{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:02:31Z","timestamp":1787770951832,"version":"build-2784847793"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["RO1 GM66839-07"],"award-info":[{"award-number":["RO1 GM66839-07"]}]},{"name":"NIH","award":["5R01AI036302-12"],"award-info":[{"award-number":["5R01AI036302-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>RSV lower respiratory tract infections (LRTI) are among the most common diseases necessitating hospital admission in children. In addition to causing acute respiratory failure, RSV infections are associated with sequelae such as secondary bacterial infections and reactive airway disease. One characteristic host response observed in severe RSV-induced LRTI and\/or subsequent development of asthma is increased expression of interleukin (IL)-10. However, contradictory results have been reported regarding whether IL-10 inhibits asthmatic responses or intensifies the disease. We aimed to reconcile these discordant observations by elucidating the role of IL-10 in regulating the host response to RSV LRTI. In this study, we used a lung-specific, inducible IL-10 over-expression (OE) transgenic mouse model to address this question. Our results showed that the presence of IL-10 at the time of RSV infection not only attenuated acute inflammatory process (i.e. 24\u2009h post-infection), but also late inflammatory changes [characterized by T helper type 2 (Th2) cytokine and chemokine expression]. While this result appears contradictory to some clinical observations where elevated IL-10 levels are observed in asthmatic patients, we also found that delaying IL-10 OE until the late immune response to RSV infection, additive effects rather than inhibitory effects were observed. Importantly, in non-infected, IL-10 OE mice, IL-10 OE alone induced up-regulation of Th2 cytokine (IL-13 and IL-5) and Th2-related chemokine [monocyte chemoattractant protein 1 (MCP-1), chemokine (C-C motif) ligand 3 (CCL3) and regulated upon activation normal T cell expressed and secreted (RANTES)] expression. We identified a subset of CD11b+CD11c+CD49b+F4\/80\u2013Gr-1\u2013 myeloid cells as a prinicipal source of IL-10-induced IL-13 production. Therefore, the augmented pathological responses observed in our \u2018delayed\u2019 IL-10 over-expression model could be attributed to IL-10 OE alone. Taken together, our study indicated dual roles of IL-10 on RSV-induced lung inflammation which appear to depend upon the timing of when elevated IL-10 is expressed in the lung.<\/jats:p>","DOI":"10.1111\/cei.12059","type":"journal-article","created":{"date-parts":[[2012,12,26]],"date-time":"2012-12-26T23:06:27Z","timestamp":1356563187000},"page":"263-279","source":"Crossref","is-referenced-by-count":47,"title":["Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation"],"prefix":"10.1093","volume":"172","author":[{"given":"L","family":"Sun","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T T","family":"Cornell","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"LeVine","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Berlin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Hinkovska-Galcheva","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Fleszar","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N W","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P","family":"Shanley","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, C.S Mott Children's Hospital and the Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"2021122009552075600_cei12059-bib-0001","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1136\/thx.52.4.380","article-title":"Mechanisms of virus induced exacerbations of asthma","volume":"52","author":"Corne","year":"1997","journal-title":"Thorax"},{"key":"2021122009552075600_cei12059-bib-0002","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/(SICI)1099-0496(199709)15+<9::AID-PPUL3>3.0.CO;2-C","article-title":"Definition of pediatric asthma and associated risk factors","volume":"15","author":"Martinez","year":"1997","journal-title":"Pediatr Pulmonol Suppl"},{"key":"2021122009552075600_cei12059-bib-0003","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1172\/JCI119516","article-title":"Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen","volume":"100","author":"Schwarze","year":"1997","journal-title":"J Clin Invest"},{"key":"2021122009552075600_cei12059-bib-0004","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1378\/chest.112.3.591","article-title":"The incidence of respiratory tract infection in adults requiring hospitalization for asthma","volume":"112","author":"Teichtahl","year":"1997","journal-title":"Chest"},{"key":"2021122009552075600_cei12059-bib-0005","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1164\/ajrccm.160.5.8","article-title":"Childhood viral infection and the pathogenesis of asthma and chronic obstructive lung disease","volume":"160","author":"Hogg","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122009552075600_cei12059-bib-0006","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/physrev.00020.2001","article-title":"Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial\u2013viral\u2013allergic paradigm","volume":"82","author":"Holtzman","year":"2002","journal-title":"Physiol Rev"},{"key":"2021122009552075600_cei12059-bib-0007","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1128\/JVI.74.22.10287-10292.2000","article-title":"Efficacy and safety studies of a recombinant chimeric respiratory syncytial virus FG glycoprotein vaccine in cotton rats","volume":"74","author":"Prince","year":"2000","journal-title":"J Virol"},{"key":"2021122009552075600_cei12059-bib-0008","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1128\/jvi.68.8.5321-5325.1994","article-title":"Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB\/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10","volume":"68","author":"Connors","year":"1994","journal-title":"J Virol"},{"key":"2021122009552075600_cei12059-bib-0009","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.4049\/jimmunol.158.7.3311","article-title":"IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi","volume":"158","author":"Hunter","year":"1997","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0010","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","article-title":"Treatment of murine colitis by Lactococcus lactis secreting interleukin-10","volume":"289","author":"Steidler","year":"2000","journal-title":"Science"},{"key":"2021122009552075600_cei12059-bib-0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2332\/allergolint.O-06-454","article-title":"IL-10 and RANTES are elevated in nasopharyngeal