{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:40:07Z","timestamp":1718192407899},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":2136,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Scientific Research Fund of the Ministry of Education, Science and Culture, Japan.","award":["21659300","20249058"],"award-info":[{"award-number":["21659300","20249058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Our previous work revealed that the recipients with the highest pre-existing numbers of CD8+ effector T cells (TE) [hyperparathyroidism (HPT)E recipients] occupied approximately 30% of adult transplant recipients performed in our hospital. HPTE recipients demonstrated very poor clinical outcome compared with the remaining 70% of recipients with the lowest pre-existing TE (LPTE recipient). This study aimed to clarify the best combined immunosuppressive regimen related to function of cytotoxic T lymphocytes (CTLs) for HPTE recipients. Eighty-one HPTE recipients were classified into three types, according to the immunosuppressive regimens: type 1, tacrolimus (Tac)\/glucocorticoid (GC); type 2, Tac\/mycophenolate mofetil (MMF)\/GC; and type 3, Tac\/MMF. Frequencies of severe infection, rejection and hospital death were the highest in types 1 and 2, whereas the lowest occurred in type 3. The survival rate in type 3 was the highest (100%) during follow-up until post-operative day 2000. Regarding the immunological mechanism, in type 1 TE perforin and interferon (IFN)-\u03b3 were generated through the self-renewal of CD8+ central memory T cells (TCM), but decreased in the early post-transplant period due to marked down-regulation of interleukin (IL)-12 receptor beta-1 of TCM. In type 2, the self-renewal TCM did not develop, and the effector function could not be increased. In type 3, in contrast, the effectors and cytotoxicity were correlated inversely with IL-12R\u03b21+ TCM levels, and increased at the highest level around the pre-transplant levels of IL-12R\u03b21+ TCM. However, the immunological advantage of Tac\/MMF therapy was inhibited strongly by additive steroid administration.<\/jats:p>","DOI":"10.1111\/cei.12740","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T15:06:44Z","timestamp":1447254404000},"page":"126-136","source":"Crossref","is-referenced-by-count":2,"title":["Advantage of tacrolimus\/mycophenolate mofetil regimen for cytotoxic T cell-mediated defence and its inhibition by additive steroid administration in high-risk liver transplant recipients"],"prefix":"10.1093","volume":"184","author":[{"given":"S","family":"Uemoto","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Hepatic Disease Research Institute, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kaido","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine, Kyoto University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,1,11]]},"reference":[{"key":"2021111804092170700_cei12740-bib-0001","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/lt.20705","article-title":"Classification of human liver transplant recipients by their preoperative CD8+ T cell subpopulation and its relation to outcome","volume":"12","author":"Tanaka","year":"2006","journal-title":"Liver Transpl"},{"key":"2021111804092170700_cei12740-bib-0002","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.trsl.2010.06.002","article-title":"Initial burst of viremia related to CD8 effector memory T cells after living donor liver transplantation in hepatitis C virus-infected recipients","volume":"156","author":"Takada","year":"2010","journal-title":"Transl Res"},{"key":"2021111804092170700_cei12740-bib-0003","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/cei.12588","article-title":"Early coupled upregulation of IL-12 receptor beta-1 in CD8+ central memory and effector T cells for better clinical outcomes in liver transplant recipients","volume":"181","author":"Uemoto","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"2021111804092170700_cei12740-bib-0004","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0105-2896.2006.00382.x","article-title":"Signals required for programming effector and memory development by CD8+ T cells","volume":"211","author":"Mescher","year":"2006","journal-title":"Immunol Rev"},{"key":"2021111804092170700_cei12740-bib-0005","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.coi.2004.07.007","article-title":"Heterologous immunity and homeostatic proliferation as barriers to tolerance","volume":"16","author":"Taylor","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"2021111804092170700_cei12740-bib-0006","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"2021111804092170700_cei12740-bib-0007","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1074-7613(00)00032-7","article-title":"Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential","volume":"13","author":"Gunzer","year":"2000","journal-title":"Immunity"},{"key":"2021111804092170700_cei12740-bib-0008","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1126\/science.1071065","article-title":"Dynamic imaging of T cell\u2013dendritic cell interactions in lymph nodes","volume":"296","author":"Stoll","year":"2002","journal-title":"Science"},{"key":"2021111804092170700_cei12740-bib-0009","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/lt.20406","article-title":"Basic concepts in transplant immunology","volume":"11","author":"Martinez","year":"2005","journal-title":"Liver Transpl"},{"key":"2021111804092170700_cei12740-bib-0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2567.2009.03072.x","article-title":"Switch from perforin-expressing to perforin-deficient CD8(+) T cells accounts for two distinct types of effector cytotoxic T lymphocytes in vivo","volume":"128","author":"Meiraz","year":"2009","journal-title":"Immunology"},{"key":"2021111804092170700_cei12740-bib-0011","doi-asserted-by":"crossref","first-page":"19454","DOI":"10.1073\/pnas.0609706104","article-title":"CD27 mediates interleukin-2-independent clonal expansion of the CD8+ T cell without effector differentiation","volume":"103","author":"Carr","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021111804092170700_cei12740-bib-0012","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.0105-2896.2006.00390.x","article-title":"The