{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:47Z","timestamp":1740126467691,"version":"3.37.3"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002717","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","award":["LR99ES27"],"award-info":[{"award-number":["LR99ES27"]}],"id":[{"id":"10.13039\/501100002717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis or Sj\u00f6gren's syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in-utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance. In this perspective, female Swiss albino mice were inoculated intraperitoneally or orally with the diabetogenic CV-B4 E2 strain at gestational days 10 or 17. Offspring were killed at different post-inoculation times, and their thymuses were analysed for evidence of infection and alterations in thymic T cell subsets. In-utero CV-B infection of the thymus was demonstrated during the course of vertical transmission, as attested by viral RNA and infectious virus detection in most analysed samples. No histopathological changes were evident. Thymic T cells were not depleted, despite being positive for viral RNA. As evidenced by flow cytometry analysis, CV-B infection of the fetal thymus induced significant changes of thymic T cell populations, particularly with maternal inoculation at gestational day 10. Altogether, these findings suggest that CV-B infection of the fetal thymus may play an important role in the genesis of autoimmune diseases.<\/jats:p>","DOI":"10.1111\/cei.12893","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T10:18:11Z","timestamp":1478773091000},"page":"399-407","source":"Crossref","is-referenced-by-count":8,"title":["<i>In-utero<\/i> coxsackievirus B4 infection of the mouse thymus"],"prefix":"10.1093","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-9405","authenticated-orcid":false,"given":"H","family":"Ja\u00efdane","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Monastir, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Facult\u00e9 de Pharmacie de Monastir, Monastir, Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar, Facult\u00e9 des Sciences de Tunis, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Halouani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Monastir, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Facult\u00e9 de Pharmacie de Monastir, Monastir, Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar, Facult\u00e9 des Sciences de Tunis, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Jmii","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Monastir, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Facult\u00e9 de Pharmacie de Monastir, Monastir, Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar, Facult\u00e9 des Sciences de Tunis, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Elmastour","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Monastir, Laboratoire des Maladies Transmissibles et Substances Biologiquement Actives LR99ES27, Facult\u00e9 de Pharmacie de Monastir, Monastir, Tunisia"},{"name":"Universit\u00e9 de Tunis El Manar, Facult\u00e9 des Sciences de Tunis, Tunis, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Abdelkefi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sousse, Unit\u00e9 de recherche \u2018UR06SP05\u2019, Centre R\u00e9gional de Transfusion Sanguine, H\u00f4pital Farhat Hached, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bodart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Liege, GIGA Research \u2013 Centre d'Immunologie, CHU-B34, Tilman, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Michaux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Liege, GIGA Research \u2013 Centre d'Immunologie, CHU-B34, Tilman, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Chakroun","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Sousse, Unit\u00e9 de recherche \u2018UR06SP05\u2019, Centre R\u00e9gional de Transfusion Sanguine, H\u00f4pital Farhat Hached, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sane","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lille 2, CHRU Lille, Laboratoire de Virologie EA3610, B\u00e2timent P. 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