{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:52:19Z","timestamp":1790617939219,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fundaci\u00f3n \u2018Alberto J. Roemmers\u2019"},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["417\/08"],"award-info":[{"award-number":["417\/08"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"crossref","award":["427\/11"],"award-info":[{"award-number":["427\/11"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Typical haemolytic uraemic syndrome (HUS) is caused by Shiga toxin (Stx)-producing Escherichia coli infections and is characterized by thrombotic microangiopathy that leads to haemolytic anaemia, thrombocytopenia and acute renal failure. Renal or neurological sequelae are consequences of irreversible tissue damage during the acute phase. Stx toxicity and the acute inflammatory response raised by the host determine the development of HUS. At present there is no specific therapy to control Stx damage. The pathogenic role of reactive oxygen species (ROS) on endothelial injury has been largely documented. In this study, we investigated the in-vivo effects of Stx on the oxidative balance and its contribution to the development of HUS in mice. In addition, we analysed the effect of anti-oxidant agents as therapeutic tools to counteract Stx toxicity. We demonstrated that Stx induced an oxidative imbalance, evidenced by renal glutathione depletion and increased lipid membrane peroxidation. The increased ROS production by neutrophils may be one of the major sources of oxidative stress during Stx intoxication. All these parameters were ameliorated by anti-oxidants reducing platelet activation, renal damage and increasing survival. To conclude, Stx generates a pro-oxidative state that contributes to kidney failure, and exogenous anti-oxidants could be beneficial to counteract this pathogenic pathway.<\/jats:p>","DOI":"10.1111\/cei.12124","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T08:18:45Z","timestamp":1366618725000},"page":"463-472","source":"Crossref","is-referenced-by-count":44,"title":["The oxidative stress induced <i>in vivo<\/i> by Shiga toxin-2 contributes to the pathogenicity of haemolytic uraemic syndrome"],"prefix":"10.1093","volume":"173","author":[{"given":"S A","family":"Gomez","sequence":"first","affiliation":[{"name":"Servicio de Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, ANLIS \u2018Dr Carlos G. 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Repetto","sequence":"additional","affiliation":[{"name":"Laboratorio de Qu\u00edmica General, Departamento de Qu\u00edmica Anal\u00edtica y Fisico- qu\u00edmica, Facultad de Farmacia y Bioqu\u00edmica, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Mej\u00edas","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis e Inmunolog\u00eda de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX) (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G C","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis e Inmunolog\u00eda de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX) (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vanzulli","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Patolog\u00eda, Instituto de Investigaciones Oncol\u00f3gicas, Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Isturiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis e Inmunolog\u00eda de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX) (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Palermo","sequence":"additional","affiliation":[{"name":"Laboratorio de Patog\u00e9nesis e Inmunolog\u00eda de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX) (CONICET), Buenos Aires, 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