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In the current study we investigated the role of regulatory T cells (Treg) in the modulation of Th1 responses in patients with tuberculous (TB) pleurisy. Using flow cytometry we evaluated the proportion of Treg (CD4+CD25highforkhead box protein 3+), interferon (IFN)-\u03b3 and interleukin (IL)-10 expression and CD107 degranulation in peripheral blood (PB) and pleural fluid (PF) from patients with TB pleurisy. We demonstrated that the proportion of CD4+CD25+, CD4+CD25highFoxP3+ and CD8+CD25+ cells were increased in PF compared to PB samples. Mycobacterium tuberculosis stimulation increased the proportion of CD4+CD25low\/negIL-10+ in PB and CD4+ CD25low\/negIFN-\u03b3+ in PF; meanwhile, CD25high mainly expressed IL-10 in both compartments. A high proportion of CD4+CD107+ and CD8+CD107+ cells was observed in PF. Treg depletion enhanced the in-vitro M. tuberculosis-induced IFN-\u03b3 and CD4+ and CD8+ degranulation responses and decreased CD4+IL-10+ cells in PF. Our results demonstrated that in TB pleurisy Treg cells effectively inhibit not only IFN-\u03b3 expression but also the ability of CD4+ and CD8+ cells to degranulate in response to M. tuberculosis.<\/jats:p>","DOI":"10.1111\/cei.12227","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T08:59:55Z","timestamp":1382086795000},"page":"235-245","source":"Crossref","is-referenced-by-count":30,"title":["CD4+CD25highforkhead box protein 3+ regulatory T lymphocytes suppress interferon-\u03b3 and CD107 expression in CD4+ and CD8+ T cells from tuberculous pleural effusions"],"prefix":"10.1093","volume":"175","author":[{"given":"L","family":"Geffner","sequence":"first","affiliation":[{"name":"IMEX-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J I","family":"Basile","sequence":"additional","affiliation":[{"name":"IMEX-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Yokobori","sequence":"additional","affiliation":[{"name":"IMEX-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Sabio y Garc\u00eda","sequence":"additional","affiliation":[{"name":"IMEX-CONICET, Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Musella","sequence":"additional","affiliation":[{"name":"Departamento de Neumonolog\u00eda, Hospital Francisco Mu\u00f1iz, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Castagnino","sequence":"additional","affiliation":[{"name":"Departamento de Neumonolog\u00eda, Hospital Francisco Mu\u00f1iz, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M 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