{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T10:40:05Z","timestamp":1714732805852},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Lupus Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The lupus susceptibility interval Sle3\/5 confers responsiveness to prolactin in C57BL\/6 (B6) mice and hyperprolactinaemia induces a lupus-like phenotype in B6.Sel3\/5 mice. In this study, the immunostimulatory effects of prolactin in B6 mice containing the Sle3 portion of the Sel3\/5 interval (B6.Sle3 mice) were dissected. Because of the Sle3 interval's involvement in activation of myeloid cells, the effect of dendritic cells (DCs) from prolactin-treated B6.Sle3 mice on the phenotype of B6 mice was also evaluated. B cells from prolactin-treated B6 and B6.Sle3 mice and from B6 recipients of prolactin-modulated DCs from B6.Sle3 mice were tested for DNA-reactivity and resistance to B cell receptor (BCR)-mediated apoptosis. The expression of co-stimulatory molecules on lymphocytes and myeloid cells was also evaluated. In prolactin-treated B6.Sle3 mice, transitional type 2 B cells increased while type 1 B cells decreased as a consequence of prolactin-induced resistance to BCR-mediated apoptosis leading to the survival of DNA-reactive B cells. Follicular B cells from prolactin-treated mice expressed increased levels of CD40, B7\u00b72 and IAb, and DCs and monocytes had higher levels of CD44 and B7\u00b72 than placebo-treated mice. Adoptive transfer of DCs from prolactin-treated B6.Sle3 mice to B6 recipients demonstrated the intrinsic ability of prolactin-modulated DCs to induce a development of lupus-like characteristics in B6 mice. Based on these results, prolactin accelerates the breakdown of immune tolerance in B6.Sle3 mice by promoting the survival, maturation and activation of autoreactive B cells, DCs and macrophages.<\/jats:p>","DOI":"10.1111\/cei.12050","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T12:20:18Z","timestamp":1355487618000},"page":"311-320","source":"Crossref","is-referenced-by-count":10,"title":["Prolactin rescues and primes autoreactive B cells directly and indirectly through dendritic cells in B6.<i>Sle3<\/i>mice"],"prefix":"10.1093","volume":"172","author":[{"given":"J","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Center for Clinical and Translational Science, The Rockefeller University NY, NY, USA"},{"name":"Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Arthrtis Clinic, Montefiore Hospital, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Peeva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"2021122009545486400_cei12050-bib-0001","first-page":"253","article-title":"Prolactin and systemic lupus erythematosus","volume":"147","author":"McMurray","year":"1996","journal-title":"Ann Med Interne (Paris)"},{"key":"2021122009545486400_cei12050-bib-0002","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/096120339600500107","article-title":"Prolactin levels and antinuclear antibody profiles in women tested for connective tissue disease","volume":"5","author":"Allen","year":"1996","journal-title":"Lupus"},{"key":"2021122009545486400_cei12050-bib-0003","first-page":"476","article-title":"Elevated serum prolactin or elevated prolactin\/cortisol ratios are associated with autoimmune processes in systemic lupus erythematosus and other connective tissue diseases","volume":"23","author":"Neidhart","year":"1996","journal-title":"Br J Rheumatol"},{"key":"2021122009545486400_cei12050-bib-0004","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1191\/096120398678920307","article-title":"Clinical significance of serum and urine prolactin levels in lupus glomerulonephritis","volume":"7","author":"Miranda","year":"1998","journal-title":"Lupus"},{"key":"2021122009545486400_cei12050-bib-0005","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12016-011-8256-0","article-title":"Prolactin and autoimmunity: hyperprolactinemia correlates with serositis and anemia in SLE patients","volume":"42","author":"Orbach","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"2021122009545486400_cei12050-bib-0006","doi-asserted-by":"crossref","first-page":"A465","DOI":"10.1016\/j.autrev.2011.11.009","article-title":"Prolactin and autoimmunity","volume":"11","author":"Shelly","year":"2012","journal-title":"Autoimmun Rev"},{"key":"2021122009545486400_cei12050-bib-0007","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2211-5","article-title":"Correlation of serum prolactin levels and disease activity in systematic lupus erythematosus","author":"Karimifar","year":"2011","journal-title":"Rheumatol Int"},{"key":"2021122009545486400_cei12050-bib-0008","first-page":"55","article-title":"Association between prolactin and disease activity in systemic lupus erythematosus. 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