{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:18:10Z","timestamp":1787314690560,"version":"build-2736575974"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 11420090100389"],"award-info":[{"award-number":["PIP 11420090100389"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.<\/jats:p>","DOI":"10.1111\/cei.12601","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T14:25:06Z","timestamp":1423751106000},"page":"118-125","source":"Crossref","is-referenced-by-count":43,"title":["Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome"],"prefix":"10.1093","volume":"181","author":[{"given":"J R","family":"Ferraris","sequence":"first","affiliation":[{"name":"Pediatric Nephrology Service, Hospital Italiano"},{"name":"Department of Pediatrics, School of Medicine, University of Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Ferraris","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Service, Hospital Italiano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A B","family":"Acquier","sequence":"additional","affiliation":[{"name":"Pharmacology Unit, School of Dentistry, University of Buenos Aires"},{"name":"Institute for Biomedical Research (INBIOMED), School of Medicine, University of Buenos Aires and National Scientific and Technical Research Council"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P B","family":"Sorroche","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hospital Italiano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M S","family":"Saez","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hospital Italiano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ginaca","sequence":"additional","affiliation":[{"name":"Immunology Service, Hospital de Ni\u00f1os Ricardo Gutierrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C F","family":"Mendez","sequence":"additional","affiliation":[{"name":"Pharmacology Unit, School of Dentistry, University of Buenos Aires"},{"name":"Institute for Biomedical Research (INBIOMED), School of Medicine, University of Buenos Aires and National Scientific and Technical Research Council"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"2021122010160539200_cei12601-bib-0001","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s004670050248","article-title":"Childhood hemolytic uremic syndrome in Argentina: long-term follow-up and prognostic features","volume":"11","author":"Spizzirri","year":"1997","journal-title":"Pediatr Nephrol"},{"key":"2021122010160539200_cei12601-bib-0002","first-page":"27","article-title":"The epidemiology of hemolytic uremic syndrome in Argentina. 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