secretions of children with respiratory syncytial virus infection","volume":"56","author":"Murai","year":"2007","journal-title":"Allergol Int"},{"key":"2021122009552075600_cei12059-bib-0012","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1164\/ajrccm.161.5.9904078","article-title":"Monocyte IL-10 production during respiratory syncytial virus bronchiolitis is associated with recurrent wheezing in a one-year follow-up study","volume":"161","author":"Bont","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122009552075600_cei12059-bib-0013","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1465-9921-12-121","article-title":"Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze","volume":"12","author":"Schuurhof","year":"2011","journal-title":"Respir Res"},{"key":"2021122009552075600_cei12059-bib-0014","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1081-1206(10)61307-5","article-title":"Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis","volume":"94","author":"Chung","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2021122009552075600_cei12059-bib-0015","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1183\/09031936.99.14230999","article-title":"Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers","volume":"14","author":"Takanashi","year":"1999","journal-title":"Eur Respir J"},{"key":"2021122009552075600_cei12059-bib-0016","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1086\/425017","article-title":"Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma","volume":"190","author":"Araujo","year":"2004","journal-title":"J Infect Dis"},{"key":"2021122009552075600_cei12059-bib-0017","doi-asserted-by":"crossref","first-page":"L251","DOI":"10.1152\/ajplung.00122.2004","article-title":"Immunoregulatory effects of regulated, lung-targeted expression of IL-10 in vivo","volume":"288","author":"Spight","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2021122009552075600_cei12059-bib-0018","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.166.5.3542","article-title":"IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent","volume":"166","author":"Tekkanat","year":"2001","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0019","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/eji.200838155","article-title":"CXCL10\/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy","volume":"38","author":"Lindell","year":"2008","journal-title":"Eur J Immunol"},{"key":"2021122009552075600_cei12059-bib-0020","doi-asserted-by":"crossref","first-page":"e1720","DOI":"10.1371\/journal.pone.0001720","article-title":"The balance between plasmacytoid DC versus conventional DC determines pulmonary immunity to virus infections","volume":"3","author":"Smit","year":"2008","journal-title":"PLoS One"},{"key":"2021122009552075600_cei12059-bib-0021","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1084\/jem.20070661","article-title":"Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines","volume":"204","author":"Schaller","year":"2007","journal-title":"J Exp Med"},{"key":"2021122009552075600_cei12059-bib-0022","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4049\/jimmunol.162.1.392","article-title":"IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense","volume":"162","author":"Steinhauser","year":"1999","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0023","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ajpath.2011.03.003","article-title":"IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease","volume":"179","author":"Mukherjee","year":"2011","journal-title":"Am J Pathol"},{"key":"2021122009552075600_cei12059-bib-0024","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.4049\/jimmunol.176.3.1937","article-title":"Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infection","volume":"176","author":"Rudd","year":"2006","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0025","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1002\/1521-4141(200211)32:11<3276::AID-IMMU3276>3.0.CO;2-5","article-title":"RANTES (CCL5) production during primary respiratory syncytial virus infection exacerbates airway disease","volume":"32","author":"Tekkanat","year":"2002","journal-title":"Eur J Immunol"},{"key":"2021122009552075600_cei12059-bib-0026","doi-asserted-by":"crossref","first-page":"4398","DOI":"10.4049\/jimmunol.158.9.4398","article-title":"Differential recruitment of leukocyte populations and alteration of airway hyperreactivity by C-C family chemokines in allergic airway inflammation","volume":"158","author":"Lukacs","year":"1997","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0027","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2353\/ajpath.2008.070537","article-title":"A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation","volume":"172","author":"Schaller","year":"2008","journal-title":"Am J Pathol"},{"key":"2021122009552075600_cei12059-bib-0028","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.coi.2008.03.011","article-title":"Initiation and maintenance of Th2 cell identity","volume":"20","author":"Nakayama","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"2021122009552075600_cei12059-bib-0029","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.4049\/jimmunol.166.5.3248","article-title":"Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40\u2013CD40 ligand interactions","volume":"166","author":"Bishop","year":"2001","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0030","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.4049\/jimmunol.0901666","article-title":"Pulmonary IL-17E (IL-25) production and IL-17RB+ myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease","volume":"183","author":"Dolgachev","year":"2009","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0031","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"Fallon","year":"2006","journal-title":"J Exp Med"},{"key":"2021122009552075600_cei12059-bib-0032","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nm1770","article-title":"Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease","volume":"14","author":"Kim","year":"2008","journal-title":"Nat Med"},{"key":"2021122009552075600_cei12059-bib-0033","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cyto.a.20064","article-title":"Accurate and simple discrimination of mouse pulmonary dendritic cell and macrophage populations by flow cytometry: methodology and new insights","volume":"61","author":"Vermaelen","year":"2004","journal-title":"Cytometry