{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:05:21Z","timestamp":1788584721370,"version":"build-2803163510"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:00:00Z","timestamp":1490918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Swedish Society for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Swedish Rheumatism Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009800","name":"Professor Nanna Svartz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006129","name":"King Gustaf V's 80-year foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Dysfunctional elimination of cell debris, and the role of opsonins such as pentraxins, is of interest regarding systemic lupus erythematosus (SLE) pathogenesis. Interferon (IFN)-\u03b1 is typically elevated during SLE flares, and inhibits hepatocyte production of the pentraxin \u2018C-reactive protein\u2019 (CRP), partly explaining the poor correlation between CRP levels and SLE disease activity. The extrahepatically produced \u2018pentraxin 3\u2019 (PTX3) shares waste disposal functions with CRP, but has not been studied extensively in SLE. We analysed serum PTX3 in SLE, and assessed its interference with IFN-\u03b1 in vitro. Serum samples from 243 patients with SLE and 100 blood donors were analysed regarding PTX3. Patient sera were analysed for IFN-\u03b1, and genotyped for three PTX3 single nucleotide polymorphisms reported previously to associate with PTX3 levels. Stimulated PTX3 release was assessed in the presence or absence of IFN-\u03b1 in blood donor neutrophils and peripheral blood mononuclear cells (PBMC). Serum PTX3 was 44% lower in patients with SLE compared to blood donors (P &amp;lt; 0\u00b70001) and correlated with leucocyte variables. Patients with undetectable IFN-\u03b1 had 29% higher median PTX3 level than patients with detectable IFN-\u03b1 (P = 0\u00b701). PTX3 production by PBMC was inhibited by IFN-\u03b1, whereas neutrophil degranulation of PTX3 was increased. No differences in PTX3 levels were observed between the SNPs. In conclusion, median serum PTX3 is lower in SLE (especially when IFN-\u03b1 is detectable) compared to blood donors. In addition to its potential consumption during waste disposal, it is plausible that IFN-\u03b1 also attenuates PTX3 by inhibiting synthesis by PBMC and\/or exhausting PTX3 storage in neutrophil granules.<\/jats:p>","DOI":"10.1111\/cei.12957","type":"journal-article","created":{"date-parts":[[2017,3,3]],"date-time":"2017-03-03T23:32:50Z","timestamp":1488583970000},"page":"83-91","source":"Crossref","is-referenced-by-count":19,"title":["Interferon-\u03b1 coincides with suppressed levels of pentraxin-3 (PTX3) in systemic lupus erythematosus and regulates leucocyte PTX3 <i>in vitro<\/i>"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-8344","authenticated-orcid":false,"given":"L","family":"Wirestam","sequence":"first","affiliation":[{"name":"Rheumatology\/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2125-2931","authenticated-orcid":false,"given":"H","family":"Enocsson","sequence":"additional","affiliation":[{"name":"Rheumatology\/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-9249","authenticated-orcid":false,"given":"T","family":"Skogh","sequence":"additional","affiliation":[{"name":"Rheumatology\/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-1351","authenticated-orcid":false,"given":"M L","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Rheumatology, Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-6503","authenticated-orcid":false,"given":"L","family":"R\u00f6nnblom","sequence":"additional","affiliation":[{"name":"Rheumatology, Department of Medical Sciences, Science for Life Laboratory, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-2048","authenticated-orcid":false,"given":"C","family":"Sj\u00f6wall","sequence":"additional","affiliation":[{"name":"Rheumatology\/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6916-5490","authenticated-orcid":false,"given":"J","family":"Wetter\u00f6","sequence":"additional","affiliation":[{"name":"Rheumatology\/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,31]]},"reference":[{"key":"2021120808102548600_cei12957-bib-0001","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/joim.12529","article-title":"Systemic lupus erythematosus: still a challenge for physicians","volume":"281","author":"Bengtsson","year":"2017","journal-title":"J Intern Med"},{"key":"2021120808102548600_cei12957-bib-0002","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0198-8859(02)00757-7","article-title":"The natural interferon-alpha producing cells in systemic lupus erythematosus","volume":"63","author":"Ronnblom","year":"2002","journal-title":"Hum Immunol"},{"key":"2021120808102548600_cei12957-bib-0003","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/art.37821","article-title":"Disease