{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:00:47Z","timestamp":1789351247871,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010805","name":"Medical Research Council of South-East Sweden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Type 1 diabetes (T1D) and coeliac disease are both characterized by an autoimmune feature. As T1D and coeliac disease share the same risk genes, patients risk subsequently developing the other disease. This study aimed to investigate the expression of T helper (Th), T cytotoxic (Tc) and regulatory T cells (Treg) in T1D and\/or coeliac disease children in comparison to healthy children. Subgroups of T cells (Th : CD4+ or Tc : CD8+); naive (CD27+CD28+CD45RA+CCR7+), central memory (CD27+CD28+CD45RA\u2212 CCR7+), effector memory (early differentiated; CD27+CD28+CD45RA\u2212 CCR7\u2212 and late differentiated; CD27\u2212 CD28\u2212 CD45RA\u2212 CCR7\u2212), terminally differentiated effector cells (TEMRA; CD27\u2212 CD28\u2212 CD45RA+CCR7\u2212) and Treg (CD4+CD25+FOXP3+CD127\u2212) cells, and their expression of CD39, CD45RA, CD101 and CD129, were studied by flow cytometry in T1D and\/or coeliac disease children or without any of these diseases (reference group). Children diagnosed with both T1D and coeliac disease showed a higher percentage of TEMRA CD4+ cells (P &amp;lt; 0\u00b705), but lower percentages of both early and late effector memory CD8+ cells (P &amp;lt; 0\u00b705) compared to references. Children with exclusively T1D had lower median fluorescence intensity (MFI) of forkhead box protein 3 (FoxP3) (P &amp;lt; 0\u00b705) and also a lower percentage of CD39+ and CD45RA+ within the Treg population (CD4+CD25+FOXP3+CD127\u2212) (P &amp;lt; 0\u00b705). Children with exclusively coeliac disease had a higher MFI of CD101 (P &amp;lt; 0\u00b701), as well as a higher percentage of CD129+ (P &amp;lt; 0\u00b705), in the CD4+CD25hi lymphocyte population, compared to references. In conclusion, children with combined T1D and coeliac disease have a higher percentage of differentiated CD4+ cells compared to CD8+ cells. T1D children show signs of low CD39+\/CD45RA+ Treg cells that may indicate loss of suppressive function. Conversely, children with coeliac disease show signs of CD101+\/CD129+ Treg cells that may indicate suppressor activity.<\/jats:p>","DOI":"10.1111\/cei.12559","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T04:32:32Z","timestamp":1416889952000},"page":"70-82","source":"Crossref","is-referenced-by-count":27,"title":["Low expression of CD39+\/CD45RA+ on regulatory T cells (Treg) cells in type 1 diabetic children in contrast to high expression of CD101+\/CD129+ on Treg cells in children with coeliac disease"],"prefix":"10.1093","volume":"180","author":[{"given":"K","family":"\u00c5kesson","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ryhov County Hospital, J\u00f6nk\u00f6ping, Sweden"},{"name":"Futurum \u2013 the Academy for Health and Care in J\u00f6nk\u00f6ping County Council, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tompa","sequence":"additional","affiliation":[{"name":"Futurum \u2013 the Academy for Health and Care in J\u00f6nk\u00f6ping County Council, J\u00f6nk\u00f6ping, Sweden"},{"name":"The Biomedical Platform, Department of Natural Science and Biomedicine, School of Health Sciences, J\u00f6nk\u00f6ping University, J\u00f6nk\u00f6ping, Sweden"},{"name":"Division of Medical Diagnostics, Ryhov County Hospital, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ryd\u00e9n","sequence":"additional","affiliation":[{"name":"Pacific Northwest Diabetes Research Institute and Type 1 Diabetes R&D Center, Novo Nordisk Inc., Seattle, WA, USA"},{"name":"Division of Paediatrics and Diabetes Research Centre, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Faresj\u00f6","sequence":"additional","affiliation":[{"name":"Futurum \u2013 the Academy for Health and Care in J\u00f6nk\u00f6ping County Council, J\u00f6nk\u00f6ping, Sweden"},{"name":"The Biomedical Platform, Department of Natural Science and Biomedicine, School of Health Sciences, J\u00f6nk\u00f6ping University, J\u00f6nk\u00f6ping, Sweden"},{"name":"Division of Medical Diagnostics, Ryhov County Hospital, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"2021122010131682500_cei12559-bib-0001","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJM198605223142106","article-title":"Type I diabetes mellitus. A chronic autoimmune disease","volume":"314","author":"Eisenbarth","year":"1986","journal-title":"N Engl J Med"},{"key":"2021122010131682500_cei12559-bib-0002","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-3083.1999.00523.x","article-title":"Cytokine profile in coeliac disease","volume":"49","author":"Lahat","year":"1999","journal-title":"Scand J Immunol"},{"key":"2021122010131682500_cei12559-bib-0003","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2249.1994.tb06576.x","article-title":"C-expression of the CD45RA and CD45RO antigens on T lymphocytes