{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:50:16Z","timestamp":1770472216073,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":2170,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In this work, we aimed to evaluate the levels of ferritin enriched in H subunits (H-ferritin) and ferritin enriched in L subunits (L-ferritin) and the cells expressing these two molecules in the lymph node (LN) biopsies obtained from adult-onset Still's disease (AOSD) patients, and the possible correlation among these data and the severity of the disease. Ten patients with AOSD underwent LN biopsy. All the samples were stained by immunofluorescence. A statistical analysis was performed to estimate the possible correlation among both H-ferritin and L-ferritin tissue expression and the clinical picture of the disease. Furthermore, the same analysis was performed to evaluate the possible correlation among the number of CD68+\/H-ferritin+ or CD68+\/L-ferritin+ cells and the clinical picture. Immunofluorescence analysis demonstrated an increased tissue H-ferritin expression in the LNs of AOSD patients. This increased expression correlated with the severity of the disease. An increased number of CD68 macrophages expressing H-ferritin was observed in the LN samples of our patients. Furthermore, we observed that the number of CD68+\/H-ferritin+ cells correlated significantly with the severity of the clinical picture. Our data showed an imbalance between the levels of H- and L-ferritin in LNs of AOSD patients and the evidence of an increased number of CD68+\/H-ferritin+ cells in the same organs. Furthermore, a correlation among both the tissue H-ferritin levels and the CD68+\/H-ferritin+ cells and the clinical picture was observed.<\/jats:p>","DOI":"10.1111\/cei.12738","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T23:06:43Z","timestamp":1446764803000},"page":"397-404","source":"Crossref","is-referenced-by-count":29,"title":["The CD68+\/H-ferritin+ cells colonize the lymph nodes of the patients with adult onset Still's disease and are associated with increased extracellular level of H-ferritin in the same tissue: correlation with disease severity and implication for pathogenesis"],"prefix":"10.1093","volume":"183","author":[{"given":"P","family":"Ruscitti","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Ciccia","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Guggino","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Di Benedetto","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rizzo","sequence":"additional","affiliation":[{"name":"General Pathology, Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Liakouli","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Berardicurti","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Carubbi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Triolo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, University of Palermo, Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,8]]},"reference":[{"key":"2021111804091299400_cei12738-bib-0001","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.autrev.2014.08.032","article-title":"Adult onset Still's disease (AOSD) in the era of biologic therapies: dichotomous view for cytokine and clinical expressions","volume":"13","author":"Maria","year":"2014","journal-title":"Autoimmun Rev"},{"key":"2021111804091299400_cei12738-bib-0002","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10067-013-2381-5","article-title":"Tocilizumab for the treatment of adult-onset Still's disease: results from a case series","volume":"33","author":"Cipriani","year":"2014","journal-title":"Clin Rheumatol"},{"key":"2021111804091299400_cei12738-bib-0003","first-page":"28","article-title":"Clinical features and prognosis in 82 patients with adult-onset Still's disease","volume":"32","author":"Kim","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"2021111804091299400_cei12738-bib-0004","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.1097\/MD.0000000000000787","article-title":"The pathologic findings of skin, lymph node, liver, and bone marrow in patients with adult-onset still disease: a comprehensive analysis of 40 cases","volume":"94","author":"Kim","year":"2015","journal-title":"Medicine (Balt)"},{"key":"2021111804091299400_cei12738-bib-0005","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/1741-7015-11-185","article-title":"The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome","volume":"11","author":"Ros\u00e1rio","year":"2013","journal-title":"BMC Med"},{"key":"2021111804091299400_cei12738-bib-0006","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/PCC.0b013e3181a1ae08","article-title":"Secondary hemophagocytic lymphohistiocytosis and severe sepsis\/systemic inflammatory response syndrome\/multiorgan dysfunction syndrome\/macrophage activation syndrome share common intermediate phenotypes on a spectrum of inflammation","volume":"10","author":"Castillo","year":"2009","journal-title":"Pediatr Crit Care Med"},{"key":"2021111804091299400_cei12738-bib-0007","first-page":"187","article-title":"Hemophagocytic syndrome with hyperferritinemia: a stormy immunological response","volume":"15","author":"Zandman-Goddard","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"2021111804091299400_cei12738-bib-0008","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","article-title":"Serum ferritin: past, present and future","volume":"1800","author":"Wang","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"2021111804091299400_cei12738-bib-0009","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"key":"2021111804091299400_cei12738-bib-0010","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2009-11-253815","article-title":"Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway","volume":"116","author":"Cohen","year":"2010","journal-title":"Blood"},{"key":"2021111804091299400_cei12738-bib-0011","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jaut.2007.11.003","article-title":"New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity","volume":"30","author":"Recalcati","year":"2008","journal-title":"J