{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:33:32Z","timestamp":1791423212115,"version":"4.3.3"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a novel PAD4-selective inhibitor, GSK199, in the murine collagen-induced arthritis model of rheumatoid arthritis. Mice were dosed daily from the time of collagen immunization with GSK199. Efficacy was assessed against a wide range of end-points, including clinical disease scores, joint histology and immunohistochemistry, serum and joint citrulline levels and quantification of synovial autoantibodies using a proteomic array containing joint peptides. Administration of GSK199 at 30 mg\/kg led to significant effects on arthritis, assessed both by global clinical disease activity and by histological analyses of synovial inflammation, pannus formation and damage to cartilage and bone. In addition, significant decreases in complement C3 deposition in both synovium and cartilage were observed robustly with GSK199 at 10 mg\/kg. Neither the total levels of citrulline measurable in joint and serum, nor levels of circulating collagen antibodies, were affected significantly by treatment with GSK199 at any dose level. In contrast, a subset of serum antibodies reactive against citrullinated and non-citrullinated joint peptides were reduced with GSK199 treatment. These data extend our previous demonstration of efficacy with the pan-PAD inhibitor Cl-amidine and demonstrate robustly that PAD4 inhibition alone is sufficient to block murine arthritis clinical and histopathological end-points.<\/jats:p>","DOI":"10.1111\/cei.12932","type":"journal-article","created":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T15:47:36Z","timestamp":1485532056000},"page":"263-274","source":"Crossref","is-referenced-by-count":108,"title":["Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis"],"prefix":"10.1093","volume":"188","author":[{"given":"V C","family":"Willis","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N K","family":"Banda","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K N","family":"Cordova","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P E","family":"Chandra","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA and the VA Palo Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W H","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA and the VA Palo Alto Health Care System, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D C","family":"Cooper","sequence":"additional","affiliation":[{"name":"Target Sciences Statistics, GlaxoSmithKline, Collegeville, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lugo","sequence":"additional","affiliation":[{"name":"Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P P","family":"Tak","sequence":"additional","affiliation":[{"name":"Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Prinjha","sequence":"additional","affiliation":[{"name":"Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H D","family":"Lewis","sequence":"additional","affiliation":[{"name":"Immuno-Inflammation Therapy Area, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V M","family":"Holers","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"2021120808031549700_cei12932-bib-0001","doi-asserted-by":"crossref","first-page":"456","DOI":"10.7326\/0003-4819-152-7-201004060-00010","article-title":"Systematic review: accuracy of anti-citrullinated peptide antibodies for diagnosing rheumatoid arthritis","volume":"152","author":"Whiting","year":"2010","journal-title":"Ann Intern Med"},{"key":"2021120808031549700_cei12932-bib-0002","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/art.11224","article-title":"Can we accurately predict the development of rheumatoid arthritis in the preclinical phase?","volume":"48","author":"Majka","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0003","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/ard.2005.040659","article-title":"Simultaneous development of acute phase response and autoantibodies in preclinical rheumatoid arthritis","volume":"65","author":"Nielen","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/ard.2006.057331","article-title":"Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis","volume":"66","author":"Rantapaa-Dahlqvist","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0005","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/art.38273","article-title":"Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis","volume":"66","author":"de Hair","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2021120808031549700_cei12932-bib-0006","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/ar95","article-title":"Citrullination: a small change for a protein with great consequences for rheumatoid arthritis","volume":"2","author":"van Venrooij","year":"2000","journal-title":"Arthritis Res"},{"key":"2021120808031549700_cei12932-bib-0007","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.gene.2003.12.038","article-title":"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6","volume":"330","author":"Chavanas","year":"2004","journal-title":"Gene"},{"key":"2021120808031549700_cei12932-bib-0008","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"2021120808031549700_cei12932-bib-0009","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1002\/art.22983","article-title":"Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation","volume":"56","author":"Foulquier","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0010","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1093\/rheumatology\/kel023","article-title":"Association between PADI4 and rheumatoid arthritis: a meta-analysis","volume":"45","author":"Iwamoto","year":"2006","journal-title":"Rheumatology (Oxf)"},{"key":"2021120808031549700_cei12932-bib-0011","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/ard.2009.111294","article-title":"PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population","volume":"69","author":"Burr","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0012","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/ard.2010.130526","article-title":"PADI4 polymorphism predisposes male smokers to rheumatoid arthritis","volume":"70","author":"Kochi","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0013","doi-asserted-by":"crossref","first-page":"27786","DOI":"10.1074\/jbc.274.39.27786","article-title":"Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3)","volume":"274","author":"Nakashima","year":"1999","journal-title":"J Biol Chem"},{"key":"2021120808031549700_cei12932-bib-0014","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature12942","article-title":"Citrullination