{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:03:46Z","timestamp":1783119826739,"version":"3.54.6"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The advent of next-generation sequencing (NGS) and \u2018omic\u2019 technologies has revolutionized the field of genetics, and its implementation in health care has the potential to realize precision medicine. Primary immunodeficiencies (PID) are a group of rare diseases which have benefited from NGS, with a massive increase in causative genes identified in the past few years. Common variable immunodeficiency disorders (CVID) are a heterogeneous form of PID and the most common form of antibody failure in children and adults. While a monogenic cause of disease has been identified in a small subset of CVID patients, a genomewide association study and whole genome sequencing have found that, in the majority, a polygenic cause is likely. Other NGS technologies such as RNA sequencing and epigenetic studies have contributed further to our understanding of the contribution of altered gene expression in CVID pathogenesis. We believe that to unravel further the complexities of CVID, a multi-omic approach, combining DNA sequencing with gene expression, methylation, proteomic and metabolomics data, will be essential to identify novel disease-associated pathways and therapeutic targets.<\/jats:p>","DOI":"10.1111\/cei.12947","type":"journal-article","created":{"date-parts":[[2017,2,25]],"date-time":"2017-02-25T08:08:44Z","timestamp":1488010124000},"page":"326-332","source":"Crossref","is-referenced-by-count":73,"title":["The role of genomics in common variable immunodeficiency disorders"],"prefix":"10.1093","volume":"188","author":[{"given":"A-K","family":"Kienzler","sequence":"first","affiliation":[{"name":"NIHR Oxford Biomedical Research Centre, Clinical Immunology Group, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"NIHR Oxford Biomedical Research Centre, Clinical Immunology Group, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-2208","authenticated-orcid":false,"given":"S Y","family":"Patel","sequence":"additional","affiliation":[{"name":"NIHR Oxford Biomedical Research Centre, Clinical Immunology Group, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"2021120808030927800_cei12947-bib-0001","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","article-title":"DNA sequencing with chain-terminating inhibitors","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120808030927800_cei12947-bib-0002","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.2443975","article-title":"A system for rapid DNA sequencing with fluorescent chain-terminating 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