in chronic arthritis","volume":"97","author":"Summer","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"2021122010131682500_cei12559-bib-0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs","volume":"99","author":"F\u00f6rster","year":"1999","journal-title":"Cell"},{"key":"2021122010131682500_cei12559-bib-0005","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.95.1.258","article-title":"A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes","volume":"95","author":"Gunn","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010131682500_cei12559-bib-0006","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1074-7613(02)00273-X","article-title":"Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic B cells","volume":"16","author":"Hugues","year":"2002","journal-title":"Immunity"},{"key":"2021122010131682500_cei12559-bib-0007","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/eji.200636656","article-title":"Generalized multi-organ autoimmunity in CCR7-deficient mice","volume":"37","author":"Davalos-Misslitz","year":"2007","journal-title":"Eur J Immunol"},{"key":"2021122010131682500_cei12559-bib-0008","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.4049\/jimmunol.178.7.4112","article-title":"Four functionally distinct populations of human effector-memory CD8+ T lymphocytes","volume":"178","author":"Romero","year":"2007","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0009","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0010","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1172\/JCI19441","article-title":"Induction of Foxp3 and acqustion of T regulaotry activity by stimulated human CD4+CD25\u2013 T cells","volume":"112","author":"Walker","year":"2003","journal-title":"J Clin Invest"},{"key":"2021122010131682500_cei12559-bib-0011","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalysed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"2021122010131682500_cei12559-bib-0012","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1471-2172-13-17","article-title":"Expression of CD39 on FoxP3+ T regulatory cells correlates with pregression of HBV infection","volume":"13","author":"Tang","year":"2012","journal-title":"BMC Immunol"},{"key":"2021122010131682500_cei12559-bib-0013","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.4049\/jimmunol.154.9.4423","article-title":"V7, a novel leukocytes surface protein that participates in T cell activation","volume":"154","author":"Rivas","year":"1995","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0014","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.4049\/jimmunol.179.5.2808","article-title":"CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells","volume":"179","author":"Fernandez","year":"2007","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0015","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.4049\/jimmunol.164.4.1761","article-title":"Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development","volume":"164","author":"De Smedt","year":"2000","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0016","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FOXP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J Exp Med"},{"key":"2021122010131682500_cei12559-bib-0017","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expression the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"2021122010131682500_cei12559-bib-0018","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.immuni.2008.03.016","article-title":"Central role of a defective interleukin-2 production in triggering islet aitoimmune destruction","volume":"28","author":"Tang","year":"2008","journal-title":"Immunity"},{"key":"2021122010131682500_cei12559-bib-0019","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1172\/JCI0213605","article-title":"Multiple immuno-regulatory defects in type-1 diabetes","volume":"1","author":"Kukreja","year":"2002","journal-title":"J Clin Invest"},{"key":"2021122010131682500_cei12559-bib-0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2337\/diabetes.54.1.92","article-title":"Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes","volume":"54","author":"Lindley","year":"2005","journal-title":"Diabetes"},{"key":"2021122010131682500_cei12559-bib-0021","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1365-2249.2008.03810.x","article-title":"Increased resistance of CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes","volume":"154","author":"Lawson","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"2021122010131682500_cei12559-bib-0022","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2337\/db08-1168","article-title":"Expansion of human regulatory T-cells from patients with type 1 diabetes","volume":"58","author":"Putnam","year":"2009","journal-title":"Diabetes"},{"key":"2021122010131682500_cei12559-bib-0023","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/ajg.2011.80","article-title":"IL-15 interferes with suppressive activity of