{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:31Z","timestamp":1740126451274,"version":"3.37.3"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T00:00:00Z","timestamp":1415318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown several allergic and metabolic alterations after 7 days of ovalbumin (OVA) ingestion by sensitized mice. The aim of this study was to investigate whether prolonged ingestion of antigen by sensitized mice would reverse the metabolic consequences caused by experimental food allergy. For this, allergic and metabolic parameters were analysed after prolonged ingestion of an OVA diet by OVA-sensitized mice. As shown previously, after 7 days of OVA consumption, sensitized mice showed increased serum levels of anti-OVA immunoglobulin (Ig)E and IgG1, aversion to the antigen ingestion, marked body and adipose tissue weight loss, followed by adipose tissue inflammation and decreased serum levels of adipokines, glucose and triglycerides. However, after 14 days of oral challenge, sensitized mice showed an anti-OVA IgE level similar to the mice that were only sensitized, but the specific IgG1 did not change. With this prolonged ingestion of OVA, sensitized mice were protected from OVA-induced anaphylaxis when the antigen was given systemically at a dose of 2 mg\/animal. Moreover, various parameters analysed were significantly ameliorated, including adipose tissue inflammation, body and adipose tissue loss, as well as serum levels of adipokines and triglycerides. Therefore, our data suggest that prolonged ingestion of OVA by sensitized mice results in an improvement of the metabolic consequences caused by experimental food allergy.<\/jats:p>","DOI":"10.1111\/cei.12435","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T06:27:01Z","timestamp":1407824821000},"page":"416-427","source":"Crossref","is-referenced-by-count":12,"title":["Prolonged ingestion of ovalbumin diet by sensitized mice improves the metabolic consequences induced by experimental food allergy"],"prefix":"10.1093","volume":"178","author":[{"given":"N V","family":"Batista","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Immunology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R V S","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L M","family":"Noviello","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L P A","family":"Dourado","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Morphology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Foureaux","sequence":"additional","affiliation":[{"name":"Department of Morphology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A V M","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Nursing School, Federal University of Minas Gerais, UFMG, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Cara","sequence":"additional","affiliation":[{"name":"Department of Morphology, Biological Sciences Institute, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,7]]},"reference":[{"key":"2021122010082617500_cei12435-bib-0001","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jaci.2009.08.028","article-title":"Food allergy","volume":"125","author":"Sicherer","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0002","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.jaci.2007.05.026","article-title":"The prevalence of food allergy: a meta-analysis","volume":"120","author":"Rona","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0003","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1398-9995.2007.01570.x","article-title":"Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life","volume":"63","author":"Venter","year":"2008","journal-title":"Allergy"},{"key":"2021122010082617500_cei12435-bib-0004","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2222.1992.tb02816.x","article-title":"Higher risk of infantile atopic dermatitis from maternal atopy than from paternal atopy","volume":"22","author":"Ruiz","year":"1992","journal-title":"Clin Exp Allergy"},{"key":"2021122010082617500_cei12435-bib-0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/01.all.0000011019.11362.f3","article-title":"Prevention","volume":"1","author":"Halken","year":"2001","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0006","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.0105-2896.2005.00280.x","article-title":"Oral tolerance","volume":"206","author":"Faria","year":"2005","journal-title":"Immunol Rev"},{"key":"2021122010082617500_cei12435-bib-0007","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2004.11.008","article-title":"Oral tolerance and its relation to food hypersensitivities","volume":"115","author":"Chehade","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0008","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/mnfr.201000634","article-title":"Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy","volume":"55","author":"Burggraf","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"2021122010082617500_cei12435-bib-0009","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1111\/j.1398-9995.2009.01982.x","article-title":"Successful oral tolerance induction in severe peanut allergy","volume":"64","author":"Clark","year":"2009","journal-title":"Allergy"},{"key":"2021122010082617500_cei12435-bib-0010","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2008.02.037","article-title":"Oral tolerance, food allergy, and immunotherapy: implications for future treatment","volume":"121","author":"Burks","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0011","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/ACI.0b013e3283399404","article-title":"Is oral immunotherapy the cure for food allergies?","volume":"10","author":"Nowak-Wegrzyn","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0012","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.iac.2011.02.008","article-title":"Oral desensitization for food hypersensitivity","volume":"31","author":"Land","year":"2011","journal-title":"Immunol Allergy Clin North Am"},{"key":"2021122010082617500_cei12435-bib-0013","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1590\/S0100-879X2004000600005","article-title":"A model of chronic IgE-mediated food allergy in ovalbumin-sensitized mice","volume":"37","author":"Saldanha","year":"2004","journal-title":"Braz J Med Biol Res"},{"key":"2021122010082617500_cei12435-bib-0014","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.cellimm.2011.05.008","article-title":"Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice","volume":"270","author":"Dourado","year":"2011","journal-title":"Cell Immunol"},{"key":"2021122010082617500_cei12435-bib-0015","article-title":"Prolonged antigen ingestion by sensitized mice ameliorates airway inflammation","volume":"2011","author":"Noviello Mde","year":"2011","journal-title":"ISRN Allergy"},{"key":"2021122010082617500_cei12435-bib-0016","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cellimm.2013.07.005","article-title":"Prolonged ingestion of ovalbumin diet by Ova sensitized mice suppresses mBSA-induced arthritis","volume":"284","author":"Noviello Mde","year":"2013","journal-title":"Cell Immunol"},{"key":"2021122010082617500_cei12435-bib-0017","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/jn\/123.11.1923","article-title":"Development and testing of the AIN-93 purified diets for rodents: results on growth, kidney calcification and bone mineralization in rats and mice","volume":"123","author":"Reeves","year":"1993","journal-title":"J Nutr"},{"key":"2021122010082617500_cei12435-bib-0018","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cellimm.2009.12.010","article-title":"Role