{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:44:29Z","timestamp":1760708669793,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008392","name":"Danish Council for Independent Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Danish Colitis\u2013Crohn Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Hepatosplenic \u03b3\u03b4 T cell lymphoma (HSTCL) has been observed in patients with Crohn's disease (CD) who received anti-tumour necrosis factor (TNF)-\u03b1 agents and thiopurines, but only one case was reported in a psoriasis patient worldwide. This difference could be due to differences in either the nature of the inflammatory diseases or in the use of immunomodulators. We investigated the impact of anti-TNF-\u03b1 agents on the level and repertoire of \u03b3\u03b4 T cells in peripheral blood from psoriasis patients. Forty-five men and 10 women who were treated with anti-TNF-\u03b1 agents for psoriasis were monitored for a median 11 months for the level and clonality of \u03b3\u03b4 T cells via flow cytometry and polymerase chain reaction (PCR) analysis of T cell receptor gamma (TCR-\u03b3) gene rearrangements. Seventeen men had a repeated analysis within 48 h of the infliximab infusion to reveal a possible expansion of \u03b3\u03b4 T cells, as observed previously in CD patients. Ten psoriasis patients who were never exposed to biologicals and 20 healthy individuals served as controls. In the majority of psoriasis patients, the level and clonal pattern of \u03b3\u03b4 T cells was remarkably stable during infliximab treatment. A single male patient repeatedly experienced a significant increase in the level of \u03b3\u03b4 T cells after infliximab infusions. A monoclonal \u03b3\u03b4 T cell repertoire in a polyclonal background tended to be more frequent in anti-TNF-\u03b1-treated patients than naive patients, suggesting that anti-TNF-\u03b1 therapy may promote the clonal selection of \u03b3\u03b4 T cells in psoriasis patients.<\/jats:p>","DOI":"10.1111\/cei.12331","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T06:51:40Z","timestamp":1395125500000},"page":"142-148","source":"Crossref","is-referenced-by-count":9,"title":["Frequency and clonality of peripheral \u03b3\u03b4 T cells in psoriasis patients receiving anti-tumour necrosis factor-\u03b1 therapy"],"prefix":"10.1093","volume":"177","author":[{"given":"J","family":"Kelsen","sequence":"first","affiliation":[{"name":"Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Randers, Denmark"},{"name":"Department of Medicine, Randers Regional Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dige","sequence":"additional","affiliation":[{"name":"Gastro-Immuno Research Laboratory (GIRL), Department of Hepatology and Gastroenterology, Aarhus University Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Christensen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Aarhus University Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"D'Amore","sequence":"additional","affiliation":[{"name":"Department of Hematology, Aarhus University Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Aarhus University Hospital, Randers, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"2021122010063276500_cei12331-bib-0001","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrclinonc.2009.169","article-title":"Gamma-delta T-cell lymphomas","volume":"6","author":"Tripodo","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"2021122010063276500_cei12331-bib-0002","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1182\/blood-2008-07-166363","article-title":"Gene expression profiling of peripheral T-cell lymphoma including gammadelta T-cell lymphoma","volume":"113","author":"Miyazaki","year":"2009","journal-title":"Blood"},{"key":"2021122010063276500_cei12331-bib-0003","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1046\/j.1365-2133.1996.d01-1106.x","article-title":"Clinical and pathological heterogeneity in cutaneous gamma-delta T-cell lymphoma: a report of three cases and a review of 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