{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:40Z","timestamp":1787014000392,"version":"build-2736575974"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Reparixin, a CXCR 1\/2 antagonist, has been shown to mitigate ischaemia\u2013reperfusion injury (IRI) in various organ systems in animals, but data in humans are scarce. The aim of this double-blinded, placebo-controlled pilot study was to evaluate the safety and efficacy of reparixin to suppress IRI and inflammation in patients undergoing on-pump coronary artery bypass grafting (CABG). Patients received either reparixin or placebo (n = 16 in each group) after induction of anaesthesia until 8 h after cardiopulmonary bypass (CPB). We compared markers of systemic and pulmonary inflammation, surrogates of myocardial IRI and clinical outcomes using Mann\u2013Whitney U- and Fisher's exact tests. Thirty- and 90-day mortality was 0% in both groups. No side effects were observed in the treatment group. Surgical revision, pleural and pericardial effusion, infection and atrial fibrillation rates were not different between groups. Reparixin significantly reduced the proportion of neutrophil granulocytes in blood at the beginning [49%, interquartile range (IQR) = 45\u201357 versus 58%, IQR = 53\u201366, P = 0\u00b7035], end (71%, IQR = 67\u201376 versus 79%, IQR = 71\u201383, P = 0\u00b7023) and 1 h after CPB (73%, IQR = 71\u201375 versus 77%, IQR = 72\u201380, P = 0\u00b7035). Reparixin patients required a lesser positive fluid balance during surgery (2575 ml, IQR = 2027\u20133080 versus 3200 ml, IQR = 2928\u20133778, P = 0\u00b7029) and during ICU stay (2603 ml, IQR = 1023\u20134288 versus 4200 ml, IQR = 2313\u20138160, P = 0\u00b7021). Numerically, more control patients required noradrenaline \u2265 0\u00b711 \u03bcg\/kg\/min (50 versus 19%, P = 0\u00b7063) and dobutamine (50 versus 25%, P = 0\u00b714). Therefore, administration of reparixin in CABG patients appears to be feasible and safe. It concurrently attenuated postoperative granulocytosis in peripheral blood.<\/jats:p>","DOI":"10.1111\/cei.12488","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T05:32:13Z","timestamp":1416202333000},"page":"131-142","source":"Crossref","is-referenced-by-count":43,"title":["A pilot study on reparixin, a CXCR1\/2 antagonist, to assess safety and efficacy in attenuating ischaemia\u2013reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery"],"prefix":"10.1093","volume":"180","author":[{"given":"P","family":"Opfermann","sequence":"first","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Derhaschnig","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Felli","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wenisch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Santer","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Hietzing Hospital, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Zuckermann","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dworschak","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Jilma","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Steinlechner","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Anesthesia and Intensive Care, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"2021122010130605900_cei12488-bib-0001","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc1388","article-title":"Cancer and the chemokine network","volume":"4","author":"Balkwill","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"2021122010130605900_cei12488-bib-0002","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0952-7915(00)00096-0","article-title":"Chemokines in tissue-specific and microenvironment-specific lymphocyte homing","volume":"12","author":"Campbell","year":"2000","journal-title":"Curr Opin Immunol"},{"key":"2021122010130605900_cei12488-bib-0003","doi-asserted-by":"crossref","first-page":"740987","DOI":"10.1155\/2012\/740987","article-title":"CXCR2 in acute lung injury","volume":"2012","author":"Konrad","year":"2012","journal-title":"Mediators Inflamm"},{"key":"2021122010130605900_cei12488-bib-0004","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2012.05.008","article-title":"The chemokine superfamily revisited","volume":"36","author":"Zlotnik","year":"2012","journal-title":"Immunity"},{"key":"2021122010130605900_cei12488-bib-0005","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1840701","article-title":"Structure and functional expression of a human interleukin-8 receptor","volume":"253","author":"Holmes","year":"1991","journal-title":"Science"},{"key":"2021122010130605900_cei12488-bib-0006","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1074\/jbc.271.1.225","article-title":"CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. 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