{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:49:08Z","timestamp":1774640948393,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T00:00:00Z","timestamp":1366243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30901438"],"award-info":[{"award-number":["30901438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Natural Science Foundation of Liaoning Province, China","award":["201102271"],"award-info":[{"award-number":["201102271"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,18]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into the following experimental groups: control group, SAP group and EP-treated group. The tissue specimens were harvested for morphological studies, Streptavidin\u2013peroxidase immunohistochemistry examination. Pancreatic or lung tissue oedema was evaluated by tissue water content. Serum amylase and lung tissue malondialdehyde (MDA) and myeloperoxidase (MPO) were measured. Meanwhile, the nuclear factor-\u03baB (NF-\u03baB) activation, tumour necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2) levels and HMGB1 protein expression levels in the lung were studied. In the present study, we demonstrated that treatment with EP after SAP was associated with a reduction in the severity of SAP and lung injury. Treatment with EP significantly decreased the expression of TNF-\u03b1, IL-1\u03b2, HMGB1 and ameliorated MDA concentration, MPO activity in the lung in SAP rats. Compared to SAP group, administration of EP prevented pancreatitis-induced increases in nuclear translocation of NF-\u03baB in the lung. Similarly, treatment with EP significantly decreased the accumulation of neutrophils and markedly reduced the enhanced lung permeability. In conclusion, these results demonstrate that EP might play a therapeutic role in pulmonary inflammation in this SAP model.<\/jats:p>","DOI":"10.1111\/cei.12062","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T19:29:33Z","timestamp":1357759773000},"page":"417-426","source":"Crossref","is-referenced-by-count":41,"title":["Ethyl pyruvate significantly inhibits tumour necrosis factor-\u03b1, interleukin-1\u03b2 and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury"],"prefix":"10.1093","volume":"172","author":[{"given":"Z-G","family":"Luan","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, The First Hospital, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ward of Cadre, The First Hospital, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-H","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The First Hospital, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-C","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The First Hospital, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R-X","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First Hospital, Shenyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,18]]},"reference":[{"key":"2021122009535424500_cei12062-bib-0001","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000085266","article-title":"Severe acute pancreatitis: case-oriented discussion of interdisciplinary management","volume":"5","author":"Renzulli","year":"2005","journal-title":"Pancreatology"},{"key":"2021122009535424500_cei12062-bib-0002","doi-asserted-by":"crossref","first-page":"L1137","DOI":"10.1152\/ajplung.2000.279.6.L1137","article-title":"Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury","volume":"279","author":"Abraham","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2021122009535424500_cei12062-bib-0003","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/SHK.0b013e3181f7d742","article-title":"Liver X receptor \u03b1 activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor \u03baB pathway","volume":"35","author":"Solan","year":"2011","journal-title":"Shock"},{"key":"2021122009535424500_cei12062-bib-0004","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jamcollsurg.2009.05.002","article-title":"Early cytokine production risk stratifies trauma patients for multiple organ failure","volume":"209","author":"Jastrow","year":"2009","journal-title":"J Am Coll Surg"},{"key":"2021122009535424500_cei12062-bib-0005","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/path.2666","article-title":"Selective blockade of endothelial NF-kappaB pathway differentially affects systemic inflammation and multiple organ dysfunction and injury in septic mice","volume":"220","author":"Xu","year":"2010","journal-title":"J Pathol"},{"key":"2021122009535424500_cei12062-bib-0006","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.molmed.2004.12.007","article-title":"The \u2018cytokine profile\u2019: a code for sepsis","volume":"11","author":"Ulloa","year":"2005","journal-title":"Trends Mol Med"},{"key":"2021122009535424500_cei12062-bib-0007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1097\/01.shk.0000225404.51320.82","article-title":"HMGB1 signals through Toll-like receptor (TLR) 4 and TLR2","volume":"26","author":"Yu","year":"2006","journal-title":"Shock"},{"key":"2021122009535424500_cei12062-bib-0008","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ejcb.2011.11.004","article-title":"Models and mechanisms of acute lung injury caused by direct insults","volume":"91","author":"Reiss","year":"2012","journal-title":"Eur J Cell Biol"},{"key":"2021122009535424500_cei12062-bib-0009","doi-asserted-by":"crossref","first-page":"L958","DOI":"10.1152\/ajplung.00359.2004","article-title":"HMGB1 contributes to the development of acute lung injury after