{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:15:08Z","timestamp":1785543308841,"version":"3.56.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":2043,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,15]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-AAE patients. From 2014 to 2015, 534 patients were seen at our national reference centre for angioedema and\/or urticaria. Among them, we identified 31 patients with idiopathic histaminergic acquired angioedema without wheals (IH-AAE). Thirty-one patients (15 men and 16 women) with a mean age of 50 years met the criteria for IH-AAE. The average delay in diagnosis was 6\u00b73 years. A history of allergy was found in 12 patients (38\u00b77%), nine suffering from allergic rhinitis. The mean duration of attacks was 28\u00b71 h. The AE attack was located in the upper respiratory tract in 54\u00b78% of cases (17 patients). A lingual location was found in 29% of patients. Men were more likely than women to have an upper airway involvement. No intubations or admissions to intensive care units were reported. The dosage of anti-histamines to control the symptoms was onefold the recommended dose in 51\u00b76% of patients (16 patients), twofold in 32% (10 patients) and three\u2013fourfold in 16\u00b71% (five patients). IH-AAE is characterized by an important delay in diagnosis, a frequent involvement of the upper airway and a benign course during attacks. As in CU, a trial of up to fourfold dose of H1-anti-histamines may be necessary to control symptoms.<\/jats:p>","DOI":"10.1111\/cei.12789","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T19:14:04Z","timestamp":1457810044000},"page":"81-85","source":"Crossref","is-referenced-by-count":21,"title":["Idiopathic histaminergic angioedema without wheals: a case series of 31 patients"],"prefix":"10.1093","volume":"185","author":[{"given":"C","family":"Faisant","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Grenoble University Hospital"},{"name":"Grenoble Alps University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Boccon-Gibod","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Grenoble University Hospital"},{"name":"French National Reference Centre for Angioedema 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