{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:10:05Z","timestamp":1788869405595,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 620 IRTG-IMM project Z3"],"award-info":[{"award-number":["SFB 620 IRTG-IMM project Z3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 620 project C7"],"award-info":[{"award-number":["SFB 620 project C7"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004431","name":"European Commission Directorate-General for Research and Innovation","doi-asserted-by":"publisher","award":["EUROPADnet HEALTH-F2\u00e2\u20ac\u201c2008-201549"],"award-info":[{"award-number":["EUROPADnet HEALTH-F2\u00e2\u20ac\u201c2008-201549"]}],"id":[{"id":"10.13039\/100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01EO1303"],"award-info":[{"award-number":["BMBF 01EO1303"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006435","name":"CEITEC","doi-asserted-by":"crossref","award":["CZ.1.05\/1.1.00\/02.0068"],"award-info":[{"award-number":["CZ.1.05\/1.1.00\/02.0068"]}],"id":[{"id":"10.13039\/501100006435","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels and genotyping single nucleotide polymorphisms (SNPs) in the FCN2 and FCN3 genes. Our results show that ficolin-2 levels in CVID patients are significantly lower (P &amp;lt; 0\u00b70001) than in controls. The lowest ficolin-2 levels are found in CVID patients with bronchiectasis (P = 0\u00b70004) and autoimmunity (P = 0\u00b704). Although serum levels of ficolin-3 were similar in CVID patients and controls, CVID patients with bronchiectasis again showed lower levels when compared to controls (P = 0\u00b70001). Analysis of single nucleotide polymorphisms in the FCN2 gene confirmed known influences on ficolin-2 serum levels, but did not support a genetic basis for the observed ficolin-2 deficiency in CVID. We found that CVID patients with bronchiectasis have very low levels of ficolin-2. The reason for the deficiency of ficolin-2 in CVID and any possible causal relationship is currently unknown. However, as bronchiectasis is a very important factor for morbidity and mortality in CVID, ficolin-2 could also serve as biomarker for monitoring disease complications such as bronchiectasis.<\/jats:p>","DOI":"10.1111\/cei.12459","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T23:29:12Z","timestamp":1411514952000},"page":"256-264","source":"Crossref","is-referenced-by-count":22,"title":["Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis"],"prefix":"10.1093","volume":"179","author":[{"given":"M-L","family":"Metzger","sequence":"first","affiliation":[{"name":"Centre for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Michelfelder","sequence":"additional","affiliation":[{"name":"Centre for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Goldacker","sequence":"additional","affiliation":[{"name":"Centre for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Melkaoui","sequence":"additional","affiliation":[{"name":"Centre for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Litzman","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, St. Anne's University Hospital, Brno, Czech Republic"},{"name":"Faculty of Medicine, Masaryk University, Brno, Czech Republic"},{"name":"Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech 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