{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T01:08:27Z","timestamp":1778720907649,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,9,8]],"date-time":"2013-09-08T00:00:00Z","timestamp":1378598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fondo de Investigaci\u00f3n Sanitaria from the Spanish Government","award":["FIS PI08\/0362"],"award-info":[{"award-number":["FIS PI08\/0362"]}]},{"name":"Fondo de Investigaci\u00f3n Sanitaria from the Spanish Government","award":["FIS PI11\/0160"],"award-info":[{"award-number":["FIS PI11\/0160"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia and recurrent infections. Although the underlying cause is unknown, B cells from most CVID patients fail to differentiate to memory or plasma cells. We investigated if increased apoptosis could influence the fate of B cells. For this purpose we activated purified B lymphocytes of CVID patients with a surrogate T-dependent (anti-CD40) or T-independent [cytosine\u2013phosphate\u2013guanosine oligodeoxynucleotides (CpG-ODN) or anti-immunoglobulin (Ig)M)] stimulus with or without interleukin (IL)-21. We found that CD27+ B cells were more sensitive than CD27\u2013 B cells to spontaneous apoptosis and less sensitive to rescue from apoptosis. The addition of IL-21 down-modulated the protective effect of all the stimuli on CD27\u2013 B cells and the protective effect of CpG-ODN and anti-IgM on CD27+ B cells. In contrast, IL-21 rescued unstimulated CD27\u2013 B cells and improved the rescue of anti-CD40-stimulated CD27+ B cells. When we compared patients and controls, mainly CD27+ B cells from MB0 patients were less sensitive to rescue from apoptosis than those from MB1 patients and controls after activation, irrespective of the IL-21 effect. Increased apoptosis during an immune response could result in lower levels of immunoglobulin production in these patients.<\/jats:p>","DOI":"10.1111\/cei.12150","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T08:33:53Z","timestamp":1370507633000},"page":"97-108","source":"Crossref","is-referenced-by-count":15,"title":["CD27+ B cells from a subgroup of common variable immunodeficiency patients are less sensitive to apoptosis rescue regardless of interleukin-21 signalling"],"prefix":"10.1093","volume":"174","author":[{"given":"A","family":"Clemente","sequence":"first","affiliation":[{"name":"Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Fundaci\u00f3 d'Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (FISIB), Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Pons","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Fundaci\u00f3 d'Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (FISIB), Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Lanio","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Fundaci\u00f3 d'Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (FISIB), Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Matamoros","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Fundaci\u00f3 d'Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (FISIB), Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Immunology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Fundaci\u00f3 d'Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (FISIB), Palma de Mallorca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,9,8]]},"reference":[{"key":"2021122009595705500_cei12150-bib-0001","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"2021122009595705500_cei12150-bib-0002","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.2007.03432.x","article-title":"Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review","volume":"149","author":"Wood","year":"2007","journal-title":"Clin Exp 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