{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T16:10:32Z","timestamp":1744215032347},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Swiss National Foundation","award":["31003A_127247"],"award-info":[{"award-number":["31003A_127247"]}]},{"name":"Broad Medical Research Program","award":["IBD-0324R"],"award-info":[{"award-number":["IBD-0324R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the role of B cell lymphoma (BCL)-2-interacting mediator of cell death (Bim) for lymphocyte homeostasis in intestinal mucosa. Lymphocytes lacking Bim are refractory to apoptosis. Chronic colitis was induced in Bim-deficient mice (Bim\u2013\/\u2013) with dextran sulphate sodium (DSS). Weight loss and colonoscopic score were increased significantly in Bim\u2013\/\u2013 mice compared to wild-type mice. As Bim is induced for the killing of autoreactive cells we determined the role of Bim in the regulation of lymphocyte survival at mucosal sites. Upon chronic dextran sulphate sodium (DSS)-induced colitis, Bim\u2013\/\u2013 animals exhibited an increased infiltrate of lymphocytes into the mucosa compared to wild-type mice. The number of autoreactive T cell receptor (TCR) V\u03b28+ lymphocytes was significantly higher in Bim\u2013\/\u2013 mice compared to wild-type controls. Impaired removal of autoreactive lymphocytes in Bim\u2013\/\u2013 mice upon chronic DSS-induced colitis may therefore contribute to aggravated mucosal inflammation.<\/jats:p>","DOI":"10.1111\/cei.12137","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T08:42:41Z","timestamp":1368520961000},"page":"493-501","source":"Crossref","is-referenced-by-count":5,"title":["Impaired removal of V\u03b28+ lymphocytes aggravates colitis in mice deficient for B cell lymphoma-2-interacting mediator of cell death (Bim)"],"prefix":"10.1093","volume":"173","author":[{"given":"K","family":"Leucht","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Caj","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fried","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rogler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University Hospital of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"2021122009565821500_cei12137-bib-0001","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","article-title":"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex","volume":"3","author":"Puthalakath","year":"1999","journal-title":"Mol Cell"},{"key":"2021122009565821500_cei12137-bib-0002","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/sj.cdd.4401688","article-title":"Regulatory phosphorylation of Bim: sorting out the ERK from the JNK","volume":"12","author":"Ley","year":"2005","journal-title":"Cell Death Differ"},{"key":"2021122009565821500_cei12137-bib-0003","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4161\/cc.6.18.4728","article-title":"Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK 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