{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:04:38Z","timestamp":1779915878114,"version":"3.53.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["R01 AR050812"],"award-info":[{"award-number":["R01 AR050812"]}]},{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["2005-0048480"],"award-info":[{"award-number":["2005-0048480"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nuclear factor (NF)-\u03baB is a transcription factor implicated in the pathogenesis of autoimmune disorders such as rheumatoid arthritis (RA). Here we have examined the effect of intra-articular administration of the IKK inhibitor, NEMO-binding domain peptide (NBD), on the severity of collagen-induced arthritis (CIA). NBD peptides were injected intra-articularly into the knee joints of DBA\/1J mice after the onset of disease. Collagen-injected mice given a scrambled peptide served as controls. Arthritis severity was determined by visual examination of paws. Intra-articular NBD injection reduced the arthritis score and ameliorated morphological signs of bone destruction compared to the controls. Serum levels of type-II collagen-specific immunoglobulin (Ig)G2a antibodies were lower in NBD-treated mice versus the control mice, whereas the levels of type-II collagen-specific IgG1 antibodies were increased by NBD treatment. NBD treatment diminished the proinflammatory cytokines interleukin (IL)-17 and interferon (IFN)-\u03b3 in serum, but increased the regulatory cytokine IL-10. NBD-treated CIA mice exhibited significantly higher percentages and numbers of forkhead box protein 3 (FoxP3+)CD4+CD25+ regulatory T cells than controls. Immunofluorescence analysis of NBD-treated mice revealed that FoxP3 and Ym1, a marker of alternatively activated macrophages, were juxtaposed to each other within draining inguinal lymph nodes. Intra-articular administration of NBD peptide is effective as an experimental therapy in a murine model of RA. Nevertheless, the intra-articular treatment modality is still associated with systemic effects on the immune system.<\/jats:p>","DOI":"10.1111\/cei.12054","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T11:18:37Z","timestamp":1358507917000},"page":"217-227","source":"Crossref","is-referenced-by-count":28,"title":["Intra-articular nuclear factor-\u03baB blockade ameliorates collagen-induced arthritis in mice by eliciting regulatory T cells and macrophages"],"prefix":"10.1093","volume":"172","author":[{"given":"S-Y","family":"Min","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"},{"name":"Rheumatism Research Center, Catholic Research Institutes of Medical Science, The Catholic University of Korea College of Medicine, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Khobahy","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-R","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"},{"name":"Department of Internal Medicine, Rheumatism Center, Inha University School of Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Taneja","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumatology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bashmakov","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Nukala","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Orme","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sajitharan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-Y","family":"Kim","sequence":"additional","affiliation":[{"name":"Rheumatism Research Center, Catholic Research Institutes of Medical Science, The Catholic University of Korea College of Medicine, Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mohan","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"2021122009550585100_cei12054-bib-0001","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-60761-058-8_11","article-title":"Collagen-induced arthritis in mice","volume":"602","author":"Bevaart","year":"2010","journal-title":"Methods Mol 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