{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:28:28Z","timestamp":1781155708921,"version":"3.54.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH","award":["DE017561"],"award-info":[{"award-number":["DE017561"]}]},{"DOI":"10.13039\/100008569","name":"Oklahoma Center for the Advancement of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sj\u00f6gren's syndrome is a chronic illness manifested characteristically by immune injury to the salivary and lacrimal glands, resulting in dry mouth\/eyes. Anti-Ro [Sj\u00f6gren's syndrome antigen A (SSA)] and anti-La [Sj\u00f6gren's syndrome antigen B (SSB)] autoantibodies are found frequently in Sj\u00f6gren's subjects as well as in individuals who will go on to develop the disease. Immunization of BALB\/c mice with Ro60 peptides results in epitope spreading with anti-Ro and anti-La along with lymphocyte infiltration of salivary glands similar to human Sj\u00f6gren's. In addition, these animals have poor salivary function\/low saliva volume. In this study, we examined whether Ro-peptide immunization produces a Sj\u00f6gren's-like illness in other strains of mice. BALB\/c, DBA-2, PL\/J, SJL\/J and C57BL\/6 mice were immunized with Ro60 peptide-274. Sera from these mice were studied by immunoblot and enzyme-linked immunosorbent assay for autoantibodies. Timed salivary flow was determined after pharmacological stimulation, and salivary glands were examined pathologically. We found that SJL\/J mice had no immune response to the peptide from Ro60, while C57BL\/6 mice produced antibodies that bound the peptide but had no epitope spreading. PL\/J mice had epitope spreading to other structures of Ro60 as well as to La, but like C57BL\/6 and SJL\/J had no salivary gland lymphocytic infiltration and no decrement of salivary function. DBA-2 and BALB\/c mice had infiltration but only BALB\/c had decreased salivary function. The immunological processes leading to a Sj\u00f6gren's-like illness after Ro-peptide immunization were interrupted in a stepwise fashion in these differing mice strains. These data suggest that this is a model of preclinical disease with genetic control for epitope spreading, lymphocytic infiltration and glandular dysfunction.<\/jats:p>","DOI":"10.1111\/cei.12094","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T08:01:38Z","timestamp":1361520098000},"page":"67-75","source":"Crossref","is-referenced-by-count":19,"title":["Immunization with 60\u2009kD Ro peptide produces different stages of preclinical autoimmunity in a Sj\u00f6gren's syndrome model among multiple strains of inbred mice"],"prefix":"10.1093","volume":"173","author":[{"given":"B T","family":"Kurien","sequence":"first","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, USA"},{"name":"Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dsouza","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, USA"},{"name":"Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Igoe","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y J","family":"Lee","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Seoul National University and Seoul National University Bundang Hospital, Seoul, S. Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Maier-Moore","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, USA"},{"name":"Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gordon","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jackson","sequence":"additional","affiliation":[{"name":"Flinders University, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Scofield","sequence":"additional","affiliation":[{"name":"Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, USA"},{"name":"Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, USA"},{"name":"Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"2021122009561143800_cei12094-bib-0001","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/S0140-6736(04)16154-0","article-title":"Rapid review: autoantibodies as predictors of disease","volume":"363","author":"Scofield","year":"2004","journal-title":"Lancet"},{"key":"2021122009561143800_cei12094-bib-0002","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/08916930802031686","article-title":"Predictors of autoimmune disease: autoantibodies and beyond","volume":"41","author":"Rose","year":"2008","journal-title":"Autoimmunity"},{"key":"2021122009561143800_cei12094-bib-0003","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4161\/isl.3.4.15728","article-title":"Insulitis in human type 1 diabetes: the quest for an elusive lesion","volume":"3","author":"In't Veld","year":"2011","journal-title":"Islets"},{"key":"2021122009561143800_cei12094-bib-0004","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2010.03.018","article-title":"Prediction and pathogenesis in type 1 diabetes","volume":"32","author":"Ziegler","year":"2010","journal-title":"Immunity"},{"key":"2021122009561143800_cei12094-bib-0005","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.berh.2007.09.001","article-title":"Update on Sjogren's syndrome autoimmune epithelitis: from classification to increased neoplasias","volume":"21","author":"Tzioufas","year":"2007","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2021122009561143800_cei12094-bib-0006","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American\u2013European Consensus Group. 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