{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:19:02Z","timestamp":1791220742444,"version":"4.1.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>T cell and T cell-related cytokine abnormalities are involved in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study showed that the interleukin (IL)-22+CD4+T cells and IL-22 play an important role in the pathogenesis of SLE. In this study, we aimed to investigate the effects of glucocorticoids (GCs) and immunodepressant agents on IL-22 and IL-22-producing T cell subsets in SLE patients. The frequencies of peripheral blood T helper type 22 (Th22), IL-22+Th17, IL-22+Th1 and Th17 cells and the concentrations of serum IL-22, IL-17 and interferon (IFN)-\u03b3 in SLE patients receiving 4 weeks of treatment with cyclophosphamide (CYC), methylprednisolone and hydroxychloroquine (HCQ) were characterized by flow cytometry analysis and enzyme-linked immunosorbent assay (ELISA). The frequencies of Th22, IL-22+Th17 and Th17 cells and the concentrations of IL-22 and IL-17 were reduced in response to the drugs methylprednisolone, cyclophosphamide and hydroxychloroquine for 4 weeks in the majority of SLE patients. However, the percentage of Th1 cells showed no change. No differences in the levels of IL-22 and IL-22+CD4+ T cells were found between non-responders and health controls either before or after therapy. IL-22 levels were correlated positively with Th22 cells in SLE patients after treatment. These results suggest that elevated IL-22 is correlated with IL-22+CD4+T cells, especially Th22 cells, and may have a co-operative or synergetic function in the immunopathogenesis of SLE. GC, CYC and HCQ treatment may regulate the production of IL-22, possibly by correcting the IL-22+CD4+T cells polarizations in SLE, thus providing new insights into the mechanism of GC, CYC and HCQ in the treatment of SLE.<\/jats:p>","DOI":"10.1111\/cei.12330","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T06:51:39Z","timestamp":1395125499000},"page":"212-218","source":"Crossref","is-referenced-by-count":22,"title":["Immunoregulation therapy changes the frequency of interleukin (IL)-22+CD4+T cells in systemic lupus erythematosus patients"],"prefix":"10.1093","volume":"177","author":[{"given":"L","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Rheumatology, The First Hospital, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Hospital, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Hospital, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, the Second Part of First Hospital, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Hospital, Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"2021122010062882600_cei12330-bib-0001","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jaci.2007.06.039","article-title":"TH17 cells in the big picture of 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