regulates pluripotency and histone H1 binding to chromatin","volume":"507","author":"Christophorou","year":"2014","journal-title":"Nature"},{"key":"2021120808031549700_cei12932-bib-0015","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10495-006-3715-4","article-title":"Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells","volume":"11","author":"Liu","year":"2006","journal-title":"Apoptosis"},{"key":"2021120808031549700_cei12932-bib-0016","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J Cell Biol"},{"key":"2021120808031549700_cei12932-bib-0017","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1128\/MCB.01747-07","article-title":"Regulation of p53 target gene expression by peptidylarginine deiminase 4","volume":"28","author":"Li","year":"2008","journal-title":"Mol Cell Biol"},{"key":"2021120808031549700_cei12932-bib-0018","doi-asserted-by":"crossref","first-page":"20060","DOI":"10.1074\/jbc.M802940200","article-title":"Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis","volume":"283","author":"Yao","year":"2008","journal-title":"J Biol Chem"},{"key":"2021120808031549700_cei12932-bib-0019","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.4049\/jimmunol.177.3.1421","article-title":"Cutting edge: unique T cells that recognize citrullinated peptides are a feature of protein immunization","volume":"177","author":"Ireland","year":"2006","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0020","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1084\/jem.20110640","article-title":"Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells","volume":"208","author":"Ireland","year":"2011","journal-title":"J Exp Med"},{"key":"2021120808031549700_cei12932-bib-0021","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/ard.2005.049403","article-title":"Citrullination is an inflammation-dependent process","volume":"65","author":"Makrygiannakis","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0022","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2021120808031549700_cei12932-bib-0023","doi-asserted-by":"crossref","first-page":"11387","DOI":"10.1523\/JNEUROSCI.3349-06.2006","article-title":"Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation","volume":"26","author":"Mastronardi","year":"2006","journal-title":"J Neurosci"},{"key":"2021120808031549700_cei12932-bib-0024","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1182\/blood-2008-04-149039","article-title":"Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation","volume":"112","author":"Loos","year":"2008","journal-title":"Blood"},{"key":"2021120808031549700_cei12932-bib-0025","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1084\/jem.20080305","article-title":"Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation","volume":"205","author":"Proost","year":"2008","journal-title":"J Exp Med"},{"key":"2021120808031549700_cei12932-bib-0026","doi-asserted-by":"crossref","first-page":"666","DOI":"10.4049\/jimmunol.182.1.666","article-title":"Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4","volume":"182","author":"Struyf","year":"2009","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0027","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ydbio.2011.04.015","article-title":"Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability","volume":"355","author":"Lange","year":"2011","journal-title":"Dev Biol"},{"key":"2021120808031549700_cei12932-bib-0028","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J Exp Med"},{"key":"2021120808031549700_cei12932-bib-0029","doi-asserted-by":"crossref","first-page":"178ra40","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci Transl Med"},{"key":"2021120808031549700_cei12932-bib-0030","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/art.39215","article-title":"The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis","volume":"67","author":"Chang","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2021120808031549700_cei12932-bib-0031","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.20584","article-title":"The presence of citrullinated proteins is not specific for rheumatoid synovial tissue","volume":"50","author":"Vossenaar","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0032","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1021\/bi061180d","article-title":"Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization","volume":"45","author":"Luo","year":"2006","journal-title":"Biochemistry"},{"key":"2021120808031549700_cei12932-bib-0033","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cbic.200900698","article-title":"Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation","volume":"11","author":"Knuckley","year":"2010","journal-title":"Chembiochem"},{"key":"2021120808031549700_cei12932-bib-0034","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1021\/bi100363t","article-title":"Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3","volume":"49","author":"Knuckley","year":"2010","journal-title":"Biochemistry"},{"key":"2021120808031549700_cei12932-bib-0035","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.4049\/jimmunol.1001620","article-title":"N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis","volume":"186","author":"Willis","year":"2011","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0036","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nchembio.1735","article-title":"Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation","volume":"11","author":"Lewis","year":"2015","journal-title":"Nat Chem Biol"},{"key":"2021120808031549700_cei12932-bib-0037","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1002\/art.10591","article-title":"Mechanisms of effects of complement inhibition in murine collagen-induced arthritis","volume":"46","author":"Banda","year":"2002","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0038","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1002\/1529-0131(200012)43:12<2648::AID-ANR4>3.0.CO;2-M","article-title":"Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis","volume":"43","author":"Bendele","year":"2000","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0039","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.4049\/jimmunol.177.3.1904","article-title":"Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis","volume":"177","author":"Banda","year":"2006","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0040","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1046\/j.1471-4159.2002.00834.x","article-title":"Peptidylarginine deiminase: a candidate factor in demyelinating disease","volume":"81","author":"Moscarello","year":"2002","journal-title":"J