hemorrhage","volume":"288","author":"Kim","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2021122009535424500_cei12062-bib-0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"Scaffidi","year":"2002","journal-title":"Nature"},{"key":"2021122009535424500_cei12062-bib-0011","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.192.4.565","article-title":"High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes","volume":"192","author":"Andersson","year":"2000","journal-title":"J Exp Med"},{"key":"2021122009535424500_cei12062-bib-0012","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1152\/ajpregu.00412.2003","article-title":"Hemorrhage-induced acute lung injury is TLR-4 dependent","volume":"287","author":"Barsness","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2021122009535424500_cei12062-bib-0013","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/SHK.0b013e31824ddc81","article-title":"Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis","volume":"37","author":"Xie","year":"2012","journal-title":"Shock"},{"key":"2021122009535424500_cei12062-bib-0014","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-3083.2008.02194.x","article-title":"Protective effect of antagonist of high-mobility group box 1 on lipopolysaccharide-induced acute lung injury in mice","volume":"69","author":"Gong","year":"2009","journal-title":"Scand J Immunol"},{"key":"2021122009535424500_cei12062-bib-0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"2021122009535424500_cei12062-bib-0016","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0039-6060(99)70182-0","article-title":"Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes","volume":"126","author":"Wang","year":"1999","journal-title":"Surgery"},{"key":"2021122009535424500_cei12062-bib-0017","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/MPA.0b013e3181bab5c5","article-title":"Role of high-mobility group box 1 protein in the pathogenesis of intestinal barrier injury in rats with severe acute pancreatitis","volume":"39","author":"Luan","year":"2010","journal-title":"Pancreas"},{"key":"2021122009535424500_cei12062-bib-0018","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.imbio.2009.11.001","article-title":"HMGB1 activates nuclear factor-\u03baB signaling by RAGE and increases the production of TNF-\u03b1 in human umbilical vein endothelial cells","volume":"215","author":"Luan","year":"2010","journal-title":"Immunobiology"},{"key":"2021122009535424500_cei12062-bib-0019","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/MPA.0b013e31823cd3ef","article-title":"Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis","volume":"41","author":"Luan","year":"2012","journal-title":"Pancreas"},{"key":"2021122009535424500_cei12062-bib-0020","doi-asserted-by":"crossref","first-page":"12351","DOI":"10.1073\/pnas.192222999","article-title":"Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation","volume":"99","author":"Ulloa","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122009535424500_cei12062-bib-0021","doi-asserted-by":"crossref","first-page":"G212","DOI":"10.1152\/ajpgi.00022.2002","article-title":"Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock","volume":"283","author":"Yang","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021122009535424500_cei12062-bib-0022","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00003246-200108000-00003","article-title":"Ringer's ethyl pyruvate solution ameliorates ischemia\/reperfusion-induced intestinal mucosal injury in rats","volume":"29","author":"Sims","year":"2001","journal-title":"Crit Care Med"},{"key":"2021122009535424500_cei12062-bib-0023","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.surg.2005.04.006","article-title":"Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice","volume":"138","author":"Harada","year":"2005","journal-title":"Surgery"},{"key":"2021122009535424500_cei12062-bib-0024","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/00365528009181493","article-title":"Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis","volume":"15","author":"Aho","year":"1980","journal-title":"Scand J Gastroenterol"},{"key":"2021122009535424500_cei12062-bib-0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0039-6060(96)80299-6","article-title":"Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice","volume":"120","author":"Kusske","year":"1996","journal-title":"Surgery"},{"key":"2021122009535424500_cei12062-bib-0026","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/SHK.0b013e31815dd570","article-title":"Activated protein C attenuates leukocyte elastase-induced lung injury in mice","volume":"30","author":"Tanaka","year":"2008","journal-title":"Shock"},{"key":"2021122009535424500_cei12062-bib-0027","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1097\/01.CCM.0000148222.09869.92","article-title":"Management of the critically ill patient with severe acute pancreatitis","volume":"32","author":"Nathens","year":"2004","journal-title":"Crit Care Med"},{"key":"2021122009535424500_cei12062-bib-0028","first-page":"322","article-title":"Proceedings: arterial hypoxia in acute pancreatitis","volume":"58","author":"Imrie","year":"1976","journal-title":"Ann R Coll Surg Engl"},{"key":"2021122009535424500_cei12062-bib-0029","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00000658-197405000-00006","article-title":"Respiratory complications in acute pancreatitis","volume":"179","author":"Ranson","year":"1974","journal-title":"Ann Surg"},{"key":"2021122009535424500_cei12062-bib-0030","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.3748\/wjg.v16.i17.2094","article-title":"Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention","volume":"16","author":"Zhou","year":"2010","journal-title":"World