{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:41:16Z","timestamp":1789389676087,"version":"build-2803163510"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"G.O.A. Catholic University Leuven","award":["GOA\/13\/013"],"award-info":[{"award-number":["GOA\/13\/013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Polysaccharide antibody deficiency is characterized by a poor or absent antibody response after vaccination with an unconjugated pneumococcal polysaccharide vaccine. Allohaemagglutinins (AHA) are antibodies to A or B polysaccharide antigens on the red blood cells, and are often used as an additional or alternative measure to assess the polysaccharide antibody response. However, few studies have been conducted to establish the clinical significance of AHA. To investigate the value of AHA to diagnose a polysaccharide antibody deficiency, pneumococcal polysaccharide antibody titres and AHA were studied retrospectively in 180 subjects in whom both tests had been performed. Receiver operating characteristic curves for AHA\u2005versus the pneumococcal vaccine response as a marker for the anti-polysaccharide immune response revealed an area under the curve between 0\u00b75 and 0\u00b7573. Sensitivity and specificity of AHA to detect a polysaccharide antibody deficiency, as diagnosed by vaccination response, were low (calculated for cut-off 1\/4\u20131\/32). In subjects with only low pneumococcal antibody response, the prevalence of bronchiectasis was significantly higher than in subjects with only low AHA (45\u00b75 and 1\u00b73%, respectively) or normal pneumococcal antibody response and AHA (2\u00b74%). A logistic regression model showed that low pneumococcal antibody response but not AHA was associated with bronchiectasis (odds ratio 46\u00b72). The results of this study do not support the routine use of AHA to assess the polysaccharide antibody response in patients with suspected immunodeficiency, but more studies are warranted to clarify the subject further.<\/jats:p>","DOI":"10.1111\/cei.12571","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T06:16:43Z","timestamp":1418797003000},"page":"271-279","source":"Crossref","is-referenced-by-count":14,"title":["Value of allohaemagglutinins in the diagnosis of a polysaccharide antibody deficiency"],"prefix":"10.1093","volume":"180","author":[{"given":"H","family":"Schaballie","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University Hospitals Leuven, Leuven, Belgium"},{"name":"Department Microbiology and Immunology, KU Leuven \u2013 University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Department of 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