{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:40:37Z","timestamp":1789602037841,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:00:00Z","timestamp":1431561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"IZKF Aachen","award":["E6-7"],"award-info":[{"award-number":["E6-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (Treg) and effector T cells in the periphery. Previously, we identified the cAMP-responsive element modulator \u03b1 (CREM\u03b1) as a major factor responsible for decreased IL-2 production in T cells from SLE patients. Additionally, using a transgenic mouse that specifically over-expresses CREM\u03b1 in T cells (CD2CREM\u03b1tg), we provided in-vivo evidence that CREM\u03b1 indeed suppresses IL-2 production. To analyse the effects of CREM\u03b1 in an autoimmune prone mouse model we introduced a Fas mutation in the CD2CREM\u03b1tg mice (FVB\/Fas\u2013\/\u2013CD2CREM\u03b1tg). Overexpression of CREM\u03b1 strongly accelerated the lymphadenopathy and splenomegaly in the FVB\/Fas\u2013\/\u2013 mice. This was accompanied by a massive expansion of double-negative (DN) T cells, enhanced numbers of interferon (IFN)-\u03b3-producing T cells and reduced percentages of Tregs. Treatment of FVB\/Fas\u2013\/\u2013CD2CREM\u03b1tg mice with IL-2 restored the percentage of Tregs and reversed increased IFN-\u03b3 production, but did not affect the number of DNTs. Our data indicate that CREM\u03b1 contributes to the failure of tolerance in SLE by favouring effector T cells and decreasing regulatory T cells, partially mediated by repression of IL-2 in vivo.<\/jats:p>","DOI":"10.1111\/cei.12629","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T18:08:00Z","timestamp":1427479680000},"page":"76-86","source":"Crossref","is-referenced-by-count":27,"title":["Interleukin-2 treatment reverses effects of cAMP-responsive element modulator \u03b1-over-expressing T cells in autoimmune-prone mice"],"prefix":"10.1093","volume":"181","author":[{"given":"K","family":"Ohl","sequence":"first","affiliation":[{"name":"Department of Pediatrics, RWTH Aachen, Aachen, Germany"},{"name":"IZKF Aachen, Medical Faculty, RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wiener","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Schippers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tenbrock","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, RWTH Aachen, Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,5,14]]},"reference":[{"key":"2021122010164562900_cei12629-bib-0001","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molmed.2009.12.005","article-title":"Pathogenesis of human systemic lupus erythematosus: recent advances","volume":"16","author":"Crispin","year":"2010","journal-title":"Trends Mol Med"},{"key":"2021122010164562900_cei12629-bib-0002","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J Med"},{"key":"2021122010164562900_cei12629-bib-0003","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0167-5699(00)01675-3","article-title":"Etiopathogenesis of systemic lupus erythematosus","volume":"21","author":"Herrmann","year":"2000","journal-title":"Immunol Today"},{"key":"2021122010164562900_cei12629-bib-0004","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.molmed.2013.02.001","article-title":"cAMP responsive element modulator: a critical regulator of cytokine production","volume":"19","author":"Rauen","year":"2013","journal-title":"Trends Mol Med"},{"key":"2021122010164562900_cei12629-bib-0005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0079-6603(00)64009-6","article-title":"Transcriptional regulation by cyclic AMP-responsive factors","volume":"64","author":"De Cesare","year":"2000","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"2021122010164562900_cei12629-bib-0006","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.cb.11.110195.002035","article-title":"Transcription factors responsive to cAMP","volume":"11","author":"Sassone-Corsi","year":"1995","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2021122010164562900_cei12629-bib-0007","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0092-8674(91)90503-Q","article-title":"CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription","volume":"64","author":"Foulkes","year":"1991","journal-title":"Cell"},{"key":"2021122010164562900_cei12629-bib-0008","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jmcb\/mjs004","article-title":"CREMalpha overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity","volume":"4","author":"Lippe","year":"2012","journal-title":"J Mol Cell Biol"},{"key":"2021122010164562900_cei12629-bib-0009","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.4049\/jimmunol.1203147","article-title":"Overexpression of CREMalpha in T cells aggravates lipopolysaccharide-induced acute lung injury","volume":"191","author":"Verjans","year":"2013","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J Exp Med"},{"key":"2021122010164562900_cei12629-bib-0011","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J Exp Med"},{"key":"2021122010164562900_cei12629-bib-0012","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1073\/pnas.1103782108","article-title":"CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis","volume":"108","author":"McNally","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010164562900_cei12629-bib-0013","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.175.7.4180","article-title":"Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells","volume":"175","author":"Lim","year":"2005","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0014","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat Immunol"},{"key":"2021122010164562900_cei12629-bib-0015","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse","volume":"27","author":"Brunkow","year":"2001","journal-title":"Nat