{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:47:13Z","timestamp":1789634833454,"version":"4.0.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["RF2009"],"award-info":[{"award-number":["RF2009"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Italian Ministry of University and Research","doi-asserted-by":"publisher","award":["PRIN 2010"],"award-info":[{"award-number":["PRIN 2010"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["AIRC IG 11761"],"award-info":[{"award-number":["AIRC IG 11761"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,26]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Coordinated programmes of resolution are thought to initiate early after an inflammatory response begins, actively terminating leucocyte recruitment, allowing their demise via apoptosis and their clearance by phagocytosis. In this review we describe an event that could be implicated in the resolution of inflammation, i.e. the establishment of a refractory state in human neutrophils that had phagocytosed apoptotic cells. Adherent neutrophils challenged with apoptotic cells generate neutrophil extracellular traps (NETs), filaments of decondensed chromatin decorated with bioactive molecules that are involved in the capture of various microbes and in persistent sterile inflammation. In contrast, neutrophils that had previously phagocytosed apoptotic cells lose their capacity to up-regulate \u03b22 integrins and to respond to activating stimuli that induce NET generation, such as interleukin (IL)-8. A defective regulation of NET generation might contribute to the persistent inflammation and tissue injury in diseases in which the clearance of apoptotic cells is jeopardized, including systemic lupus erythematosus and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.<\/jats:p>","DOI":"10.1111\/cei.12320","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T06:56:40Z","timestamp":1394521000000},"page":"24-29","source":"Crossref","is-referenced-by-count":37,"title":["Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation"],"prefix":"10.1093","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8370-6970","authenticated-orcid":false,"given":"A A","family":"Manfredi","sequence":"first","affiliation":[{"name":"Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy"},{"name":"Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Covino","sequence":"additional","affiliation":[{"name":"Advanced Light and Electron Microscopy Bio-Imaging Center, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rovere-Querini","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy"},{"name":"Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Maugeri","sequence":"additional","affiliation":[{"name":"Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"2021122010112079400_cei12320-bib-0001","doi-asserted-by":"crossref","first-page":"a008748","DOI":"10.1101\/cshperspect.a008748","article-title":"Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion","volume":"5","author":"Hochreiter-Hufford","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2021122010112079400_cei12320-bib-0002","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H","article-title":"Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus","volume":"41","author":"Herrmann","year":"1998","journal-title":"Arthritis Rheum"},{"key":"2021122010112079400_cei12320-bib-0003","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.atherosclerosis.2008.12.042","article-title":"Anti-inflammatory action of apoptotic cells in patients with acute coronary syndromes","volume":"205","author":"Ferri","year":"2009","journal-title":"Atherosclerosis"},{"key":"2021122010112079400_cei12320-bib-0004","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/1529-0131(200008)43:8<1663::AID-ANR1>3.0.CO;2-1","article-title":"Remnants of suicidal cells fostering systemic autoaggression. 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