rationale for the IL-2-independent generation of the self-renewing central memory CD8+ T cells","volume":"211","author":"Fearon","year":"2006","journal-title":"Immunol Rev"},{"key":"2021111804092170700_cei12740-bib-0013","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.20021910","article-title":"Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function","volume":"197","author":"Curtsinger","year":"2003","journal-title":"J Exp Med"},{"key":"2021111804092170700_cei12740-bib-0014","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells","volume":"162","author":"Curtsinger","year":"1999","journal-title":"J Immunol"},{"key":"2021111804092170700_cei12740-bib-0015","doi-asserted-by":"crossref","first-page":"6842","DOI":"10.4049\/jimmunol.169.12.6842","article-title":"The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells","volume":"169","author":"Valenzuela","year":"2002","journal-title":"J Immunol"},{"key":"2021111804092170700_cei12740-bib-0016","article-title":"Living-donor liver transplantation. Surgical techniques and innovation","author":"Tanaka","year":"2003","journal-title":"Barcelona, Spain: Prous Science"},{"key":"2021111804092170700_cei12740-bib-0017","first-page":"55","article-title":"Hierarchical clustering","volume-title":"Cluster analysis","author":"Everitt","year":"2001","edition":"4th"},{"key":"2021111804092170700_cei12740-bib-0018","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1002\/lt.21232","article-title":"Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans","volume":"13","author":"Egawa","year":"2007","journal-title":"Liver Transpl"},{"key":"2021111804092170700_cei12740-bib-0019","first-page":"285","article-title":"Therapeutic strategy and the role of apheresis therapy for ABO incompatible living donor liver transplantation. Ther Apher","volume":"9","author":"Kozaki","year":"2005","journal-title":"Dial"},{"key":"2021111804092170700_cei12740-bib-0020","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1365-2249.2010.04117.x","article-title":"Coupled regulation of interleukin-12 receptor beta-1 of CD8+ central memory and CCR7-negative memory T cells in early alloimmunity in liver transplant recipients","volume":"160","author":"Egawa","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"2021111804092170700_cei12740-bib-0021","first-page":"718386","article-title":"Serial assessment of immune status by circulating CD8+ effector T cell frequencies for posttransplant infectious complications","author":"Uemoto","year":"2008","journal-title":"Clin Dev Immunol"},{"key":"2021111804092170700_cei12740-bib-0022","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1155\/2001\/743019","article-title":"Liver transplantation: evolving patient selection criteria","volume":"15","author":"Yu","year":"2001","journal-title":"Can J Gastroenterol"},{"key":"2021111804092170700_cei12740-bib-0023","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/lt.21065","article-title":"Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients","volume":"13","author":"Tanaka","year":"2007","journal-title":"Liver Transpl"},{"key":"2021111804092170700_cei12740-bib-0024","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0065-2776(07)96003-4","article-title":"The expansion and maintenance of antigen-selected CD8(+) T cell clones","volume":"96","author":"Fearon","year":"2007","journal-title":"Adv Immunol"},{"key":"2021111804092170700_cei12740-bib-0025","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.4049\/jimmunol.169.6.3392","article-title":"Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation","volume":"169","author":"Dimitrova","year":"2002","journal-title":"J Immunol"},{"key":"2021111804092170700_cei12740-bib-0026","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0092-8674(00)81275-1","article-title":"Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid","volume":"85","author":"Sintchak","year":"1996","journal-title":"Cell"},{"key":"2021111804092170700_cei12740-bib-0027","first-page":"14","article-title":"Continuous alloantigen elimination \u2013 a concept for allograft tolerancer","volume":"5","author":"Olszewski","year":"2000","journal-title":"Ann Transplant"},{"key":"2021111804092170700_cei12740-bib-0028","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/j.1365-2036.2007.03466.x","article-title":"Clinical trial: switch to combined mycophenolate mofetil and minimal dose calcineurin inhibitor in stable liver transplant patients \u2013 assessment of renal and allograft function, cardiovascular risk factors and immune monitoring","volume":"26","author":"Cicinnati","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"2021111804092170700_cei12740-bib-0029","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/lt.21657","article-title":"Pharmacokinetics, efficacy, and safety of mycophenolate mofetil in combination with standard-dose or reduced-dose tacrolimus in liver transplant recipients","volume":"15","author":"Nashan","year":"2009","journal-title":"Liver Transpl"},{"key":"2021111804092170700_cei12740-bib-0030","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0091270008315317","article-title":"Pharmacokinetics of mycophenolic acid in live donor liver transplant patients vs deceased donor liver transplant patients. Pharmacokinetics of mycophenolic acid in live donor liver transplant patients vs deceased donor liver transplant patients","volume":"48","author":"Jain","year":"2008","journal-title":"J Clin Pharmacol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12740","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/184\/1\/126\/41126374\/cei12740.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/184\/1\/126\/41126374\/cei12740.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:26:30Z","timestamp":1718191590000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/184\/1\/126\/6412168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,11]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,11]]},"published-print":{"date-parts":[[2016,3,4]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12740","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,4]]},"published":{"date-parts":[[2016,1,11]]}}}