Genet"},{"key":"2021122010164562900_cei12629-bib-0016","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"2021122010164562900_cei12629-bib-0017","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/83707","article-title":"X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy","volume":"27","author":"Wildin","year":"2001","journal-title":"Nat Genet"},{"key":"2021122010164562900_cei12629-bib-0018","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/annrheumdis-2012-202216","article-title":"Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus","volume":"72","author":"Alexander","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2021122010164562900_cei12629-bib-0019","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1002\/art.38119","article-title":"The percentage of Foxp3 Helios T regulatory cells positively correlates with disease activity in systemic lupus erythematosus","volume":"65","author":"Golding","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2021122010164562900_cei12629-bib-0020","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1136\/ard.2011.153619","article-title":"Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic lupus erythematosus","volume":"70","author":"Engler","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"2021122010164562900_cei12629-bib-0021","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1073\/pnas.0903158107","article-title":"Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus","volume":"107","author":"Humrich","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122010164562900_cei12629-bib-0022","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.clim.2011.08.005","article-title":"Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus","volume":"141","author":"Dolff","year":"2011","journal-title":"Clin Immunol"},{"key":"2021122010164562900_cei12629-bib-0023","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.4049\/jimmunol.177.3.1451","article-title":"Suppression of disease in New Zealand Black\/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells","volume":"177","author":"Scalapino","year":"2006","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0024","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/ar4188","article-title":"CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice","volume":"15","author":"Weigert","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"2021122010164562900_cei12629-bib-0025","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"2021122010164562900_cei12629-bib-0026","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1084\/jem.20041982","article-title":"Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization","volume":"201","author":"Setoguchi","year":"2005","journal-title":"J Exp Med"},{"key":"2021122010164562900_cei12629-bib-0027","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ni1264","article-title":"Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling","volume":"6","author":"D'Cruz","year":"2005","journal-title":"Nat Immunol"},{"key":"2021122010164562900_cei12629-bib-0028","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/eji.200838190","article-title":"Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15","volume":"38","author":"Yang","year":"2008","journal-title":"Eur J Immunol"},{"key":"2021122010164562900_cei12629-bib-0029","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.0959-9673.2005.00438.x","article-title":"Elimination of CD4(+)CD25(+) T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB x NZW F mice","volume":"86","author":"Hayashi","year":"2005","journal-title":"Int J Exp Pathol"},{"key":"2021122010164562900_cei12629-bib-0030","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4049\/jimmunol.134.2.852","article-title":"Treatment of murine lupus with monoclonal anti-T cell antibody","volume":"134","author":"Wofsy","year":"1985","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0031","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.4049\/jimmunol.166.6.4216","article-title":"Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus","volume":"166","author":"Solomou","year":"2001","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0032","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1074\/jbc.M113.523605","article-title":"cAMP responsive element modulator (CREM) alpha mediates chromatin remodeling of CD8 during the generation of CD3+ CD4\u2013 CD8\u2013 T cells","volume":"289","author":"Hedrich","year":"2014","journal-title":"J Biol Chem"},{"key":"2021122010164562900_cei12629-bib-0033","doi-asserted-by":"crossref","first-page":"271694","DOI":"10.1155\/2011\/271694","article-title":"Murine models of systemic lupus erythematosus","volume":"2011","author":"Perry","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"2021122010164562900_cei12629-bib-0034","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.4049\/jimmunol.144.10.3756","article-title":"The expanded populations of CD4\u2013CD8\u2013 T cell receptor alpha\/beta+ T cells associated with the lpr and gld mutations are CD2","volume":"144","author":"Shirai","year":"1990","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0035","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crispin","year":"2008","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0036","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4049\/jimmunol.143.1.103","article-title":"T cell receptor alpha\/beta expressing double-negative (CD4\u2013\/CD8\u2013) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis","volume":"143","author":"Shivakumar","year":"1989","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0037","doi-asserted-by":"crossref","first-page":"31880","DOI":"10.1074\/jbc.M113.508655","article-title":"cAMP-responsive element modulator alpha (CREMalpha) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4\u2013CD8\u2013 T cells in health and disease","volume":"288","author":"Hedrich","year":"2013","journal-title":"J Biol