{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:09:31Z","timestamp":1760267371345},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,5,10]],"date-time":"2015-05-10T00:00:00Z","timestamp":1431216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Group against Systemic Sclerosis"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Human leucocyte antigen (HLA)-G has a tolerogenic function and could play a role in the pathogenesis of immune-mediated diseases, including systemic sclerosis (SSc). The aim of this study was to evaluate HLA-G serum expression (sHLA-G) and the HLA-G gene 14 base pairs (bp) insertion\/deletion (del\u2212\/del+) polymorphism in patients with Ssc, to search for possible associations with clinical and laboratory variables. sHLA-G was measured by enzyme-linked immunosorbent assay (ELISA) in sera from 77 patients with SSc and 32 healthy donors (HD); the 14 bp del\u2212\/del+ polymorphism was evaluated by polymerase chain reaction (PCR) amplification of peripheral blood mononuclear cells (PBMC) genomic DNA. Receiver operating characteristics (ROC) analysis identified the HLA-G cut-off that best discriminated dichotomized clinical and serological variables, that was subsequently employed to subdivide SSc patients into HLA-G high (HLA-G+) and low (HLA-G\u2212) profile groups. sHLA-G were not statistically different between SSc patients and HD, nor between distinct SSc autoantibody subsets. Subdividing SSc patients by HLA-G positivity or negativity yielded significant differences for the modified Rodnan skin score (mRss) (P = 0\u00b7032), \u2018general\u2019 (P = 0\u00b7031) and \u2018kidney\u2019 (P = 0\u00b7028) Medsger severity scores (MSS) and disease activity index, and especially \u0394 heart\/lung (P = 0\u00b7005). A worse \u2018general\u2019 MSS (P = 0\u00b7002) and \u0394 heart\/lung (P = 0\u00b7011) were more frequent in the low sHLA-G group. These two variables and mRss were associated with sHLA-G levels at logistic regression analysis. Treatment had no influence on sHLA-G. Moreover, a higher frequency of scleredema was detected in the del+\/del+ than the del-\/del+ group (P = 0.04). These data suggest modulatory effects of sHLA-G on SSc. Prospective studies are needed to investigate a role in predicting the disease course.<\/jats:p>","DOI":"10.1111\/cei.12633","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T14:14:44Z","timestamp":1428156884000},"page":"100-109","source":"Crossref","is-referenced-by-count":13,"title":["Clinical correlates of human leucocyte antigen (HLA)-G in systemic sclerosis"],"prefix":"10.1093","volume":"181","author":[{"given":"E","family":"Favoino","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I E","family":"Favia","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Vettori","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Internal Medicine \u2018F. Magrassi, A. Lanzara\u2019-Rheumatology Section, Second University of Naples, Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Vicenti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology (DIMO), Rheumatologic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Valentini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Internal Medicine \u2018F. Magrassi, A. 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