{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:26:39Z","timestamp":1784809599862,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":2197,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CB-2008-01 100708"],"award-info":[{"award-number":["CB-2008-01 100708"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["CB-2011-01 167278"],"award-info":[{"award-number":["CB-2011-01 167278"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DGAPA","award":["IN213911"],"award-info":[{"award-number":["IN213911"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. It is considered that, during co-evolution, the parasite developed strategies to modulate the host\u2019s immune response. The action mechanisms of regulatory T cells in controlling the immune response in neurocysticercosis are studied in this work. Higher blood levels of regulatory T cells with CD4+CD45RO+forkhead box protein 3 (FoxP3)high and CD4+CD25highFoxP3+CD95high phenotype and of non-regulatory CD4+CD45RO+FoxP3med T cells were found in neurocysticercosis patients with respect to controls. Interestingly, regulatory T cells express higher levels of cytotoxic T lymphocyte antigen 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), programmed death 1 (PD-1) and glucocorticoid-induced tumour necrosis factor receptor (GITR), suggesting a cell-to-cell contact mechanism with dendritic cells. Furthermore, higher IL-10 and regulatory T cell type 1 (Tr1) levels were found in neurocysticercosis patients\u2019 peripheral blood, suggesting that the action mechanism of regulatory T cells involves the release of immunomodulatory cytokines. No evidence was found of the regulatory T cell role in inhibiting the proliferative response. Suppressive regulatory T cells from neurocysticercosis patients correlated negatively with late activated lymphocytes (CD4+CD38+). Our results suggest that, during neurocysticercosis, regulatory T cells could control the immune response, probably by a cell-to-cell contact with dendritic cells and interleukin (IL)-10 release by Tr1, to create an immunomodulatory environment that may favour the development of T. solium cysticerci and their permanence in the central nervous system.<\/jats:p>","DOI":"10.1111\/cei.12709","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T08:16:31Z","timestamp":1442909791000},"page":"271-279","source":"Crossref","is-referenced-by-count":37,"title":["Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis"],"prefix":"10.1093","volume":"183","author":[{"given":"A","family":"Arce-Sillas","sequence":"first","affiliation":[{"name":"Unidad Perif\u00e9rica para el Estudio de Neuroinflamaci\u00f3n del Instituto de Investigaciones Biom\u00e9dicas de la UNAM en el Instituto Nacional de 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M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Casanova-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Unidad Perif\u00e9rica para el Estudio de Neuroinflamaci\u00f3n del Instituto de Investigaciones Biom\u00e9dicas de la UNAM en el Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, M\u00e9xico"},{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J V","family":"Proa\u00f1o Narv\u00e1ez","sequence":"additional","affiliation":[{"name":"Unidad M\u00e9dica de Enfermedades Neurol\u00f3gicas, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Garc\u00eda-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda Molecular, Departamento de Anatom\u00eda Patol\u00f3gica, Instituto Nacional de Pediatr\u00eda, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fleury","sequence":"additional","affiliation":[{"name":"Unidad Perif\u00e9rica para el Estudio de Neuroinflamaci\u00f3n del Instituto de Investigaciones Biom\u00e9dicas de la UNAM en el Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, M\u00e9xico"},{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda, 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