Chem"},{"key":"2021122010164562900_cei12629-bib-0038","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1172\/JCI750","article-title":"Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice","volume":"101","author":"Balomenos","year":"1998","journal-title":"J Clin Invest"},{"key":"2021122010164562900_cei12629-bib-0039","doi-asserted-by":"crossref","first-page":"540","DOI":"10.4049\/jimmunol.1400931","article-title":"IL-17 promotes murine lupus","volume":"193","author":"Amarilyo","year":"2014","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0040","doi-asserted-by":"crossref","first-page":"125sr1","DOI":"10.1126\/scitranslmed.3003504","article-title":"Treating human autoimmunity: current practice and future prospects","volume":"4","author":"Rosenblum","year":"2012","journal-title":"Sci Transl Med"},{"key":"2021122010164562900_cei12629-bib-0041","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.154.3.791","article-title":"Analysis of T cell function in autoimmune murine strains. Defects in production and responsiveness to interleukin 2","volume":"154","author":"Altman","year":"1981","journal-title":"J Exp Med"},{"key":"2021122010164562900_cei12629-bib-0042","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1084\/jem.154.5.1671","article-title":"Deficient interleukin 2 activity in MRL\/Mp and C57BL\/6J mice bearing the lpr gene","volume":"154","author":"Wofsy","year":"1981","journal-title":"J Exp Med"},{"key":"2021122010164562900_cei12629-bib-0043","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.4049\/jimmunol.130.6.2651","article-title":"Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE)","volume":"130","author":"Linker-Israeli","year":"1983","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0044","first-page":"161","article-title":"Impaired IL2 production by lymphocytes of patients with systemic lupus erythematosus","volume":"135D","author":"de Faucal","year":"1984","journal-title":"Ann Immunol (Paris)"},{"key":"2021122010164562900_cei12629-bib-0045","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1172\/JCI110579","article-title":"Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus","volume":"69","author":"Alcocer-Varela","year":"1982","journal-title":"J Clin Invest"},{"key":"2021122010164562900_cei12629-bib-0046","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.4049\/jimmunol.170.6.2971","article-title":"The cyclic adenosine 5\u2032-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism","volume":"170","author":"Tenbrock","year":"2003","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0047","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.4049\/jimmunol.169.8.4147","article-title":"Antisense cyclic adenosine 5\u2032-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus","volume":"169","author":"Tenbrock","year":"2002","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0048","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1074\/jbc.M110.166785","article-title":"Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus","volume":"286","author":"Juang","year":"2011","journal-title":"J Biol Chem"},{"key":"2021122010164562900_cei12629-bib-0049","first-page":"A387","article-title":"SLE serum IgG increases CREM binding to the IL-2 promoter and suppress IL-2 production through CaMKIV","volume":"19","author":"Juang","year":"2005","journal-title":"FASEB J"},{"key":"2021122010164562900_cei12629-bib-0050","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.4049\/jimmunol.1400977","article-title":"IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells","volume":"193","author":"Mizui","year":"2014","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0051","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.4049\/jimmunol.0901163","article-title":"Cutting edge: regulatory T cells directly suppress B cells in systemic lupus erythematosus","volume":"183","author":"Iikuni","year":"2009","journal-title":"J Immunol"},{"key":"2021122010164562900_cei12629-bib-0052","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2005-11-4502","article-title":"Activated CD4+CD25+ T cells selectively kill B lymphocytes","volume":"107","author":"Zhao","year":"2006","journal-title":"Blood"},{"key":"2021122010164562900_cei12629-bib-0053","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1136\/annrheumdis-2014-206506","article-title":"Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE","volume":"74","author":"Humrich","year":"2015","journal-title":"Ann Rheumatic Dis"},{"key":"2021122010164562900_cei12629-bib-0054","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1172\/JCI73411","article-title":"CaMK4-dependent activation of AKT\/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance","volume":"124","author":"Koga","year":"2014","journal-title":"J Clin Invest"},{"key":"2021122010164562900_cei12629-bib-0055","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3109\/08916934.2014.915954","article-title":"KN-93, an inhibitor of calcium\/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3 regulatory T cells in MRL\/lpr mice","volume":"47","author":"Koga","year":"2014","journal-title":"Autoimmunity"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cei.12629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cei.12629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/181\/1\/76\/41791505\/cei12629.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/181\/1\/76\/41791505\/cei12629.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T21:29:43Z","timestamp":1691530183000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/181\/1\/76\/6422188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,14]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,14]]},"published-print":{"date-parts":[[2015,6,5]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12629","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,7]]},"published":{"date-parts":[[2015,5,14]]}}}