{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:46:59Z","timestamp":1777355219541,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":2056,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,5,19]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Selective immunoglobulin A (IgA) deficiency (IgAD) is the most common primary immunodeficiency in the western world. The aim of the study was to investigate the prevalence and clinical characteristics of Helicobacter pylori-infected dyspeptic patients with IgAD. Case samples were drawn from all subjects \u2265 12 years of age (n = 104729) who had undergone serum total IgA measurements during 2004\u201314 for any reason at Leumit Healthcare Services (Israel) and had serum total IgA &amp;lt; 0\u00b707 g\/l. The control group was comprised of a random sample of remaining patients with a case\u2013control ratio of 10 controls for each case. The dyspeptic diseases were identified and retrieved from Leumit Health Care Services electronic database using specific ICD-9-CM diagnostic codes. The case group included 347 subjects and the control group 3470 subjects. There were no significant differences in the prevalence of patients with dyspepsia [84 (24\u00b72%) versus 821 (23\u00b76%) for cases and controls, respectively]. Additionally, there was no difference in a proportion of dyspeptic H. pylori-positive subjects [59 (17\u00b71%) versus 524 (15\u00b71%)] between the case and control groups. Only 59 (17%) among the 347 IgAD patients underwent gastroscopy. A significantly larger proportion of case subjects experienced several forms of gastritis [13 (61\u00b79%) versus 38 (21\u00b76%), P\u2009&amp;lt;\u20090\u00b7001), duodenal ulcers [seven (33\u00b73%) versus 19 (10\u00b78%); P = 0\u00b701] and nodular lymphoid hyperplasia (NLH) [two (9\u00b75%) versus none; P = 0\u00b7011]. IgAD is not associated with increased prevalence of H. pylori-associated dyspepsia; nevertheless, H. pylori-infected dyspeptic IgAD subjects experience more EGD-proved gastritis, duodenal ulcers and NLH.<\/jats:p>","DOI":"10.1111\/cei.12765","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T13:44:33Z","timestamp":1452433473000},"page":"332-337","source":"Crossref","is-referenced-by-count":15,"title":["<i>Helicobacter pylori<\/i> infection in patients with selective immunoglobulin a deficiency"],"prefix":"10.1093","volume":"184","author":[{"given":"E","family":"Magen","sequence":"first","affiliation":[{"name":"Leumit Health Services, Ashdod, Israel"},{"name":"Clinical Immunology and Allergy Unit, Barzilai University Medical Center, Ben Gurion University of the Negev, Ashkelon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D-A","family":"Waitman","sequence":"additional","affiliation":[{"name":"Leumit Health Services, Ashdod, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Unit, Barzilai University Medical Center, Ben Gurion University of the Negev, Ashkelon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Allergy Unit, Barzilai University Medical Center, Ben Gurion University of the Negev, Ashkelon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Dickstein","sequence":"additional","affiliation":[{"name":"Leumit Health Services, Ashdod, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N R","family":"Kahan","sequence":"additional","affiliation":[{"name":"Leumit Health Services, Ashdod, Israel"},{"name":"School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"2021111804091715500_cei12765-bib-0001","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/eji.200737927","article-title":"Antibody deficiency diseases","volume":"38","author":"Pan-Hammarstr\u00f6m","year":"2008","journal-title":"Eur J Immunol"},{"key":"2021111804091715500_cei12765-bib-0002","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1182\/blood.V90.2.893","article-title":"Prevalence of selective IgA deficiency in Spain: more than we thought","volume":"90","author":"Pereira","year":"1997","journal-title":"Blood"},{"key":"2021111804091715500_cei12765-bib-0003","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1423-0410.1986.tb04851.x","article-title":"Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis","volume":"50","author":"Kanoh","year":"1986","journal-title":"Vox Sang"},{"key":"2021111804091715500_cei12765-bib-0004","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jaci.2009.10.013","article-title":"Primary immunodeficiencies: 2009 update","volume":"124","author":"Notarangelo","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"2021111804091715500_cei12765-bib-0005","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/ACI.0b013e3283594219","article-title":"IgA deficiency: what is new?","volume":"12","author":"Wang","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2021111804091715500_cei12765-bib-0006","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMcp1001110","article-title":"Clinical practice. 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