{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:14Z","timestamp":1791405194483,"version":"4.3.3"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2011-0572"],"award-info":[{"award-number":["PICT 2011-0572"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 112-2014-0100202"],"award-info":[{"award-number":["PIP 112-2014-0100202"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,18]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>We have reported previously that T cells from patients with multi-drug-resistant tuberculosis (MDR-TB) express high levels of interleukin (IL)-17 in response to the MDR strain M (Haarlem family) of Mycobacterium tuberculosis (M. tuberculosis). Herein, we explore the pathways involved in the induction of Th17 cells in MDR-TB patients and healthy tuberculin reactors [purified protein derivative healthy donors (PPD+ HD)] by the M strain and the laboratory strain H37Rv. Our results show that IL-1\u03b2 and IL-6 are crucial for the H37Rv and M-induced expansion of IL-17+interferon (IFN)-\u03b3\u2013 and IL-17+IFN-\u03b3+ in CD4+ T cells from MDR-TB and PPD+ HD. IL-23 plays an ambiguous role in T helper type 1 (Th1) and Th17 profiles: alone, IL-23 is responsible for M. tuberculosis-induced IL-17 and IFN-\u03b3 expression in CD4+ T cells from PPD+ HD whereas, together with transforming growth factor (TGF-\u03b2), it promotes IL-17+IFN-\u03b3\u2013 expansion in MDR-TB. In fact, spontaneous and M. tuberculosis-induced TGF-\u03b2 secretion is increased in cells from MDR-TB, the M strain being the highest inducer. Interestingly, Toll-like receptor (TLR)-2 signalling mediates the expansion of IL-17+IFN-\u03b3\u2013 cells and the enhancement of latency-associated protein (LAP) expression in CD14+ and CD4+ T cells from MDR-TB, which suggests that the M strain promotes IL-17+IFN-\u03b3\u2013 T cells through a strong TLR-2-dependent TGF-\u03b2 production by antigen-presenting cells and CD4+ T cells. Finally, CD4+ T cells from MDR-TB patients infected with MDR Haarlem strains show higher IL-17+IFN-\u03b3\u2013 and lower IL-17+IFN-\u03b3+ levels than LAM-infected patients. The present findings deepen our understanding of the role of IL-17 in MDR-TB and highlight the influence of the genetic background of the infecting M. tuberculosis strain on the ex-vivo Th17 response.<\/jats:p>","DOI":"10.1111\/cei.12873","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T14:33:11Z","timestamp":1475073191000},"page":"160-173","source":"Crossref","is-referenced-by-count":25,"title":["<i>Mycobacterium tuberculosis<\/i> multi-drug-resistant strain M induces IL-17+IFN\u03b3\u2013 CD4+ T cell expansion through an IL-23 and TGF-\u03b2-dependent mechanism in patients with MDR-TB tuberculosis"],"prefix":"10.1093","volume":"187","author":[{"given":"J I","family":"Basile","sequence":"first","affiliation":[{"name":"Instituto de Medicina Experimental-CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Kviatcovsky","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Experimental-CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M M","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Experimental-CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Balboa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Experimental-CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Monteserin","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Enfermedades Infecciosas, ANLIS Carlos G. 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