{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:04:00Z","timestamp":1789376640540,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Pontificia Universidad Javeriana Bogot\u00e1, Colombia","award":["ID. 4149"],"award-info":[{"award-number":["ID. 4149"]}]},{"name":"Pontificia Universidad Javeriana Bogot\u00e1, Colombia","award":["ID. 3128"],"award-info":[{"award-number":["ID. 3128"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,13]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) is a persistent virus with oncogenic capacity that has been implicated in the development of aggressive B cell lymphomas, primarily in immunosuppressed individuals, although it can be present in immunocompetent individuals. Changes in the function and clonal diversity of T lymphocytes might be implied by viral persistence and lymphoma development. The aim of the present study was to evaluate the frequency, phenotype, function and clonotypical distribution of EBV-specific T cells after peripheral blood stimulation with a virus lysate in newly diagnosed patients with diffuse large B cell lymphoma (DLBCL) aged more than 50 years without prior histories of clinical immunosuppression compared with healthy controls. Our results showed impaired EBV-specific immune responses among DLBCL patients that were associated primarily with decreased numbers of central and effector memory CD8+ T lymphocytes. In contrast to healthy controls, only a minority of the patients showed CD4+\/tumour necrosis factor (TNF)-\u03b1+ T cells expressing T cell receptor (TCR)-V\u03b217 and CD8+\/TNF-\u03b1+ T cells with TCR-V\u03b25\u00b72, V\u03b29 and V\u03b218 in response to EBV. Notably, the production of TNF-\u03b1 was undetectable among TCR-V\u03b25\u00b73+, V\u03b211+, V\u03b212+, V\u03b216+ and V\u03b223+ CD8+ T cells. In addition, we observed decreased numbers of CD4+\/TNF-\u03b1+ and CD8+\/TNF-\u03b1+, CD8+\/interleukin (IL)-2+ and CD8+\/TNF-\u03b1+\/IL-2+ T lymphocytes in the absence of T cells capable of producing TNF-\u03b1, IL-2 and IFN-\u03b3 after EBV stimulation simultaneously. Moreover, DLBCL patients displayed higher IL-10 levels both under baseline conditions and after EBV stimulation. These findings were also observed in patients with positive EBV viral loads. Prospective studies including a large number of patients are needed to confirm these findings.<\/jats:p>","DOI":"10.1111\/cei.12682","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T22:17:21Z","timestamp":1436912241000},"page":"173-183","source":"Crossref","is-referenced-by-count":26,"title":["Epstein\u2013Barr virus-specific CD8+ T lymphocytes from diffuse large B cell lymphoma patients are functionally impaired"],"prefix":"10.1093","volume":"182","author":[{"given":"D","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Grupo De Inmunobiolog\u00eda Y Biolog\u00eda Celular Departamento De Microbiolog\u00eda Facultad De Ciencias Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Grupo De Inmunobiolog\u00eda Y Biolog\u00eda Celular Departamento De Microbiolog\u00eda Facultad De Ciencias Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Orfao","sequence":"additional","affiliation":[{"name":"Servicio General De Citometr\u00eda Y Departamento De Medicina, Centro De Investigaci\u00f3n Del C\u00e1ncer (Instituto De Biolog\u00eda Molecular Y Celular Del C\u00e1ncer and IBSAL; CSIC-USAL), Universidad De Salamanca, Salamanca, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M V","family":"Herrera","sequence":"additional","affiliation":[{"name":"Servicio De Hematolog\u00eda Hospital Universitario San Ignacio-Centro De Oncolog\u00eda Javeriano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Solano","sequence":"additional","affiliation":[{"name":"Servicio De Hematolog\u00eda Hospital Universitario San Ignacio-Centro De Oncolog\u00eda Javeriano"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Olaya","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Uribe","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Pontificia Universidad Javeriana, Hospital Universitario San Ignacio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Grupo De Patolog\u00eda Fundaci\u00f3n Santa Fe De Bogot\u00e1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Duarte","sequence":"additional","affiliation":[{"name":"Servicio De Hematolog\u00eda Fundaci\u00f3n Santa Fe De Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio De Hematolog\u00eda Fundaci\u00f3n Santa Fe De Bogot\u00e1, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardiovascular De Colombia, Floridablanca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fiorentino","sequence":"additional","affiliation":[{"name":"Grupo De Inmunobiolog\u00eda Y Biolog\u00eda Celular Departamento De Microbiolog\u00eda Facultad De Ciencias Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Quijano","sequence":"additional","affiliation":[{"name":"Grupo De Inmunobiolog\u00eda Y Biolog\u00eda Celular Departamento De Microbiolog\u00eda Facultad De Ciencias Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"2021122010192477600_cei12682-bib-0001","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaci.2005.05.038","article-title":"EBV the prototypical human tumor virus \u2013 just how bad is it?","volume":"116","author":"Thorley-Lawson","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"2021122010192477600_cei12682-bib-0002","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2010.02.146","article-title":"Interaction of Epstein\u2013Barr virus (EBV) with human B-lymphocytes","volume":"396","author":"Klein","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"2021122010192477600_cei12682-bib-0003","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/PAP.0b013e3181916029","article-title":"Epstein\u2013Barr