{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:32:31Z","timestamp":1784543551322,"version":"3.55.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["94-101-12676"],"award-info":[{"award-number":["94-101-12676"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase and Ejnar Danielsen Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY008976"],"award-info":[{"award-number":["EY008976"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY011708"],"award-info":[{"award-number":["EY011708"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK063121"],"award-info":[{"award-number":["DK063121"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY007003"],"award-info":[{"award-number":["EY007003"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bell Charitable Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression of intact forkhead box protein 3 (FoxP3) compared to FoxP3\u03942, missing exon 2. Th17 and Th10 cell differentiation has usually been studied using polyclonal stimuli, and little is known about the ability of physiologically relevant self-antigens to induce Th17 or Th10 cell differentiation in autoimmune thyroid disease. We subjected mononuclear cells from healthy donors and patients with Hashimoto's thyroiditis (HT) or Graves' disease (GD) to polyclonal stimulation, or stimulation with human thyroglobulin (TG), human thyroid peroxidase (TPO), or Esherichia coli lipopolysaccharide (LPS). TPO and LPS induced increased differentiation of naive CD4+CD45RA+CD45R0\u2013 T cells from HT patients into Th17 cells. Th10 cell proportions were decreased in HT after polyclonal stimulation, but were comparable to those of healthy donors after antigen-specific stimulation. Taken together, our data show that an increased Th17 : Th10 ratio was found in HT patients after stimulation with thyroid-specific self-antigens. We also observed an elevated baseline production of IL-6 and transforming growth factor (TGF)-\u03b21 and of mRNA encoding FoxP3\u03942 rather than intact FoxP3. This may contribute to the skewing towards Th17 cell responses in HT.<\/jats:p>","DOI":"10.1111\/cei.12557","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T06:17:17Z","timestamp":1416550637000},"page":"58-69","source":"Crossref","is-referenced-by-count":49,"title":["Altered balance between self-reactive T helper (Th)17 cells and Th10 cells and between full-length forkhead box protein 3 (FoxP3) and FoxP3 splice variants in Hashimoto's thyroiditis"],"prefix":"10.1093","volume":"180","author":[{"given":"B","family":"Kristensen","sequence":"first","affiliation":[{"name":"Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Heged\u00fcs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H O","family":"Madsen","sequence":"additional","affiliation":[{"name":"The Tissue Typing Laboratory, Department of Clinical Immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T J","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, and Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Institute for Inflammation Research, Department of Infectious Diseases and Rheumatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"2021122010131141800_cei12557-bib-0001","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/ni0901-769","article-title":"Determinants of autoimmune thyroid disease","volume":"2","author":"Weetman","year":"2001","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0002","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins","volume":"136","author":"Mosmann","year":"1986","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0003","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"2021122010131141800_cei12557-bib-0004","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol Today"},{"key":"2021122010131141800_cei12557-bib-0005","first-page":"323","article-title":"Enhanced production of gamma-interferon by thyroid-derived T cell clones from patients with Hashimoto's thyroiditis","volume":"69","author":"Del Prete","year":"1987","journal-title":"Clin Exp Immunol"},{"key":"2021122010131141800_cei12557-bib-0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08916939908994754","article-title":"Balance of Th1\/Th2 cytokines in thyroid autoantibody synthesis in vitro","volume":"30","author":"Guo","year":"1999","journal-title":"Autoimmunity"},{"key":"2021122010131141800_cei12557-bib-0007","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1046\/j.1365-2249.1996.d01-784.x","article-title":"Intrathyroidal cytokine gene expression in Hashimoto's thyroiditis","volume":"105","author":"Ajjan","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"2021122010131141800_cei12557-bib-0008","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10875-006-9000-z","article-title":"Self-reactive CD4+ T cells and B cells in the blood in health and autoimmune disease: increased frequency of thyroglobulin-reactive cells in Graves' disease","volume":"26","author":"Nielsen","year":"2006","journal-title":"J Clin Immunol"},{"key":"2021122010131141800_cei12557-bib-0009","first-page":"72","article-title":"Functional lymphocyte subset assessment of the Th1\/Th2 profile in patients with autoimmune thyroiditis by flow cytometric analysis of peripheral lymphocytes","volume":"18","author":"Colin","year":"2004","journal-title":"J Biol Regul Homeost Agents"},{"key":"2021122010131141800_cei12557-bib-0010","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin-17 producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0011","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17 cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol Rev"},{"key":"2021122010131141800_cei12557-bib-0012","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/ndt\/gfm800","article-title":"Th17 cells: a third subset of CD4+ T effector cells involved in organ-specific autoimmunity","volume":"23","author":"Kurts","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"2021122010131141800_cei12557-bib-0013","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-3083.2010.02425.x","article-title":"Differentiation imbalance of Th1\/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto's thyroiditis","volume":"72","author":"Shi","year":"2010","journal-title":"Scand J Immunol"},{"key":"2021122010131141800_cei12557-bib-0014","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1089\/thy.2008.0423","article-title":"Increases of the Th1\/Th2 cell ratio in severe Hashimoto's disease and in the proportion of Th17 cells in intractable