Neurochem"},{"key":"2021120808031549700_cei12932-bib-0041","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(99)00276-1","article-title":"The developmental expression and activity of peptidylarginine deiminase in the mouse","volume":"266","author":"Pritzker","year":"1999","journal-title":"Neurosci Lett"},{"key":"2021120808031549700_cei12932-bib-0042","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/abio.2000.4805","article-title":"A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline","volume":"286","author":"Knipp","year":"2000","journal-title":"Anal Biochem"},{"key":"2021120808031549700_cei12932-bib-0043","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.21269","article-title":"Antigen microarray profiling of autoantibodies in rheumatoid arthritis","volume":"52","author":"Hueber","year":"2005","journal-title":"Arthritis Rheum"},{"key":"2021120808031549700_cei12932-bib-0044","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nm0302-295","article-title":"Autoantigen microarrays for multiplex characterization of autoantibody responses","volume":"8","author":"Robinson","year":"2002","journal-title":"Nat Med"},{"key":"2021120808031549700_cei12932-bib-0045","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120808031549700_cei12932-bib-0046","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120808031549700_cei12932-bib-0047","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1084\/jem.20072051","article-title":"Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice","volume":"205","author":"Hill","year":"2008","journal-title":"J Exp Med"},{"key":"2021120808031549700_cei12932-bib-0048","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/art.38393","article-title":"Peptidylarginine deiminase 4 contributes to tumor necrosis factor alpha-induced inflammatory arthritis","volume":"66","author":"Shelef","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2021120808031549700_cei12932-bib-0049","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13075-016-1068-0","article-title":"Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation","volume":"18","author":"Bawadekar","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2021120808031549700_cei12932-bib-0050","doi-asserted-by":"crossref","first-page":"R104","DOI":"10.1186\/ar3829","article-title":"PAD4 is not essential for disease in the K\/BxN murine autoantibody-mediated model of arthritis","volume":"14","author":"Rohrbach","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2021120808031549700_cei12932-bib-0051","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.1038\/srep13041","article-title":"Peptidylarginine deiminase type 4 deficiency reduced arthritis severity in a glucose-6-phosphate isomerase-induced arthritis model","volume":"5","author":"Seri","year":"2015","journal-title":"Sci Rep"},{"key":"2021120808031549700_cei12932-bib-0052","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12891-016-1055-2","article-title":"Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice","volume":"17","author":"Suzuki","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"2021120808031549700_cei12932-bib-0053","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1002\/eji.201646542","article-title":"Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation","volume":"46","author":"Papadaki","year":"2016","journal-title":"Eur J Immunol"},{"key":"2021120808031549700_cei12932-bib-0054","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0161-5890(99)00113-3","article-title":"Complement activation and inhibition in experimental models of arthritis","volume":"36","author":"Linton","year":"1999","journal-title":"Mol Immunol"},{"key":"2021120808031549700_cei12932-bib-0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0065-2776(04)82005-4","article-title":"The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease","volume":"82","author":"Monach","year":"2004","journal-title":"Adv Immunol"},{"key":"2021120808031549700_cei12932-bib-0056","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.179.6.4101","article-title":"Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway","volume":"179","author":"Banda","year":"2007","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0057","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.4049\/jimmunol.1001564","article-title":"Essential role of complement mannose-binding lectin-associated serine proteases-1\/3 in the murine collagen antibody-induced model of inflammatory arthritis","volume":"185","author":"Banda","year":"2010","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0058","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.4049\/jimmunol.1102310","article-title":"Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice","volume":"188","author":"Banda","year":"2012","journal-title":"J Immunol"},{"key":"2021120808031549700_cei12932-bib-0059","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1021\/acschembio.5b00942","article-title":"Protein arginine methylation and citrullination in epigenetic regulation","volume":"11","author":"Fuhrmann","year":"2016","journal-title":"ACS Chem Biol"},{"key":"2021120808031549700_cei12932-bib-0060","doi-asserted-by":"crossref","first-page":"26430","DOI":"10.1038\/srep26430","article-title":"Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses","volume":"6","author":"Kawalkowska","year":"2016","journal-title":"Sci Rep"},{"key":"2021120808031549700_cei12932-bib-0061","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1136\/annrheumdis-2014-205365","article-title":"Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL\/lpr mice","volume":"74","author":"Knight","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"2021120808031549700_cei12932-bib-0062","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar2089","article-title":"Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis","volume":"8","author":"Nandakumar","year":"2006","journal-title":"Arthritis Res Ther"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/188\/2\/263\/41643128\/cei12932.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/188\/2\/263\/41643128\/cei12932.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:27:44Z","timestamp":1641054464000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/188\/2\/263\/6411976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,9]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,3,9]]},"published-print":{"date-parts":[[2017,4,6]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12932","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2017,5]]},"published":{"date-parts":[[2017,3,9]]}}}