virus in lymphoproliferative processes: an update for the diagnostic pathologist","volume":"16","author":"Ng","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"2021122010192477600_cei12682-bib-0004","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ctrv.2010.02.011","article-title":"The contribution of the Epstein\u2013Barr virus to the pathogenesis of childhood lymphomas","volume":"36","author":"Cader","year":"2010","journal-title":"Cancer Treat Rev"},{"key":"2021122010192477600_cei12682-bib-0005","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nrmicro2015","article-title":"The curious case of the tumour virus: 50 years of Burkitt's lymphoma","volume":"6","author":"Thorley-Lawson","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"2021122010192477600_cei12682-bib-0006","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5045\/kjh.2012.47.2.92","article-title":"Epidemiologic overview of malignant lymphoma","volume":"47","author":"Huh","year":"2012","journal-title":"Korean J Hematol"},{"key":"2021122010192477600_cei12682-bib-0007","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1634\/theoncologist.2010-0213","article-title":"Epstein\u2013Barr virus positive diffuse large B-cell lymphoma of the elderly: what we know so far","volume":"16","author":"Castillo","year":"2011","journal-title":"Oncologist"},{"key":"2021122010192477600_cei12682-bib-0008","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pathol.1.110304.100209","article-title":"Spectrum of Epstein\u2013Barr virus-associated diseases","volume":"1","author":"Kutok","year":"2006","journal-title":"Annu Rev Pathol"},{"key":"2021122010192477600_cei12682-bib-0009","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.semcancer.2008.10.002","article-title":"Immune escape by Epstein\u2013Barr virus associated malignancies","volume":"18","author":"M\u00fcnz","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"2021122010192477600_cei12682-bib-0010","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.immunol.25.022106.141553","article-title":"Cellular responses to viral infection in humans: lessons from Epstein\u2013Barr virus","volume":"25","author":"Hislop","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"2021122010192477600_cei12682-bib-0011","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMra0807082","article-title":"Aggressive lymphomas","volume":"362","author":"Lenz","year":"2010","journal-title":"N Engl J Med"},{"key":"2021122010192477600_cei12682-bib-0012","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1182\/blood.V98.1.146","article-title":"Dysfunctional Epstein\u2013Barr virus (EBV)-specific CD8+ T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma","volume":"98","author":"van Baarle","year":"2001","journal-title":"Blood"},{"key":"2021122010192477600_cei12682-bib-0013","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1182\/blood-2005-01-0432","article-title":"Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma","volume":"106","author":"Piriou","year":"2005","journal-title":"Blood"},{"key":"2021122010192477600_cei12682-bib-0014","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/icb.2009.74","article-title":"Narrowing of T-cell receptor beta variable repertoire during symptomatic herpesvirus infection in transplant patients","volume":"88","author":"Wynn","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"2021122010192477600_cei12682-bib-0015","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2567.2011.03476.x","article-title":"Long-term carriers generate Epstein\u2013Barr virus (EBV)-specific CD4+ and CD8+ polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins","volume":"134","author":"Ning","year":"2011","journal-title":"Immunology"},{"key":"2021122010192477600_cei12682-bib-0016","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2353\/jmoldx.2008.080023","article-title":"Laboratory assays for Epstein\u2013Barr virus-related disease","volume":"10","author":"Gulley","year":"2008","journal-title":"J Mol Diagn"},{"key":"2021122010192477600_cei12682-bib-0017","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.hoc.2008.07.004","article-title":"Molecular biology and genetics of lymphomas","volume":"22","author":"Hartmann","year":"2008","journal-title":"Hematol Oncol Clin North Am"},{"key":"2021122010192477600_cei12682-bib-0018","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/PAP.0b013e3181a9d5d2","article-title":"Diffuse aggressive B-cell lymphomas","volume":"16","author":"Said","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"2021122010192477600_cei12682-bib-0019","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1365-2567.2008.03035.x","article-title":"Cytolytic mechanisms and T-cell receptor V\u03b2 usage by ex vivo generated Epstein\u2013Barr virus-specific cytotoxic T lymphocytes","volume":"127","author":"Vanhoutte","year":"2009","journal-title":"Immunology"},{"key":"2021122010192477600_cei12682-bib-0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/eji.200425548","article-title":"Contemporaneous fluctuations in T cell responses to persistent herpes virus infections","volume":"35","author":"Crough","year":"2005","journal-title":"Eur J Immunol"},{"key":"2021122010192477600_cei12682-bib-0021","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4049\/jimmunol.0803647","article-title":"Clonotype selection and composition of human CD8 T cells specific for persistent herpes viruses varies with differentiation but is stable over time","volume":"183","author":"Iancu","year":"2009","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0022","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.exger.2007.06.008","article-title":"The immune system in extreme