Graves' disease","volume":"19","author":"Nanba","year":"2009","journal-title":"Thyroid"},{"key":"2021122010131141800_cei12557-bib-0015","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/jc.2009-1719","article-title":"Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis","volume":"95","author":"Figueroa-Vega","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122010131141800_cei12557-bib-0016","doi-asserted-by":"crossref","first-page":"e68446","DOI":"10.1371\/journal.pone.0068446","article-title":"A high frequency of circulating Th22 and Th17 cells in patients with new onset Graves' disease","volume":"8","author":"Peng","year":"2013","journal-title":"PLOS ONE"},{"key":"2021122010131141800_cei12557-bib-0017","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jaut.2009.03.010","article-title":"Naturally-existing CD4+CD25+Foxp3+ regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen","volume":"33","author":"Morris","year":"2009","journal-title":"J Autoimmun"},{"key":"2021122010131141800_cei12557-bib-0018","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1210\/jc.2005-2337","article-title":"Regulatory T cells in human autoimmune thyroid disease","volume":"91","author":"Marazuela","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122010131141800_cei12557-bib-0019","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-065X.2001.1820105.x","article-title":"Type 1 T regulatory cells","volume":"182","author":"Roncarolo","year":"2006","journal-title":"Immunol Rev"},{"key":"2021122010131141800_cei12557-bib-0020","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"2021122010131141800_cei12557-bib-0021","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0022","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor \u03b1-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0023","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.4049\/jimmunol.173.12.7259","article-title":"CD25\u2013 T cells generate CD25+FOXP3+regulatory T cells by peripheral expansion","volume":"173","author":"Curotto de Lafaille","year":"2004","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0024","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.193.11.1303","article-title":"Ex vivo isolation and characterization of CD4+ CD25+ T cells with regulatory properties from human blood","volume":"193","author":"Dieckmann","year":"2001","journal-title":"J Exp Med"},{"key":"2021122010131141800_cei12557-bib-0025","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.1834400100","article-title":"CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-\u03b2\u2013TGF-\u03b2 receptor interactions in type 1 diabetes","volume":"100","author":"Green","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010131141800_cei12557-bib-0026","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.4049\/jimmunol.0803646","article-title":"Regulatory T cell suppression is potentiated by Target T cells in a cell contact, IL-35- and IL-10-dependent manner","volume":"182","author":"Collison","year":"2009","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0027","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.158.1.180","article-title":"Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo","volume":"158","author":"Sundstedt","year":"1997","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0028","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.2012.0514","article-title":"Impairment of regulatory T-cell function in autoimmune thyroid disease","volume":"23","author":"Glick","year":"2013","journal-title":"Thyroid"},{"key":"2021122010131141800_cei12557-bib-0029","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2265.2009.03544.x","article-title":"Regulatory T cells in Graves' disease","volume":"71","author":"Pan","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2021122010131141800_cei12557-bib-0030","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2249.2006.03283.x","article-title":"Production of interleukin (IL)-5 and IL-10 accompanies T helper cell type 1 (Th1) cytokine responses to a major thyroid self-antigen, thyroglobulin, in health and autoimmune thyroid disease","volume":"147","author":"Nielsen","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2021122010131141800_cei12557-bib-0031","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1365-2567.2009.03183.x","article-title":"The self-antigen, thyroglobulin, induces antigen-experienced CD4+ T cells from healthy donors to proliferate and promote production of the regulatory cytokine, interleukin-10, by monocytes","volume":"129","author":"Nielsen","year":"2009","journal-title":"Immunology"},{"key":"2021122010131141800_cei12557-bib-0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2012.07.004","article-title":"B-cell exposure to self-antigen induces IL-10 producing B cells as well as IL-6 and TNF-\u03b1 producing B-cell subsets in healthy humans","volume":"145","author":"Langkj\u00e6r","year":"2012","journal-title":"Clin Immunol"},{"key":"2021122010131141800_cei12557-bib-0033","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature07021","article-title":"IL-21 and TGF-beta are required for differentiation of human T(H)17 cell","volume":"454","author":"Yang","year":"2008","journal-title":"Nature"},{"key":"2021122010131141800_cei12557-bib-0034","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ni1496","article-title":"Interleukins 1\u03b2 and 6 but not transforming growth factor-\u03b2 are essential for the differentiation of interleukin 17-producing human T helper cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0035","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/ni.1610","article-title":"The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammaT","volume":"9","author":"Manel","year":"2008","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGF-beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"2021122010131141800_cei12557-bib-0037","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"2021122010131141800_cei12557-bib-0038","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1073\/pnas.0900621106","article-title":"Human memory FOXP3 Tregs secrete IL-17 ex vivo and constitutively express the Th17 lineage-specific transcription factor RORgammaT","volume":"106","author":"Ayyoub","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010131141800_cei12557-bib-0039","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1182\/blood-2008-01-133967","article-title":"Human CD25high FOXP3+ regulatory T cells differentiate into IL-17-producing