Autoimmun"},{"key":"2021111804091299400_cei12738-bib-0012","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1002\/1097-0142(19890615)63:12<2492::AID-CNCR2820631222>3.0.CO;2-7","article-title":"Effects of isoferritins on human granulocytes","volume":"63","author":"Hann","year":"1989","journal-title":"Cancer"},{"key":"2021111804091299400_cei12738-bib-0013","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood.V83.3.737.737","article-title":"H and L-rich ferritins suppress antibody production, but not proliferation, of human B lymphocytes in vitro","volume":"83","author":"Morikawa","year":"1994","journal-title":"Blood"},{"key":"2021111804091299400_cei12738-bib-0014","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1084\/jem.153.6.1426","article-title":"Identification of leukemia-associated inhibitory activity as acidic isoferritins. A regulatory role for acidic isoferritins in the production of granulocytes and macrophages","volume":"153","author":"Broxmeyer","year":"1981","journal-title":"J Exp Med"},{"key":"2021111804091299400_cei12738-bib-0015","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ijc.1269","article-title":"Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production","volume":"92","author":"Gray","year":"2001","journal-title":"Int J Cancer"},{"key":"2021111804091299400_cei12738-bib-0016","doi-asserted-by":"crossref","first-page":"37616","DOI":"10.1074\/jbc.M607266200","article-title":"Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain","volume":"281","author":"Li","year":"2006","journal-title":"J Biol Chem"},{"key":"2021111804091299400_cei12738-bib-0017","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/hep.22716","article-title":"Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta\/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells","volume":"49","author":"Ruddell","year":"2009","journal-title":"Hepatology"},{"key":"2021111804091299400_cei12738-bib-0018","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1084\/jem.20042433","article-title":"TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis","volume":"202","author":"Chen","year":"2005","journal-title":"J Exp Med"},{"key":"2021111804091299400_cei12738-bib-0019","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri1111","article-title":"The TIM gene family: emerging roles in immunity and disease","volume":"3","author":"Kuchroo","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"2021111804091299400_cei12738-bib-0020","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20050308","article-title":"Tim-2 regulates T helper type 2 responses and autoimmunity","volume":"202","author":"Chakravarti","year":"2005","journal-title":"J Exp Med"},{"key":"2021111804091299400_cei12738-bib-0021","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.4049\/jimmunol.177.8.4966","article-title":"Cutting edge: inhibition of T cell activation by TIM-2","volume":"177","author":"Knickelbein","year":"2006","journal-title":"J Immunol"},{"key":"2021111804091299400_cei12738-bib-0022","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2172-12-30","article-title":"Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor","volume":"12","author":"Smith","year":"2011","journal-title":"BMC Immunol"},{"key":"2021111804091299400_cei12738-bib-0023","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-065X.2009.00772.x","article-title":"The costimulatory role of TIM molecules","volume":"229","author":"Rodriguez-Manzanet","year":"2009","journal-title":"Immunol Rev"},{"key":"2021111804091299400_cei12738-bib-0024","doi-asserted-by":"crossref","first-page":"a016378","DOI":"10.1101\/cshperspect.a016378","article-title":"Sinusoidal immunity: macrophages at the lymphohematopoietic interface","volume":"7","author":"Gordon","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2021111804091299400_cei12738-bib-0025","first-page":"424","article-title":"Preliminary criteria for classification of adult Still's disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"2021111804091299400_cei12738-bib-0026","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780300209","article-title":"Adult-onset Still's disease. Clinical course and outcome","volume":"30","author":"Cush","year":"1987","journal-title":"Arthritis Rheum"},{"key":"2021111804091299400_cei12738-bib-0027","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00005792-199103000-00004","article-title":"Adult Still's disease: manifestations, disease course, and outcome in 62 patients","volume":"70","author":"Pouchot","year":"1991","journal-title":"Medicine (Balt)"},{"key":"2021111804091299400_cei12738-bib-0028","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/jcp.2004.018010","article-title":"Spectrum of lymph node pathology in adult onset Still's disease; analysis of 12 patients with one follow up biopsy","volume":"57","author":"Jeon","year":"2004","journal-title":"J Clin Pathol"},{"key":"2021111804091299400_cei12738-bib-0029","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/S0140-6736(13)61048-X","article-title":"Adult haemophagocytic syndrome","volume":"383","author":"Ramos-Casals","year":"2014","journal-title":"Lancet"},{"key":"2021111804091299400_cei12738-bib-0030","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.blre.2008.08.001","article-title":"Ferritin for the clinician","volume":"23","author":"Knovich","year":"2009","journal-title":"Blood Rev"},{"key":"2021111804091299400_cei12738-bib-0031","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev-immunol-032414-112220","article-title":"Macrophages: development and tissue specialization","volume":"33","author":"Varol","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2021111804091299400_cei12738-bib-0032","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"2021111804091299400_cei12738-bib-0033","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"2021111804091299400_cei12738-bib-0034","first-page":"L257","article-title":"Effects