intestinal regualtory T cells expanded in celiac disease","volume":"106","author":"Zanzi","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"2021122010131682500_cei12559-bib-0024","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/00365520802624177","article-title":"Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type 1 diabetes mellitus","volume":"44","author":"Vorobjova","year":"2009","journal-title":"Scand J Gastroent"},{"key":"2021122010131682500_cei12559-bib-0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1196\/annals.1447.018","article-title":"Diverse FOXP3 expression in children with type 1 diabetes and celiac disease","volume":"1150","author":"Kivling","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"2021122010131682500_cei12559-bib-0026","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1399-5448.2009.00568.x","article-title":"Definition, epidemiology and classification of diabetes in children and adolescents","volume":"10","author":"Craig","year":"2009","journal-title":"Ped Diabetes"},{"key":"2021122010131682500_cei12559-bib-0027","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for diagnosis of coeliac disease. Report of working group of European Society of Paediatric Gastroenterology and Nutrition","volume":"65","author":"Walker-Smith","year":"1990","journal-title":"Arch Dis Child"},{"key":"2021122010131682500_cei12559-bib-0028","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mad.2005.11.001","article-title":"Accumulation of memory T cells from childhood to old age: central and effector memroy cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment","volume":"127","author":"Saule","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"2021122010131682500_cei12559-bib-0029","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1742-4933-5-6","article-title":"Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people","volume":"5","author":"Koch","year":"2008","journal-title":"Immun Ageing"},{"key":"2021122010131682500_cei12559-bib-0030","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s10875-011-9573-z","article-title":"Altered proportions of naive, central memory and terminally differentiated central memory subsets among CD4+ and CD8+ T cells expressing CD26 in patients with type 1 diabetes","volume":"31","author":"Matteucci","year":"2011","journal-title":"J Clin Immunol"},{"key":"2021122010131682500_cei12559-bib-0031","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1182\/blood-2002-11-3577","article-title":"Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines","volume":"101","author":"Geginat","year":"2003","journal-title":"Blood"},{"key":"2021122010131682500_cei12559-bib-0032","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2249.2008.03720.x","article-title":"Impaired CD4+ and CD8+ T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children","volume":"153","author":"Hedman","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"2021122010131682500_cei12559-bib-0033","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00125-008-1237-z","article-title":"Accumulation of autoreactive effector T cells and allo-specific regualtory T cells in the pancreas allograft of a type 1 diabetic recipient","volume":"52","author":"Velthuis","year":"2009","journal-title":"Diabetologia"},{"key":"2021122010131682500_cei12559-bib-0034","doi-asserted-by":"publisher","first-page":"645643","DOI":"10.1155\/2011\/645643","article-title":"Lower frequency of CD62L(high) and higher frequency of TNFR2(+) Tregs are associated with inflammatory conditions in type 1 diabtic patients","volume":"2011","author":"Ryba","year":"2011","journal-title":"Mediators Inflamm"},{"key":"2021122010131682500_cei12559-bib-0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.humimm.2013.01.024","article-title":"Loss of the balance between CD4+Foxp3+ regualtory T cells and CD4+IL17A+ Th17 cells in patients with type 1 diabetes","volume":"74","author":"Ryba-Stanislawowska","year":"2013","journal-title":"Hum Immunol"},{"key":"2021122010131682500_cei12559-bib-0036","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.rinim.2011.08.001","article-title":"Efficient expansion of cryopreserved CD4+CD25+CD127lo\/\u2013 cells in type 1 diabetes","volume":"1","author":"Ryd\u00e9n","year":"2011","journal-title":"Results Immunol"},{"key":"2021122010131682500_cei12559-bib-0037","doi-asserted-by":"crossref","first-page":"e56209","DOI":"10.1371\/journal.pone.0056209","article-title":"Foxp3+ Treg expanded from patients with established diabetes reduce helios expression while retaining normal function compared to healthy individuals","volume":"56","author":"Du","year":"2013","journal-title":"PLOS