{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:27:18Z","timestamp":1791973638555,"version":"4.4.0"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The causative organism of plague is the bacterium Yersinia pestis. Advances in understanding the complex pathogenesis of plague infection have led to the identification of the F1- and V-antigens as key components of a next-generation vaccine for plague, which have the potential to be effective against all forms of the disease. Here we review the roles of F1- and V-antigens in the context of the range of virulence mechanisms deployed by Y.\u2009pestis, in order to develop a greater understanding of the protective immune responses required to protect against plague.<\/jats:p>","DOI":"10.1111\/cei.12044","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T09:52:29Z","timestamp":1354873949000},"page":"1-8","source":"Crossref","is-referenced-by-count":48,"title":["Protecting against plague: towards a next-generation vaccine"],"prefix":"10.1093","volume":"172","author":[{"given":"E D","family":"Williamson","sequence":"first","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Salisbury, Wilts, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P C F","family":"Oyston","sequence":"additional","affiliation":[{"name":"Biomedical Sciences Department, Defence Science and Technology Laboratory, Salisbury, Wilts, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,11]]},"reference":[{"key":"2021122009533917500_cei12044-bib-0001","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.10.1.35","article-title":"Yersinia pestis \u2013 etiologic agent of plague","volume":"10","author":"Perry","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"2021122009533917500_cei12044-bib-0002","first-page":"138","article-title":"Plague. 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