{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:50:12Z","timestamp":1790682612952,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T00:00:00Z","timestamp":1442275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,10,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sj\u00f6gren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this disease. We obtained salivary samples from 12 female pSS patients (mean age 44.2 \u00b1 13.01) and 21 age-matched female HCs. The metabolite profiles of saliva were analysed by gas chromatography-mass spectrometry. The total metabolite levels in each of the samples were calculated and compared across the study participants. A total of 88 metabolites were detected across the study samples, 41 of which were observed at reduced levels in the samples frompSS patients. Principal component analysis (PCA) revealed a loss in salivary metabolite diversity in the pSS patient samples compared to the HC samples. The reduced presence of glycine, tyrosine, uric acid and fucose, which may reflect salivary gland destruction due to chronic sialoadenitis, contributed to the loss of diversity. Comparative PCA of the pSS patients revealed the presence of two subpopulations based on their metabolite profiles, and these two subpopulations showed a significant difference in the prevalence of major salivary glanditis (P = 0\u00b7014). In this study, we found that the salivary metabolite profile of pSS patients was less diverse than that of HCs and that the metabolite profiles in pSS patients were affected by the presence of major salivary glanditis.<\/jats:p>","DOI":"10.1111\/cei.12683","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T16:06:56Z","timestamp":1437494816000},"page":"149-153","source":"Crossref","is-referenced-by-count":78,"title":["Metabolomics analysis of saliva from patients with primary Sj\u00f6gren's syndrome"],"prefix":"10.1093","volume":"182","author":[{"given":"G","family":"Kageyama","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Saegusa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Irino","sequence":"additional","affiliation":[{"name":"Division of Evidence-Based Laboratory Medicine, Graduate School of Medicine, Kobe University, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sendo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Morinobu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kobe University Hospital, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,15]]},"reference":[{"key":"2021122010192685900_cei12683-bib-0001","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s12010-012-9891-5","article-title":"Saliva metabolomics opens door to biomarker discovery, disease diagnosis, and treatment","volume":"168","author":"Zhang","year":"2012","journal-title":"Appl Biochem Biotechnol"},{"key":"2021122010192685900_cei12683-bib-0002","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1093\/rheumatology\/kei212","article-title":"Identification of parotid salivary biomarkers in Sjogren's syndrome by surface-enhanced laser desorption\/ionization time-of-flight mass 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