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Although major progress has been made in elucidating the molecular mechanisms responsible for autoimmunity, current therapies for lupus have not improved considerably. Because the exposure of carbon monoxide (CO) has been shown to display beneficial immunoregulatory properties in different immune-mediated diseases, we investigated whether CO therapy improves lupus-related kidney injury in lupus mice. MRL-Faslpr lupus mice were exposed to CO and disease progression was evaluated. ANA, leucocyte-infiltrating populations in spleen, kidney and lung and kidney lesions, were measured. CO therapy significantly decreased the frequency of activated B220+ CD4\u2212 CD8\u2212 T cells in kidneys and lungs, as well as serum levels of ANA. Furthermore, we observed that CO therapy reduced kidney injury by decreasing proliferative glomerular damage and immune complexes deposition, decreased proinflammatory cytokine production and finally delayed the impairment of kidney function. CO exposure ameliorates kidney and lung leucocyte infiltration and delays kidney disease in MRL-Faslpr lupus mice. Our data support the notion that CO could be explored as a potential new therapy for lupus nephritis.<\/jats:p>","DOI":"10.1111\/cei.12657","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T08:30:14Z","timestamp":1434961814000},"page":"1-13","source":"Crossref","is-referenced-by-count":30,"title":["Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus"],"prefix":"10.1093","volume":"182","author":[{"given":"J P","family":"Mackern-Oberti","sequence":"first","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Microbiolog\u00eda y Gen\u00e9tica Molecular, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Institute of Medicine and Experimental Biology of Cuyo (IMBECU), Science and Technology Center (CCT) of Mendoza, National Council of Scientific and Technical Research (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Obreque","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Inmunolog\u00eda Cl\u00ednica y Reumatolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Patol\u00f3gica, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Llanos","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Inmunolog\u00eda Cl\u00ednica y Reumatolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Kalergis","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Microbiolog\u00eda y Gen\u00e9tica Molecular, Facultad de Ciencias Biol\u00f3gicas, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Departamento de Inmunolog\u00eda Cl\u00ednica y Reumatolog\u00eda, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"INSERM UMR 1064-Center for Research in Transplantation and Immunology, Nantes, 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