{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:37:55Z","timestamp":1786491475982,"version":"build-2736575974"},"reference-count":143,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,18]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Primary infection with varicella zoster virus (VZV), an exclusively human neurotrophic alphaherpsesvirus, results in varicella, known more commonly as chickenpox. Like other alphaherpesviruses, VZV establishes latency in the sensory ganglia and can reactivate to cause herpes zoster (also known as shingles), a painful and debilitating disease, especially in elderly and immunocompromised individuals. The overall incidence of herpes zoster in Europe and the United States is three per 1000 people, but increases sharply after 60 years of age to 10 per 1000 people. Zostavax\u00ae is a vaccine approved by the Federal Drug Administration for the prevention of herpes zoster. Unfortunately, this vaccine reduces the incidence of disease by only 51% and the incidence of post-herpetic neuralgia by 66\u00b75% when administered to those aged 60 and older. Moreover, it is contraindicated for individuals who are immunocompromised or receiving immunosuppressant treatments, although they are at higher risk for herpes zoster compared to immune-competent older individuals. This paper reviews VZV pathogenesis, host responses and current vaccines available to prevent herpes zoster.<\/jats:p>","DOI":"10.1111\/cei.12809","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T23:26:10Z","timestamp":1462922770000},"page":"82-92","source":"Crossref","is-referenced-by-count":22,"title":["Herpes zoster and the search for an effective vaccine"],"prefix":"10.1093","volume":"187","author":[{"given":"N","family":"Arnold","sequence":"first","affiliation":[{"name":"Graduate Program in Microbiology, University of California-Riverside, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Messaoudi","sequence":"additional","affiliation":[{"name":"Graduate Program in Microbiology, University of California-Riverside, Riverside, CA, USA"},{"name":"Division of Biomedical Sciences, School of Medicine, University of California-Riverside, Riverside, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"2021120808030704400_cei12809-bib-0001","first-page":"1","article-title":"The varicella-zoster virus genome","volume":"342","author":"Cohen","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"2021120808030704400_cei12809-bib-0002","doi-asserted-by":"crossref","first-page":"e1000971","DOI":"10.1371\/journal.ppat.1000971","article-title":"Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor","volume":"6","author":"Zhang","year":"2010","journal-title":"PLoS Pathog"},{"key":"2021120808030704400_cei12809-bib-0003","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1128\/JVI.00376-14","article-title":"The varicella-zoster virus portal protein is essential for cleavage and packaging of viral DNA","volume":"88","author":"Visalli","year":"2014","journal-title":"J 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