{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:11:28Z","timestamp":1789823488467,"version":"4.0.1"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008367","name":"SNF","doi-asserted-by":"publisher","award":["SNSF 310030_153059"],"award-info":[{"award-number":["SNSF 310030_153059"]}],"id":[{"id":"10.13039\/100008367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The Swiss National Registry for Primary Immunodeficiency Disorders (PID) was established in 2008, constituting a nationwide network of paediatric and adult departments involved in the care of patients with PID at university medical centres, affiliated teaching hospitals and medical institutions. The registry collects anonymized clinical and genetic information on PID patients and is set up within the framework of the European database for PID, run by the European Society of Immunodeficiency Diseases. To date, a total of 348 patients are registered in Switzerland, indicating an estimated minimal prevalence of 4\u00b72 patients per 100 000 inhabitants. Distribution of different PID categories, age and gender are similar to the European cohort of currently 19 091 registered patients: \u2018predominantly antibody disorders\u2019 are the most common diseases observed (n = 217\/348, 62%), followed by \u2018phagocytic disorders\u2019 (n = 31\/348, 9%). As expected, \u2018predominantly antibody disorders\u2019 are more prevalent in adults than in children (78 versus 31%). Within this category, \u2018common variable immunodeficiency disorder\u2019 (CVID) is the most prevalent PID (n = 98\/217, 45%), followed by \u2018other hypogammaglobulinaemias\u2019 (i.e. a group of non-classified hypogammaglobulinaemias) (n = 54\/217, 25%). Among \u2018phagocytic disorders\u2019, \u2018chronic granulomatous disease\u2019 is the most prevalent PID (n = 27\/31, 87%). The diagnostic delay between onset of symptoms and diagnosis is high, with a median of 6 years for CVID and more than 3 years for \u2018other hypogammaglobulinaemias\u2019.<\/jats:p>","DOI":"10.1111\/cei.12661","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T14:23:33Z","timestamp":1433168613000},"page":"45-50","source":"Crossref","is-referenced-by-count":52,"title":["The Swiss National Registry for Primary Immunodeficiencies: report on the first 6 years\u2019 activity from 2008 to 2014"],"prefix":"10.1093","volume":"182","author":[{"given":"K","family":"Marschall","sequence":"first","affiliation":[{"name":"Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hoernes","sequence":"additional","affiliation":[{"name":"Division of Immunology, University Children's Hospital Zurich and Children's Research Centre, University Zurich, Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bitzenhofer-Gr\u00fcber","sequence":"additional","affiliation":[{"name":"Division of Allergology, University Hospital Berne, Berne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Jandus","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergology, University Hospital Geneva, Geneva"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Duppenthaler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University Children's Hospital Berne, Berne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"Wuillemin","sequence":"additional","affiliation":[{"name":"Division of Haematology and Central Haematology Laboratory, Luzerner Kantonsspital and University of Berne, Berne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rischewski","sequence":"additional","affiliation":[{"name":"Division of Oncology\/Haematology, Children's Hospital Lucerne, Lucerne"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Boyman","sequence":"additional","affiliation":[{"name":"Division of Immunology, University Hospital Zurich, Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Heininger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University Children's Hospital Basel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Hauser","sequence":"additional","affiliation":[{"name":"IZZ Immunology-Zentrum Z\u00fcrich, Zurich"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Steiner","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergology, Spital Tiefenau Berne, 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