotechnologies"},{"DOI":"10.13039\/100009430","name":"Baxter BioScience","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009430","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Treatment of common variable immunodeficiency disorders (CVID) is based on replacement therapy using intravenous (i.v.) or subcutaneous (s.c.) immunoglobulin (Ig)G. Interindividual variation of IgG dose is common. A total of 380 CVID patients on stable IgG replacement from two prospective cohorts were analysed. An \u2018efficiency\u2019 index was defined as the ratio of serum IgG trough level minus IgG residual to the average weekly dose of IgG infusion. A reduced efficiency of IgG was associated independently with the i.v. route (P\u2009&amp;lt;\u20090\u00b7001) and with the presence of at least one CVID disease-related phenotype (lymphoproliferation, autoimmune cytopenia or enteropathy) (P\u2009&amp;lt;\u20090\u00b7001). High IgG efficiency was noted in patients homozygotes for the variable number tandem repeat (VNTR) 3\/3 polymorphism of the neonatal Fc receptor gene [IgG Fc fragment receptor transporter alpha chain (FCGRT)] promoter, and this was particularly significant in patients treated with IVIG (P\u2009&amp;lt;\u20090.01). In a multivariate analysis, FCGRT VNTR 3\/3 genotype (P\u2009=\u20090\u00b7008) and high serum albumin (P\u2009&amp;lt;\u20090\u00b7001) were associated independently with increased efficiency of i.v. Ig.<\/jats:p>","DOI":"10.1111\/cei.12002","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T04:46:19Z","timestamp":1350276379000},"page":"186-194","source":"Crossref","is-referenced-by-count":70,"title":["Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor"],"prefix":"10.1093","volume":"171","author":[{"given":"V","family":"Gouilleux-Gruart","sequence":"first","affiliation":[{"name":"CNRS UMR 7292, Universit\u00e9 Fran\u00e7ois Rabelais, CHRU de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Chapel","sequence":"additional","affiliation":[{"name":"Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Chevret","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, UMR-717, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lucas","sequence":"additional","affiliation":[{"name":"Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Malphettes","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA3963 and CEREDIH, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Fieschi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA3963 and CEREDIH, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Patel","sequence":"additional","affiliation":[{"name":"Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Boutboul","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA3963 and CEREDIH, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M-N","family":"Marson","sequence":"additional","affiliation":[{"name":"CNRS UMR 7292, Universit\u00e9 Fran\u00e7ois Rabelais, CHRU de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA3963 and CEREDIH, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of California, Los Angeles, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Watier","sequence":"additional","affiliation":[{"name":"CNRS UMR 7292, Universit\u00e9 Fran\u00e7ois Rabelais, CHRU de Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Oksenhendler","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, H\u00f4pital Saint-Louis, AP-HP and Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, EA3963 and CEREDIH, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"DEFI study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"2021122009520089800_cei12002-bib-0001","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies. 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