J Gastroenterol"},{"key":"2021122009535424500_cei12062-bib-0031","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1465-9921-10-91","article-title":"Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model","volume":"10","author":"Shang","year":"2009","journal-title":"Respir Res"},{"key":"2021122009535424500_cei12062-bib-0032","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.resp.2005.07.005","article-title":"Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis","volume":"152","author":"Zhao","year":"2006","journal-title":"Respir Physiol Neurobiol"},{"key":"2021122009535424500_cei12062-bib-0033","first-page":"627","article-title":"Pathogenic role of myeloperoxidase in acute pancreatitis","volume":"8","author":"Chooklin","year":"2009","journal-title":"Hepatobiliary Pancreat Dis Int"},{"key":"2021122009535424500_cei12062-bib-0034","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.mn.7800185","article-title":"Neutrophils induce sequential focal changes in endothelial adherens junction components: role of elastase","volume":"10","author":"Ionescu","year":"2003","journal-title":"Microcirculation"},{"key":"2021122009535424500_cei12062-bib-0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jss.2008.01.004","article-title":"Zinc aspartate alleviates lung injury induced by intestinal ischemia-reperfusion in rats","volume":"151","author":"T\u00fcr\u00fct","year":"2009","journal-title":"J Surg Res"},{"key":"2021122009535424500_cei12062-bib-0036","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/path.2231","article-title":"The role of inflammatory and parenchymal cells in acute pancreatitis","volume":"213","author":"Vonlaufen","year":"2007","journal-title":"J Pathol"},{"key":"2021122009535424500_cei12062-bib-0037","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/01.shk.0000191413.94461.b0","article-title":"Acute pancreatitis: models, markers, and mediators","volume":"24","author":"Granger","year":"2005","journal-title":"Shock"},{"key":"2021122009535424500_cei12062-bib-0038","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/path.1491","article-title":"Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome","volume":"202","author":"Bhatia","year":"2004","journal-title":"J Pathol"},{"key":"2021122009535424500_cei12062-bib-0039","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2353\/ajpath.2008.070969","article-title":"Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1","volume":"172","author":"Chorny","year":"2008","journal-title":"Am J Pathol"},{"key":"2021122009535424500_cei12062-bib-0040","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1164\/rccm.200402-188OC","article-title":"Contributions of high mobility group box protein in experimental and clinical acute lung injury","volume":"170","author":"Ueno","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122009535424500_cei12062-bib-0041","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis","volume":"255","author":"Wang","year":"2004","journal-title":"J Intern Med"},{"key":"2021122009535424500_cei12062-bib-0042","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.2007.124115","article-title":"The role of NF-kappaB activation in the pathogenesis of acute pancreatitis","volume":"57","author":"Rakonczay","year":"2008","journal-title":"Gut"},{"key":"2021122009535424500_cei12062-bib-0043","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10620-007-9867-4","article-title":"Application of tissue microarrays to study the influence of dexamethasone on NF-kappaB expression of pancreas in rat with severe acute pancreatitis","volume":"53","author":"Zhang","year":"2008","journal-title":"Dig Dis Sci"},{"key":"2021122009535424500_cei12062-bib-0044","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1124\/jpet.104.079707","article-title":"Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65","volume":"312","author":"Han","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"2021122009535424500_cei12062-bib-0045","doi-asserted-by":"crossref","first-page":"G772","DOI":"10.1152\/ajpgi.00425.2005","article-title":"Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis","volume":"290","author":"Ohashi","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021122009535424500_cei12062-bib-0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(99)00421-5","article-title":"Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis","volume":"377","author":"Dabrowski","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"2021122009535424500_cei12062-bib-0047","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0039-6060(98)70080-7","article-title":"Pyruvate improves myocardial tolerance to reperfusion injury by acting as an antioxidant: a chemiluminescence study","volume":"124","author":"Crestanello","year":"1998","journal-title":"Surgery"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/172\/3\/417\/41788209\/cei12062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/172\/3\/417\/41788209\/cei12062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:19:13Z","timestamp":1641053953000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/172\/3\/417\/6421060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,18]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,4,18]]},"published-print":{"date-parts":[[2013,4,18]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12062","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,6]]},"published":{"date-parts":[[2013,4,18]]}}}