{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:51:50Z","timestamp":1780444310755,"version":"3.54.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":1922,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32003B_152674\/1"],"award-info":[{"award-number":["32003B_152674\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Anti-C1q antibodies (anti-C1q) have been implicated in the pathogenesis of autoimmune diseases, including autoimmune thyroid disorders (AITD). The aim of this study was to evaluate the association between anti-C1q and thyroid function in pregnancy-associated AITD. In 96 pregnant women screened positive for AITD (thyroid dysfunction and\/or antibodies against thyroperoxidase \u2013 TPOAb), anti-C1q were measured during the 9-11th gestational week and after delivery (median 16 months after delivery), and compared to the corresponding serum levels of thyroid hormones. As controls, 80 healthy pregnant women, 72 non-pregnant AITD patients and 72 blood donors were included. In the non-pregnant AITD group, two serum samples \u2265 6 months apart were analysed. Compared to blood donors, anti-C1q levels were substantially higher in all pregnant women analysed. In pregnancy, anti-C1q levels were higher in the TPOAb-positive women than in controls (37 versus 17\u00b75%, P &amp;lt; 0\u00b70001). Anti-C1q-positive pregnant women screened positive for AITD had higher thyroid-stimulating hormone (TSH) levels than anti-C1q-negative women (2\u00b741 versus 1\u00b794 mU\/l, P = 0\u00b701), and TSH correlated positively with anti-C1q (r = 0\u00b7226, P = 0\u00b7045) in the TPOAb-positive women. After delivery, serum levels of anti-C1q decreased in the positively screened TPOAb-negative women (8\u00b78 versus 5\u00b79 U\/l, P = 0\u00b7002), but not in the TPOAb-positive ones, and they no longer correlated with TSH. Anti-C1q antibody levels increase during pregnancy in general and even more in the context of AITD, where they correlate with thyroid stimulating hormone levels.<\/jats:p>","DOI":"10.1111\/cei.12813","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T15:31:25Z","timestamp":1463844685000},"page":"10-17","source":"Crossref","is-referenced-by-count":6,"title":["Anti-C1q autoantibodies are linked to autoimmune thyroid disorders in pregnant women"],"prefix":"10.1093","volume":"186","author":[{"given":"H","family":"Vitkova","sequence":"first","affiliation":[{"name":"Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Jiskra","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Springer","sequence":"additional","affiliation":[{"name":"Institute of Clinical Biochemistry and Laboratory Medicine, General University Hospital in Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Limanova","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Telicka","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bartakova","sequence":"additional","affiliation":[{"name":"Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Trendelenburg","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine and Laboratory of Clinical Immunology, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Potlukova","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, University Hospital Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"2021120807490232800_cei12813-bib-0001","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.4049\/jimmunol.178.6.3345","article-title":"Maternal acceptance of the fetus: true human tolerance","volume":"178","author":"Guleria","year":"2007","journal-title":"J Immunol"},{"key":"2021120807490232800_cei12813-bib-0002","doi-asserted-by":"crossref","first-page":"J287","DOI":"10.1016\/j.jaut.2009.11.015","article-title":"The implications of autoimmunity and pregnancy","volume":"34","author":"Borchers","year":"2010","journal-title":"J Autoimmun"},{"key":"2021120807490232800_cei12813-bib-0003","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.berh.2012.01.014","article-title":"Pregnancy and autoimmunity: a common problem","volume":"26","author":"Perricone","year":"2012","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2021120807490232800_cei12813-bib-0004","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1210\/jc.2011-3275","article-title":"Is age a risk factor for hypothyroidism in pregnancy? 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