ONE"},{"key":"2021122010131682500_cei12559-bib-0038","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/cei.12116","article-title":"CD4+CD45+RA\u2212FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes","volume":"173","author":"Haseda","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"2021122010131682500_cei12559-bib-0039","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"Borsellino","year":"2007","journal-title":"Blood"},{"key":"2021122010131682500_cei12559-bib-0040","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.4049\/jimmunol.0901881","article-title":"CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis","volume":"183","author":"Fletcher","year":"2009","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0041","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.4049\/jimmunol.0901036","article-title":"The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells","volume":"184","author":"Mittag","year":"2010","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0042","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.humimm.2004.05.016","article-title":"Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans","volume":"66","author":"Morgan","year":"2005","journal-title":"Hum Immunol"},{"key":"2021122010131682500_cei12559-bib-0043","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/intimm\/dxm014","article-title":"Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production","volume":"19","author":"Allan","year":"2007","journal-title":"Int Immunol"},{"key":"2021122010131682500_cei12559-bib-0044","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1182\/blood-2007-06-094656","article-title":"Induction of FOXP3 expression in naive human CD4+FOXP3\u2013 T cells by T-cell receptor stimulation is transforming growth factor-B-dependent but does not confer a regulatory phenotype","volume":"110","author":"Tran","year":"2007","journal-title":"Blood"},{"key":"2021122010131682500_cei12559-bib-0045","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/eji.200636435","article-title":"Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells","volume":"37","author":"Wang","year":"2007","journal-title":"Eur J Immunol"},{"key":"2021122010131682500_cei12559-bib-0046","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.immunol.24.021605.090547","article-title":"FOXP3: of mice and men","volume":"24","author":"Ziegler","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"2021122010131682500_cei12559-bib-0047","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2011.12.012","article-title":"Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells","volume":"36","author":"Miyao","year":"2012","journal-title":"Immunity"},{"key":"2021122010131682500_cei12559-bib-0048","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2337\/diabetes.54.5.1407","article-title":"Functional defects and the influence of age on the frequency of CD4+CD25+ T-cells in type 1 diabetes","volume":"54","author":"Brusko","year":"2005","journal-title":"Diabetes"},{"key":"2021122010131682500_cei12559-bib-0049","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.4049\/jimmunol.181.10.7350","article-title":"The effector T cells of diabetic subjects are resistant to regulation via CD4+FOXP3+regulatory T cells","volume":"181","author":"Schneider","year":"2008","journal-title":"J Immunol"},{"key":"2021122010131682500_cei12559-bib-0050","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/07357909309011682","article-title":"Interleukin-9: a T-cell growth factor with a potential oncogenic activity","volume":"11","author":"Renauld","year":"1993","journal-title":"Cancer Invest"},{"key":"2021122010131682500_cei12559-bib-0051","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1038\/ajg.2013.303","article-title":"Immunoregulatory pathways are active in the small intestinal mucosa of patients with potential celiac disease","volume":"108","author":"Borrelli","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"2021122010131682500_cei12559-bib-0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ctg.2012.22","article-title":"Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal \u2018immunological niche\u2019 in coeliac disease after gluten-free diet","volume":"3","author":"Cianci","year":"2012","journal-title":"Clin Transl Gastroenterol"},{"key":"2021122010131682500_cei12559-bib-0053","doi-asserted-by":"crossref","first-page":"e68432","DOI":"10.1371\/journal.pone.0068432","article-title":"Changes in natural Foxp3+Treg but not mucosally-imprinted CD62LnegCD38+Foxp3+Treg in the circulation of celiac disease patients","volume":"8","author":"van Leeuwen","year":"2013","journal-title":"PLOS ONE"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/180\/1\/70\/41791341\/cei12559.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/180\/1\/70\/41791341\/cei12559.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T13:55:09Z","timestamp":1689688509000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/180\/1\/70\/6422108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,3,10]]},"published-print":{"date-parts":[[2015,3,10]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12559","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,4]]},"published":{"date-parts":[[2015,3,10]]}}}