{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:39Z","timestamp":1787013999697,"version":"build-2736575974"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,4,14]],"date-time":"2015-04-14T00:00:00Z","timestamp":1428969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The National Institute for Diabetes, Digestive and Kidney Disorders","award":["R01-DK07553"],"award-info":[{"award-number":["R01-DK07553"]}]},{"DOI":"10.13039\/100000060","name":"The National Institute of Allergy and Infectious Diseases","doi-asserted-by":"crossref","award":["R01-AI092117"],"award-info":[{"award-number":["R01-AI092117"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Serbian Ministry of Education and Science","award":["175085"],"award-info":[{"award-number":["175085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The mechanism responsible for trafficking of monocyte-derived macrophages into kidney in the puromycin aminonucleoside model of nephrotic syndrome in rats (PAN-NS), and the significance of this infiltration, remain largely unknown. CXCL10, a chemokine secreted in many T helper type 1 (Th1) inflammatory diseases, exhibits important roles in trafficking of monocytes and activated T cells. We hypothesized that induction of circulating interferon (IFN)-\u03b3 and glomerular tumour necrosis factor (TNF)-\u03b1 during PAN-NS would stimulate the release of CXCL10 by podocytes, leading to infiltration of activated immune cells and greater glomerular injury. We found that serum IFN-\u03b3, glomerular Cxcl10\u2005mRNA and intra- and peri-glomerular macrophage infiltration were induced strongly during the late acute phase of PAN-NS in Wistar rats, but not in nude (Foxn1rnu\/rnu) rats lacking functional effector T lymphocytes. Wistar rats also developed significantly greater proteinuria than nude rats, which could be abolished by macrophage depletion. Stimulation of cultured podocytes with both IFN-\u03b3 and TNF-\u03b1 markedly induced the expression of Cxcl10\u2005mRNA and CXCL10 secretion. Together, these data support our hypothesis that increased circulating IFN-\u03b3 and glomerular TNF-\u03b1 induce synergistically the production and secretion of CXCL10 by podocytes, attracting activated macrophages into kidney tissue. The study also suggests that IFN-\u03b3, secreted from Th1 lymphocytes, may prime proinflammatory macrophages that consequently aggravate renal injury.<\/jats:p>","DOI":"10.1111\/cei.12579","type":"journal-article","created":{"date-parts":[[2015,1,6]],"date-time":"2015-01-06T03:25:28Z","timestamp":1420514728000},"page":"305-315","source":"Crossref","is-referenced-by-count":72,"title":["CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis"],"prefix":"10.1093","volume":"180","author":[{"given":"D","family":"Petrovic-Djergovic","sequence":"first","affiliation":[{"name":"Centers for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Popovic","sequence":"additional","affiliation":[{"name":"Centers for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department for Radiobiology and Molecular Genetics, Vin\u010da Institute, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Chittiprol","sequence":"additional","affiliation":[{"name":"Centers for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Cortado","sequence":"additional","affiliation":[{"name":"Centers for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R F","family":"Ransom","sequence":"additional","affiliation":[{"name":"Centers for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University 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