A"},{"key":"2021122009552075600_cei12059-bib-0034","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4049\/jimmunol.167.3.1141","article-title":"Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)","volume":"167","author":"Arase","year":"2001","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0035","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.4049\/jimmunol.151.5.2399","article-title":"Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family","volume":"151","author":"Fleming","year":"1993","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0036","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/382958","article-title":"Respiratory syncytial virus-induced chemokine production: linking viral replication to chemokine production in vitro and in vivo","volume":"189","author":"Miller","year":"2004","journal-title":"J Infect Dis"},{"key":"2021122009552075600_cei12059-bib-0037","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1084\/jem.183.1.195","article-title":"Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model","volume":"183","author":"Foster","year":"1996","journal-title":"J Exp Med"},{"key":"2021122009552075600_cei12059-bib-0038","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/(SICI)1098-1128(199609)16:5<407::AID-MED2>3.0.CO;2-Z","article-title":"Cellular and molecular mechanisms involved in the regulation of eosinophil trafficking in vivo","volume":"16","author":"Hogan","year":"1996","journal-title":"Med Res Rev"},{"key":"2021122009552075600_cei12059-bib-0039","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/eji.200323930","article-title":"Respiratory syncytial virus-induced CCL5\/RANTES contributes to exacerbation of allergic airway inflammation","volume":"33","author":"John","year":"2003","journal-title":"Eur J Immunol"},{"key":"2021122009552075600_cei12059-bib-0040","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/35100503","article-title":"Role of chemokines in the pathogenesis of asthma","volume":"1","author":"Lukacs","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"2021122009552075600_cei12059-bib-0041","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1128\/JVI.78.5.2232-2241.2004","article-title":"IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection","volume":"78","author":"Haeberle","year":"2004","journal-title":"J Virol"},{"key":"2021122009552075600_cei12059-bib-0042","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000158871","article-title":"Inhibition of CD8+ T lymphocytes attenuates respiratory syncytial virus-enhanced allergic inflammation","volume":"77","author":"Jiang","year":"2009","journal-title":"Respiration"},{"key":"2021122009552075600_cei12059-bib-0043","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.2353\/ajpath.2007.070578","article-title":"Respiratory virus-induced regulation of asthma-like responses in mice depends upon CD8 T cells and interferon-gamma production","volume":"171","author":"Smit","year":"2007","journal-title":"Am J Pathol"},{"key":"2021122009552075600_cei12059-bib-0044","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.immuni.2009.08.007","article-title":"Regulatory T cells in asthma","volume":"31","author":"Lloyd","year":"2009","journal-title":"Immunity"},{"key":"2021122009552075600_cei12059-bib-0045","doi-asserted-by":"crossref","first-page":"e1002173","DOI":"10.1371\/journal.ppat.1002173","article-title":"Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus","volume":"7","author":"Sun","year":"2011","journal-title":"PLoS Pathog"},{"key":"2021122009552075600_cei12059-bib-0046","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1172\/JCI117966","article-title":"Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice","volume":"95","author":"Zuany-Amorim","year":"1995","journal-title":"J Clin Invest"},{"key":"2021122009552075600_cei12059-bib-0047","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.4049\/jimmunol.174.11.6955","article-title":"In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation","volume":"174","author":"Nakagome","year":"2005","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0048","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.4049\/jimmunol.174.7.4356","article-title":"Respiratory syncytial virus (RSV) infection induces cyclooxygenase 2: a potential target for RSV therapy","volume":"174","author":"Richardson","year":"2005","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0049","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nm.2735","article-title":"Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology","volume":"18","author":"Petersen","year":"2012","journal-title":"Nat Med"},{"key":"2021122009552075600_cei12059-bib-0050","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.4049\/jimmunol.167.2.1060","article-title":"Respiratory syncytial virus predisposes mice to augmented allergic airway responses via IL-13-mediated mechanisms","volume":"167","author":"Lukacs","year":"2001","journal-title":"J Immunol"},{"key":"2021122009552075600_cei12059-bib-0051","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jaci.2003.08.046","article-title":"Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen","volume":"112","author":"Park","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2021122009552075600_cei12059-bib-0052","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI741","article-title":"Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma","volume":"101","author":"Doucet","year":"1998","journal-title":"J Clin Invest"},{"key":"2021122009552075600_cei12059-bib-0053","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1189\/jlb.72.6.1198","article-title":"Interleukin-10 differently regulates monocyte chemoattractant protein-1 gene expression depending on the environment in a human monoblastic cell line, UG3","volume":"72","author":"Ikeda","year":"2002","journal-title":"J Leukoc Biol"},{"key":"2021122009552075600_cei12059-bib-0054","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2249.2006.03085.x","article-title":"Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1\/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1\/2 signalling pathways","volume":"145","author":"Ip","year":"2006","journal-title":"Clin Exp Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/172\/2\/263\/41788445\/cei12059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/172\/2\/263\/41788445\/cei12059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T01:30:33Z","timestamp":1687915833000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/172\/2\/263\/6422740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":54,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,4,10]]},"published-print":{"date-parts":[[2013,4,10]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12059","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,5]]},"published":{"date-parts":[[2013,4,10]]}}}