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Following antigen encounter, B cells are activated, proliferate rapidly and undergo two diversification events; somatic hypermutation (followed by selection), which enhances the affinity of the antibody for its cognate antigen, and class-switch recombination, which alters the effector functions of the antibody to adapt the response to the challenge faced. B cells must then differentiate into antibody-secreting plasma cells or long-lived memory B cells. These activities take place in specialized immunological environments called germinal centres, usually located in the secondary lymphoid organs. To complete the germinal centre activities successfully, a B cell adopts a transcriptional programme that allows it to migrate to specific sites within the germinal centre, proliferate, modify its DNA recombination and repair pathways, alter its apoptotic potential and finally undergo terminal differentiation. To co-ordinate these processes, B cells employ a number of \u2018master regulator\u2019 transcription factors which mediate wholesale transcriptomic changes. These master transcription factors are mutually antagonistic and form a complex regulatory network to maintain distinct gene expression programs. Within this network, multiple points of positive and negative feedback ensure the expression of the \u2018master regulators\u2019, augmented by a number of \u2018secondary\u2019 factors that reinforce these networks and sense the progress of the immune response. In this review we will discuss the different activities B cells must undertake to mount a successful T cell-dependent immune response and describe how a regulatory network of transcription factors controls these processes.<\/jats:p>","DOI":"10.1111\/cei.12702","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T19:34:50Z","timestamp":1441827290000},"page":"65-75","source":"Crossref","is-referenced-by-count":54,"title":["Transcription factors regulating B cell fate in the germinal centre"],"prefix":"10.1093","volume":"183","author":[{"given":"T","family":"Recaldin","sequence":"first","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Fear","sequence":"additional","affiliation":[{"name":"Division of Asthma, Allergy and Lung Biology, Medical 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