{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:26:41Z","timestamp":1790195201773,"version":"4.1.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,4,3]],"date-time":"2015-04-03T00:00:00Z","timestamp":1428019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Presidium of the Russian Academy of Sciences program \u2018Fundamental Sciences for Medicine\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,15]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Host genetic variations may influence a changing profile of biochemical markers and outcome in patients with trauma\/injury. The objective of this study was to assess clinical associations of single nucleotide polymorphisms (SNPs) in the genes of cytokines in critically ill patients. A total of 430 patients were genotyped for SNPs in the genes of pro- (IL1B, IL6, IL8) and anti-inflammatory (IL4, IL10, IL13) cytokines. The main end-points were sepsis, mortality and adult respiratory distress syndrome (ARDS). We evaluated the dynamic levels of bilirubin, blood urea nitrogen, creatine kinase, creatinine and lactate dehydrogenase in five points of measurements (between 1 and 14\u00a0days after admission) and correlated them with SNPs. High-producing alleles of proinflammatory cytokines protected patients against sepsis (IL1B \u2212511A and IL8 \u2014251A) and mortality (IL1B \u2212511A). High-producing alleles of anti-inflammatory cytokines IL4 \u2014589T and IL13 431A (144Gln) were less frequent in ARDS patients. The carriers of IL6 \u2014174C\/C genotypes were prone to the increased levels of biochemical markers and acute kidney and liver insufficiency. Genotype-dependent differences in the levels of biochemical indicators gradually increased to a maximal value on the 14th day after admission. These findings suggest that genetic variability in pro- and anti-inflammatory cytokines may contribute to different clinical phenotypes in patients at high risk of critical illness.<\/jats:p>","DOI":"10.1111\/cei.12592","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T23:55:58Z","timestamp":1422057358000},"page":"531-541","source":"Crossref","is-referenced-by-count":17,"title":["Clinical associations of host genetic variations in the genes of cytokines in critically ill patients"],"prefix":"10.1093","volume":"180","author":[{"given":"O B","family":"Belopolskaya","sequence":"first","affiliation":[{"name":"N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T V","family":"Smelaya","sequence":"additional","affiliation":[{"name":"V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V V","family":"Moroz","sequence":"additional","affiliation":[{"name":"V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Golubev","sequence":"additional","affiliation":[{"name":"V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L E","family":"Salnikova","sequence":"additional","affiliation":[{"name":"N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia"},{"name":"V. A. Negovsky Research Institute of General Reanimatology, Russian Academy of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,3]]},"reference":[{"key":"2021122010145217200_cei12592-bib-0001","doi-asserted-by":"crossref","first-page":"321S","DOI":"10.1378\/chest.112.6_Supplement.321S","article-title":"Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock","volume":"112","author":"Dinarello","year":"1997","journal-title":"Chest"},{"key":"2021122010145217200_cei12592-bib-0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/1381612033392567","article-title":"Cytokine therapeutics for the treatment of sepsis: why has nothing worked?","volume":"9","author":"Remick","year":"2003","journal-title":"Curr Pharm Des"},{"key":"2021122010145217200_cei12592-bib-0003","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful 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