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Here we report an efficacy test of FR104, a new co-stimulation inhibitor directly targeting CD28 on T cells, in a translationally relevant model, the rhesus monkey model of collagen-induced arthritis (CIA). As a relevant comparator we used abatacept [cytotoxic T lymphocyte antigen immunoglobulin (CTLA Ig)], an antagonist of CTLA-4 binding to CD80\/86 clinically approved for treatment of RA. Treatment with either compound was started at the day of CIA induction. Although FR104 previously demonstrated a higher control of T cell responses in vitro than abatacept, both compounds were equally potent in the suppression of CIA symptoms and biomarkers, such as the production of C-reactive protein (CRP) and interleukin (IL)-6 and anti-collagen type II (CII) serum antibody (IgM\/IgG). However, in contrast to abatacept, FR104 showed effective suppression of CII-induced peripheral blood mononuclear cell (PBMC) proliferation. The current study demonstrates a strong potential of the new selective CD28 antagonist FR104 for treatment of RA.<\/jats:p>","DOI":"10.1111\/cei.12739","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T18:06:43Z","timestamp":1446746803000},"page":"405-418","source":"Crossref","is-referenced-by-count":26,"title":["Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a non-human primate model of collagen-induced arthritis"],"prefix":"10.1093","volume":"183","author":[{"given":"M P M","family":"Vierboom","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Breedveld","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y S","family":"Kap","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Mary","sequence":"additional","affiliation":[{"name":"Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dicale, Universit\u00e9 De Nantes, Effimune SA, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Poirier","sequence":"additional","affiliation":[{"name":"Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dicale, Universit\u00e9 De Nantes, Effimune SA, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"'t Hart","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, the Netherlands"},{"name":"Department Neuroscience, University of Groningen, University Medical Center, Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Vanhove","sequence":"additional","affiliation":[{"name":"Institut National De La Sant\u00e9 Et De La Recherche M\u00e9dicale, Universit\u00e9 De Nantes, Effimune SA, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"2021111804091280600_cei12739-bib-0001","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/art.1780190307","article-title":"Predominance of T cells in the lymphocytic infiltrates of synovial tissues in rheumatoid arthritis","volume":"19","author":"Bankhurst","year":"1976","journal-title":"Arthritis Rheum"},{"key":"2021111804091280600_cei12739-bib-0002","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/art.20278","article-title":"Toward a better understanding of methotrexate","volume":"50","author":"Kremer","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2021111804091280600_cei12739-bib-0003","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2249.1993.tb08179.x","article-title":"The anti-arthritic and immunosuppressive effects of cyclosporin A on collagen-induced arthritis in the rhesus monkey","volume":"93","author":"Bakker","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"2021111804091280600_cei12739-bib-0004","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/art.1780370506","article-title":"A randomized, double-blind, 24-week controlled study of low-dose cyclosporine versus chloroquine for early rheumatoid arthritis","volume":"37","author":"Landewe","year":"1994","journal-title":"Arthritis Rheum"},{"key":"2021111804091280600_cei12739-bib-0005","first-page":"1984","article-title":"Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate","volume":"44","author":"Cohen","year":"2001","journal-title":"Utilization of leflunomide in the Treatment of Rheumatoid Arthritis Trial Investigator Group. 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