of TNF-alpha and IL-1beta on iron metabolism by A549 cells and influence on cytotoxicity","volume":"277","author":"Smirnov","year":"1999","journal-title":"Am J Physiol"},{"key":"2021111804091299400_cei12738-bib-0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0006-291X(90)91466-6","article-title":"Interleukin 1 induces ferritin heavy chain in human muscle cells","volume":"169","author":"Wei","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"2021111804091299400_cei12738-bib-0036","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0167-4889(00)00066-5","article-title":"Interleukin-1beta increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool","volume":"1497","author":"Pi\u00f1ero","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"2021111804091299400_cei12738-bib-0037","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ni.2060","article-title":"Inflammation meets cancer, with NF-\u03baB as the matchmaker","volume":"12","author":"Ben-Neriah","year":"2011","journal-title":"Nat Immunol"},{"key":"2021111804091299400_cei12738-bib-0038","first-page":"2189","article-title":"Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease","volume":"31","author":"Chen","year":"2004","journal-title":"J Rheumatol"},{"key":"2021111804091299400_cei12738-bib-0039","doi-asserted-by":"crossref","first-page":"e82874","DOI":"10.1371\/journal.pone.0082874","article-title":"Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2","volume":"8","author":"Silva-Gomes","year":"2013","journal-title":"PLOS ONE"},{"key":"2021111804091299400_cei12738-bib-0040","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.autrev.2007.01.016","article-title":"Ferritin in autoimmune diseases","volume":"6","author":"Zandman-Goddard","year":"2007","journal-title":"Autoimmun Rev"},{"key":"2021111804091299400_cei12738-bib-0041","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12026-014-8563-7","article-title":"sCD163 in AOSD: a biomarker for macrophage activation related to hyperferritinemia","volume":"60","author":"Colafrancesco","year":"2014","journal-title":"Immunol Res"},{"key":"2021111804091299400_cei12738-bib-0042","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1136\/annrheumdis-2012-202963","article-title":"Contribution of antiferritin antibodies to diagnosis of giant cell arteritis","volume":"72","author":"R\u00e9gent","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2021111804091299400_cei12738-bib-0043","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1136\/annrheumdis-2011-200413","article-title":"Association of ferritin autoantibodies with giant cell arteritis\/polymyalgia rheumatica","volume":"71","author":"Baerlecken","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"2021111804091299400_cei12738-bib-0044","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/rheumatology\/38.5.477","article-title":"High serum level of macrophage-colony stimulating factor (M-CSF) in adult-onset Still's disease","volume":"38","author":"Matsui","year":"1999","journal-title":"Rheumatology (Oxf)"},{"key":"2021111804091299400_cei12738-bib-0045","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3899\/jrheum.091120","article-title":"Serum calprotectin as a marker for disease activity and severity in adult-onset Still's disease","volume":"37","author":"Jung","year":"2010","journal-title":"J Rheumatol"},{"key":"2021111804091299400_cei12738-bib-0046","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.clinbiochem.2008.01.008","article-title":"The levels of macrophage migration inhibitory factor as an indicator of disease activity and severity in adult-onset Still's disease","volume":"41","author":"Zou","year":"2008","journal-title":"Clin Biochem"},{"key":"2021111804091299400_cei12738-bib-0047","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.clim.2012.05.004","article-title":"Lymph node vascular-stromal growth and function as a potential target for controlling immunity","volume":"144","author":"Benahmed","year":"2012","journal-title":"Clin Immunol"},{"key":"2021111804091299400_cei12738-bib-0048","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/imr.12023","article-title":"Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity","volume":"251","author":"Malhotra","year":"2013","journal-title":"Immunol Rev"},{"key":"2021111804091299400_cei12738-bib-0049","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MD.0000000000000021","article-title":"Adult onset Still's disease: manifestations, treatments, outcome, and prognostic factors in 57 patients","volume":"93","author":"Gerfaud-Valentin","year":"2014","journal-title":"Medicine (Balt)"},{"key":"2021111804091299400_cei12738-bib-0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.autrev.2015.01.004","article-title":"Increased level of H-ferritin and its imbalance with L-ferritin, in bone marrow and liver of patients with adult onset Still's disease, developing macrophage activation syndrome, correlate with the severity of the disease","volume":"14","author":"Ruscitti","year":"2015","journal-title":"Autoimmun Rev"},{"key":"2021111804091299400_cei12738-bib-0051","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.autrev.2014.01.058","article-title":"Adult-onset Still's disease","volume":"13","author":"Gerfaud-Valentin","year":"2014","journal-title":"Autoimmun Rev"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12738","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/183\/3\/397\/41125927\/cei12738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/183\/3\/397\/41125927\/cei12738.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:26:54Z","timestamp":1641054414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/183\/3\/397\/6412195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,8]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,12,8]]},"published-print":{"date-parts":[[2016,2,11]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12738","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,3]]},"published":{"date-parts":[[2015,12,8]]}}}