longevity","volume":"43","author":"Sansoni","year":"2008","journal-title":"Exp Gerontol"},{"key":"2021122010192477600_cei12682-bib-0023","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/cei.12337","article-title":"Age-associated Epstein\u2013Barr virus-specific T cell responses in seropositive healthy adults","volume":"177","author":"C\u00e1rdenas Sierra","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"2021122010192477600_cei12682-bib-0024","first-page":"523","article-title":"The 2008 WHO classification of lymphomas: implications for clinical practice and translational research","volume":"2009","author":"Jaffe","year":"2009","journal-title":"ASH Education Program Book"},{"key":"2021122010192477600_cei12682-bib-0025","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-1759(00)00326-4","article-title":"Routine detection of Epstein\u2013Barr virus specific T-cells in the peripheral blood by flow cytometry","volume":"247","author":"Crucian","year":"2001","journal-title":"J Immunol Methods"},{"key":"2021122010192477600_cei12682-bib-0026","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/labinvest.3700162","article-title":"A new simple whole blood flow cytometry-based method for simultaneous identification of activated cells and quantitative evaluation of cytokines released during activation","volume":"84","author":"Rodr\u00edguez-Caballero","year":"2004","journal-title":"Lab Invest"},{"key":"2021122010192477600_cei12682-bib-0027","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.4049\/jimmunol.161.10.5284","article-title":"Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis","volume":"161","author":"Waldrop","year":"1998","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0028","first-page":"1","article-title":"Simultaneous detection of cell activation and quantitation of the secreted cytokynes","volume":"9","author":"Orfao","year":"2003","journal-title":"Curr Protoc Cytometry"},{"key":"2021122010192477600_cei12682-bib-0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1079-9796(03)00014-7","article-title":"Immunophenotype and TCR-V [beta] repertoire of peripheral blood T-cells in acute infectious mononucleosis","volume":"30","author":"Lima","year":"2003","journal-title":"Blood Cells Mol Dis"},{"key":"2021122010192477600_cei12682-bib-0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cyto.b.20187","article-title":"Association between the HLA haplotype and the TCR-V\u03b2 repertoire of anti-CMV specific memory T-cells in immunocompetent healthy adults","volume":"72","author":"Rodriguez-Caballero","year":"2007","journal-title":"Cytometry B Clin Cytom"},{"key":"2021122010192477600_cei12682-bib-0031","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/cncr.21746","article-title":"Characterization of bone marrow T cells in monoclonal gammopathy of undetermined significance, multiple myeloma, and plasma cell leukemia demonstrates increased infiltration by cytotoxic\/Th1 T cells demonstrating a squed TCR-V\u03b2 repertoire","volume":"106","author":"P\u00e9rez-Andres","year":"2006","journal-title":"Cancer"},{"key":"2021122010192477600_cei12682-bib-0032","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/eji.200940000","article-title":"Human peripheral blood and bone marrow Epstein\u2013Barr virus-specific T-cell repertoire in latent infection reveals distinct memory T-cell subsets","volume":"40","author":"Guerreiro","year":"2010","journal-title":"Eur J Immunol"},{"key":"2021122010192477600_cei12682-bib-0033","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/35005534","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"402","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"2021122010192477600_cei12682-bib-0034","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/1097-0320(20000801)40:4<336::AID-CYTO9>3.0.CO;2-0","article-title":"Flow cytometric analysis of the V\u03b2 repertoire in healthy controls","volume":"40","author":"van den Beemd","year":"2000","journal-title":"Cytometry"},{"key":"2021122010192477600_cei12682-bib-0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/464680","article-title":"Molecular profiling of aggressive lymphomas","volume":"2012","author":"Rossi","year":"2012","journal-title":"Adv Hematol"},{"key":"2021122010192477600_cei12682-bib-0036","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1521-6616(03)00043-3","article-title":"Identification of oligoclonal CD4 T cells in diffuse large B cell lymphomas","volume":"107","author":"Li","year":"2003","journal-title":"Clin Immunol"},{"key":"2021122010192477600_cei12682-bib-0037","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1179\/102453310X12583347009856","article-title":"Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma","volume":"15","author":"Tan","year":"2010","journal-title":"Hematology"},{"key":"2021122010192477600_cei12682-bib-0038","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1172\/JCI10590","article-title":"CD8+ T-cell selection, function, and death in the primary immune response in vivo","volume":"106","author":"Callan","year":"2000","journal-title":"J Clin Invest"},{"key":"2021122010192477600_cei12682-bib-0039","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.4049\/jimmunol.165.9.4831","article-title":"Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response","volume":"165","author":"Annels","year":"2000","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0040","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1084\/jem.184.5.1815","article-title":"Development of Epstein\u2013Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis","volume":"184","author":"Silins","year":"1996","journal-title":"J Exp Med"},{"key":"2021122010192477600_cei12682-bib-0041","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4382::AID-IMMU4382>3.0.CO;2-Z","article-title":"T