cells","volume":"112","author":"Koenen","year":"2008","journal-title":"Blood"},{"key":"2021122010131141800_cei12557-bib-0040","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1182\/blood-2008-10-183251","article-title":"IL-17-producing human peripheral regulatory T cells retain suppressive function","volume":"113","author":"Beriou","year":"2009","journal-title":"Blood"},{"key":"2021122010131141800_cei12557-bib-0041","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jaut.2008.04.017","article-title":"Role of Th1 and Th17 cells in organ-specific autoimmunity","volume":"31","author":"Dardalhon","year":"2008","journal-title":"J Autoimmun"},{"key":"2021122010131141800_cei12557-bib-0042","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/ni1539","article-title":"TGF-\u03b2 and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology","volume":"8","author":"McGreachy","year":"2007","journal-title":"Nat Immunol"},{"key":"2021122010131141800_cei12557-bib-0043","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature10957","article-title":"Pathogen-induced human TH17 cells produce IFN-\u03b3 or IL-10 and are regulated by IL-1\u03b2","volume":"484","author":"Zielinski","year":"2012","journal-title":"Nature"},{"key":"2021122010131141800_cei12557-bib-0044","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2567.2008.02837.x","article-title":"T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis","volume":"125","author":"Hedegaard","year":"2008","journal-title":"Immunology"},{"key":"2021122010131141800_cei12557-bib-0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0009-9120(97)00049-0","article-title":"Removal of endotoxin from protein preparations","volume":"30","author":"Lui","year":"1997","journal-title":"Clin Biochem"},{"key":"2021122010131141800_cei12557-bib-0046","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3109\/03009740903555374","article-title":"Expression of full-length and splice forms of FOXP3 in rheumatoid arthritis","volume":"39","author":"Ryder","year":"2010","journal-title":"Scand J Rheumatol"},{"key":"2021122010131141800_cei12557-bib-0047","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1600-0463.2011.02848.x","article-title":"FOXP3 mRNA splice forms in synovial CD4+ T cells in rheumatoid arthritis and psoriatic arthritis","volume":"120","author":"Ryder","year":"2011","journal-title":"APMIS"},{"key":"2021122010131141800_cei12557-bib-0048","first-page":"342","article-title":"Systematic method for determining an ideal housekeeping gene for real-time PCR analysis","volume":"19","author":"Mane","year":"2008","journal-title":"J Biomol Tech"},{"key":"2021122010131141800_cei12557-bib-0049","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1189\/jlb.0909631","article-title":"Potent intestinal Th17 priming through peripheral lipopolysaccharide-based immunization","volume":"88","author":"McAleer","year":"2010","journal-title":"J Leukoc Biol"},{"key":"2021122010131141800_cei12557-bib-0050","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jmg.38.12.874","article-title":"Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)","volume":"38","author":"Kobayashi","year":"2001","journal-title":"J Med Genet"},{"key":"2021122010131141800_cei12557-bib-0051","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaci.2007.08.044","article-title":"Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells","volume":"120","author":"Torgerson","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010131141800_cei12557-bib-0052","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1038\/leu.2008.224","article-title":"Malignant Tregs express low molecular splice forms of FOXP3 in Sezary syndrome","volume":"22","author":"Krejsgaard","year":"2008","journal-title":"Leukemia"},{"key":"2021122010131141800_cei12557-bib-0053","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1073\/pnas.0501675102","article-title":"Foxp3 interacts with nuclear factor of activated T cells and NF-\u03baB to repress cytokine gene expression and effector functions of T helper cells","volume":"102","author":"Bettelli","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010131141800_cei12557-bib-0054","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.4049\/jimmunol.180.7.4785","article-title":"Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3","volume":"180","author":"Du","year":"2008","journal-title":"J Immunol"},{"key":"2021122010131141800_cei12557-bib-0055","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature06878","article-title":"TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function","volume":"453","author":"Zhou","year":"2008","journal-title":"Nature"},{"key":"2021122010131141800_cei12557-bib-0056","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM198008073030603","article-title":"Carbimazole and the autoimmune response in Graves' disease","volume":"303","author":"McGregor","year":"1980","journal-title":"N Engl J Med"},{"key":"2021122010131141800_cei12557-bib-0057","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jcem-53-6-1223","article-title":"Inhibition of immunoglobulin-secreting cells by antithyroid cells","volume":"53","author":"Weiss","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2021122010131141800_cei12557-bib-0058","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1124\/jpet.107.132407","article-title":"Thionamides inhibit the transcription factor nuclear factor-\u03baB by suppression of Rac1 and inhibitor of \u03baB kinase \u03b1","volume":"324","author":"Humar","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"2021122010131141800_cei12557-bib-0059","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2174\/1381612013397898","article-title":"The immunomodulatory effects of anti-thyroid drugs are mediated via actions on thyroid cells, affecting thyrocyte\u2013immunocyte signaling: a review","volume":"7","author":"Volpe","year":"2001","journal-title":"Curr Pharm Des"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12557","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/180\/1\/58\/41790935\/cei12557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/180\/1\/58\/41790935\/cei12557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T10:55:17Z","timestamp":1689677717000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/180\/1\/58\/6422125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,3,10]]},"published-print":{"date-parts":[[2015,3,10]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12557","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,4]]},"published":{"date-parts":[[2015,3,10]]}}}