{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:30:21Z","timestamp":1769841021980,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Ministry of the University and Scientific Research of Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The aim of this study was to elucidate more clearly the role of interleukin (IL)-18 in modulating the IL-22 pathway in primary Sj\u00f6gren's syndrome (pSS) patients and in pSS-associated lymphomas. Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sialoadenitis (nSCS), parotid glands biopsies from non-Hodgkin lymphomas (NHL) developed in pSS patients, were evaluated for IL-18, IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and signal transducer and activator of transcription-3 (STAT-3) expression. MSGs IL-22R1-expressing cells were characterized by confocal microscopy and flow cytometry in pSS, nSCS and healthy controls. The effect of recombinant IL-18 and IL-22 on peripheral blood mononuclear cells (PBMCs) from pSS and nSCS was studied by flow cytometry and reverse transcription\u2013polymerase chain reaction (RT-PCR). MSGs of pSS and NHL were characterized by an imbalance between IL-22 and IL-22BP protein expression, with IL-18 and IL-22BP being expressed in a mutually exclusive manner and IL-18 and IL-22R1 being correlated directly. Aberrant expression of IL-22R1, induced by IL-18, was observed only among tissue and circulating myeloid cells of pSS patients and macrophages of NHL tissues of pSS patients, but not nSCS. IL-22R1 expression on PBMC of pSS was functional, as its stimulation with recombinant IL-22 significantly up-regulated the expression of STAT-3, IL-17 and IL-22. An IL-18-dependent aberrant expression of IL-22R1 on cells of haematopoietic origin seems to be a specific immunological signature of patients with pSS and pSS-associated lymphomas.<\/jats:p>","DOI":"10.1111\/cei.12643","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T09:01:40Z","timestamp":1429174900000},"page":"219-229","source":"Crossref","is-referenced-by-count":40,"title":["Interleukin (IL)-22 receptor 1 is over-expressed in primary Sjogren's syndrome and Sj\u00f6gren-associated non-Hodgkin lymphomas and is regulated by IL-18"],"prefix":"10.1093","volume":"181","author":[{"given":"F","family":"Ciccia","sequence":"first","affiliation":[{"name":"Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Guggino","sequence":"additional","affiliation":[{"name":"Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Palermo, Italy"},{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit\u00e0 di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Ospedali riuniti Villa Sofia-Cervello, Anatomia Patologica, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit\u00e0 di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Carubbi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Sezione di Reumatologia, Universit\u00e0 di L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Cannizzaro","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Ospedali riuniti Villa Sofia-Cervello, Anatomia Patologica, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Sireci","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit\u00e0 di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Dieli","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit\u00e0 di Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Campisi","sequence":"additional","affiliation":[{"name":"Dipartimento di discipline Chirurgiche, Universit\u00e0 di Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Sezione di Reumatologia, Universit\u00e0 di L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Sezione di Reumatologia, Universit\u00e0 di L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"De Leo","sequence":"additional","affiliation":[{"name":"Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universit\u00e0 di Palermo, Palermo, 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