cell selection during the evolution of CD 8+ T cell memory in vivo","volume":"28","author":"Callan","year":"1998","journal-title":"Eur J Immunol"},{"key":"2021122010192477600_cei12682-bib-0042","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.4049\/jimmunol.167.4.2019","article-title":"EBV-specific CD8+ T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function","volume":"167","author":"Hislop","year":"2001","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0043","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1084\/jem.20092532","article-title":"IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform","volume":"207","author":"Darrah","year":"2010","journal-title":"J Exp Med"},{"key":"2021122010192477600_cei12682-bib-0044","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cell.2009.06.036","article-title":"Redefining chronic viral infection","volume":"138","author":"Virgin","year":"2009","journal-title":"Cell"},{"key":"2021122010192477600_cei12682-bib-0045","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1189\/jlb.0611271","article-title":"Tregs and infections: on the potential value of modifying their function","volume":"90","author":"Sehrawat","year":"2011","journal-title":"J Leukoc Biol"},{"key":"2021122010192477600_cei12682-bib-0046","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.4049\/jimmunol.170.12.6183","article-title":"Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1","volume":"170","author":"Marshall","year":"2003","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0047","doi-asserted-by":"publisher","first-page":"ii","DOI":"10.1016\/j.semcancer.2015.04.006","article-title":"Cross-talk between Epstein\u2013Barr virus and microenvironment in the pathogenesis of lymphomas","author":"Dolcetti","year":"2015","journal-title":"Semin Cancer Biol"},{"key":"2021122010192477600_cei12682-bib-0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/564296","article-title":"Control of the inflammatory response mechanisms mediated by natural and induced regulatory T-cells in HCV-, HTLV-1-, and EBV-associated cancers","volume":"2014","author":"Ouaguia","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2021122010192477600_cei12682-bib-0049","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nri2496","article-title":"Migration, maintenance and recall of memory T cells in peripheral tissues","volume":"9","author":"Woodland","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"2021122010192477600_cei12682-bib-0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"Tcell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"2021122010192477600_cei12682-bib-0051","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12026-012-8289-3","article-title":"The immune system in the aging human","volume":"53","author":"Rymkiewicz","year":"2012","journal-title":"Immunol Res"},{"key":"2021122010192477600_cei12682-bib-0052","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.4049\/jimmunol.1201867","article-title":"Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life","volume":"189","author":"Smithey","year":"2012","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0053","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4049\/jimmunol.174.2.1037","article-title":"Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence","volume":"174","author":"Harari","year":"2005","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0054","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1002\/eji.200425324","article-title":"Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load","volume":"34","author":"Harari","year":"2004","journal-title":"Eur J Immunol"},{"key":"2021122010192477600_cei12682-bib-0055","first-page":"209","article-title":"Polyfunctional analysis of human T cell responses: importance in vaccine immunogenicity and natural infection. Semin","volume":"28","author":"Makedonas","year":"2006","journal-title":"Immunopathol"},{"key":"2021122010192477600_cei12682-bib-0056","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/cyto.a.20643","article-title":"Phenotype and function of human T lymphocyte subsets: consensus and issues","volume":"73","author":"Appay","year":"2008","journal-title":"Cytometry A"},{"key":"2021122010192477600_cei12682-bib-0057","doi-asserted-by":"crossref","first-page":"5854","DOI":"10.4049\/jimmunol.1001024","article-title":"EBV-specific CD8+ T cells from asymptomatic pediatric thoracic transplant patients carrying chronic high EBV loads display contrasting features: activated phenotype and exhausted function","volume":"186","author":"Macedo","year":"2011","journal-title":"J Immunol"},{"key":"2021122010192477600_cei12682-bib-0058","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1600-6143.2007.02080.x","article-title":"Chronic high Epstein\u2013Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease\/lymphoma in children","volume":"8","author":"Bingler","year":"2008","journal-title":"Am J Transplant"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12682","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/182\/2\/173\/41792339\/cei12682.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/182\/2\/173\/41792339\/cei12682.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T06:36:01Z","timestamp":1691822161000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/182\/2\/173\/6422090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,11]]},"references-count":58,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,9,11]]},"published-print":{"date-parts":[[2015,10,13]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12682","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,11]]},"published":{"date-parts":[[2015,9,11]]}}}