of IL-4 in aversion induced by food allergy in mice","volume":"262","author":"Dourado","year":"2010","journal-title":"Cell Immunol"},{"key":"2021122010082617500_cei12435-bib-0019","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)51687-2","article-title":"Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis","volume":"239","author":"Rodbell","year":"1964","journal-title":"J Biol Chem"},{"key":"2021122010082617500_cei12435-bib-0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-5728(03)00166-8","article-title":"Neural correlates of IgE-mediated food allergy","volume":"140","author":"Basso","year":"2003","journal-title":"J Neuroimmunol"},{"key":"2021122010082617500_cei12435-bib-0021","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1399-3038.2007.00700.x","article-title":"Nutritional problems related to food allergy in childhood","volume":"19","author":"Noimark","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"2021122010082617500_cei12435-bib-0022","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaci.2006.09.016","article-title":"Egg oral immunotherapy in nonanaphylactic children with egg allergy","volume":"119","author":"Buchanan","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0023","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jaci.2008.09.030","article-title":"A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy","volume":"122","author":"Skripak","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0024","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1365-2222.2011.03699.x","article-title":"Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome","volume":"41","author":"Anagnostou","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"2021122010082617500_cei12435-bib-0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.jaci.2010.05.040","article-title":"Mechanisms of allergen-specific desensitization","volume":"126","author":"Uermosi","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0026","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1172\/JCI25575","article-title":"IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking","volume":"116","author":"Strait","year":"2006","journal-title":"J Clin Invest"},{"key":"2021122010082617500_cei12435-bib-0027","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jaci.2012.04.009","article-title":"Oral immunotherapy induces local protective mechanisms in the gastrointestinal mucosa","volume":"129","author":"Leonard","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010082617500_cei12435-bib-0028","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000179663","article-title":"Pharmacological manipulation of immune-induced food aversion in rats","volume":"16","author":"Zarzana","year":"2009","journal-title":"Neuroimmunomodulation"},{"key":"2021122010082617500_cei12435-bib-0029","first-page":"1331","article-title":"Immunological induction of flavor aversion in mice","volume":"27","author":"Cara","year":"1994","journal-title":"Braz J Med Biol Res"},{"key":"2021122010082617500_cei12435-bib-0030","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1210\/jc.2002-021687","article-title":"Interleukin-6 stimulates lipolysis and fat oxidation in humans","volume":"88","author":"van Hall","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122010082617500_cei12435-bib-0031","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021122010082617500_cei12435-bib-0032","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/jc.2007-1761","article-title":"Tumor necrosis factor-alpha modulates human in vivo lipolysis","volume":"93","author":"Plomgaard","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122010082617500_cei12435-bib-0033","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"2021122010082617500_cei12435-bib-0034","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2169\/internalmedicine.45.1733","article-title":"Regulation of body weight by leptin, with special reference to hypoxia-induced regulation","volume":"45","author":"Yingzhong","year":"2006","journal-title":"Intern Med"},{"key":"2021122010082617500_cei12435-bib-0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature11047","article-title":"Allergic host defences","volume":"484","author":"Palm","year":"2012","journal-title":"Nature"},{"key":"2021122010082617500_cei12435-bib-0036","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0083-6729(00)59010-4","article-title":"Control of food intake via leptin receptors in the hypothalamus","volume":"59","author":"Meister","year":"2000","journal-title":"Vitam Horm"},{"key":"2021122010082617500_cei12435-bib-0037","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00041433-200312000-00003","article-title":"Obesity, adiponectin and vascular inflammatory disease","volume":"14","author":"Ouchi","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"2021122010082617500_cei12435-bib-0038","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"2021122010082617500_cei12435-bib-0039","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.2337\/diabetes.51.6.1737","article-title":"Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells","volume":"51","author":"Shojima","year":"2002","journal-title":"Diabetes"},{"key":"2021122010082617500_cei12435-bib-0040","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1126\/science.1092341","article-title":"Regulation of fasted blood glucose by resistin","volume":"303","author":"Banerjee","year":"2004","journal-title":"Science"},{"key":"2021122010082617500_cei12435-bib-0041","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2337\/db05-0615","article-title":"Loss of resistin improves glucose homeostasis in leptin deficiency","volume":"55","author":"Qi","year":"2006","journal-title":"Diabetes"},{"key":"2021122010082617500_cei12435-bib-0042","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1097\/00004872-200410000-00021","article-title":"Blockade of the renin\u2013angiotensin system decreases adipocyte size with improvement in insulin sensitivity","volume":"22","author":"Furuhashi","year":"2004","journal-title":"J Hypertens"},{"key":"2021122010082617500_cei12435-bib-0043","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cellimm.2012.12.004","article-title":"Oral tolerance correlates with high levels of lymphocyte activity","volume":"280","author":"Castro-Junior","year":"2012","journal-title":"Cell Immunol"},{"key":"2021122010082617500_cei12435-bib-0044","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/stem.523","article-title":"Adipose tissue as a dedicated reservoir of functional mast cell progenitors","volume":"28","author":"Poglio","year":"2010","journal-title":"Stem Cells"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12435","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/178\/3\/416\/41789700\/cei12435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/178\/3\/416\/41789700\/cei12435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:26:53Z","timestamp":1641054413000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/178\/3\/416\/6421228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,7]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,11,7]]},"published-print":{"date-parts":[[2014,11,7]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12435","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"type":"print","value":"0009-9104"},{"type":"electronic","value":"1365-2249"}],"subject":[],"published-other":{"date-parts":[[2014,12]]},"published":{"date-parts":[[2014,11,7]]}}}