mechanisms in rheumatology \u2013 tools and pathways: plasmacytoid dendritic cells and their role in autoimmune rheumatic diseases","volume":"65","author":"Eloranta","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0004","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/art.21556","article-title":"Prevention and reversal of nephritis in MRL\/lpr mice with a single injection of C-reactive protein","volume":"54","author":"Rodriguez","year":"2006","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0005","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/art.11026","article-title":"Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene","volume":"48","author":"Szalai","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0006","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1191\/0961203305lu2157oa","article-title":"High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk","volume":"14","author":"Barnes","year":"2005","journal-title":"Lupus"},{"key":"2021120808102548600_cei12957-bib-0007","first-page":"815","article-title":"Absence of correlation between interleukin 6 and C-reactive protein blood levels in systemic lupus erythematosus compared with rheumatoid arthritis","volume":"20","author":"Gabay","year":"1993","journal-title":"J Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0008","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1177\/0961203311418706","article-title":"Is there any correlation between high sensitive CRP and disease activity in systemic lupus erythematosus?","volume":"20","author":"Rezaieyazdi","year":"2011","journal-title":"Lupus"},{"key":"2021120808102548600_cei12957-bib-0009","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12879-015-1272-6","article-title":"Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia","volume":"15","author":"Lubell","year":"2015","journal-title":"BMC Infect Dis"},{"key":"2021120808102548600_cei12957-bib-0010","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1002\/art.25042","article-title":"Interferon-alpha mediates suppression of C-reactive protein: explanation for muted C-reactive protein response in lupus flares?","volume":"60","author":"Enocsson","year":"2009","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0011","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/art.38408","article-title":"Association of serum C-reactive protein levels with lupus disease activity in the absence of measurable interferon-alpha and a C-reactive protein gene variant","volume":"66","author":"Enocsson","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0012","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.coi.2008.05.004","article-title":"Pentraxins, humoral innate immunity and tissue injury","volume":"20","author":"Manfredi","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"2021120808102548600_cei12957-bib-0013","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1074\/jbc.M708535200","article-title":"Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization","volume":"283","author":"Inforzato","year":"2008","journal-title":"J Biol Chem"},{"key":"2021120808102548600_cei12957-bib-0014","doi-asserted-by":"crossref","first-page":"17681","DOI":"10.1074\/jbc.M109.085639","article-title":"The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2","volume":"285","author":"Inforzato","year":"2010","journal-title":"J Biol Chem"},{"key":"2021120808102548600_cei12957-bib-0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cellimm.2007.09.003","article-title":"Lipopolysaccharide induced expression of pentraxin 3 in human neutrophils and monocyte-derived macrophages","volume":"248","author":"Imamura","year":"2007","journal-title":"Cell Immunol"},{"key":"2021120808102548600_cei12957-bib-0016","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<496::AID-IMMU496>3.0.CO;2-V","article-title":"Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes","volume":"28","author":"Polentarutti","year":"1998","journal-title":"Eur J Immunol"},{"key":"2021120808102548600_cei12957-bib-0017","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1084\/jem.20061301","article-title":"The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps","volume":"204","author":"Jaillon","year":"2007","journal-title":"J Exp Med"},{"key":"2021120808102548600_cei12957-bib-0018","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1002\/eji.200324390","article-title":"Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells","volume":"33","author":"Doni","year":"2003","journal-title":"Eur J Immunol"},{"key":"2021120808102548600_cei12957-bib-0019","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.semarthrit.2008.03.006","article-title":"The long pentraxin 3 and its role in autoimmunity","volume":"39","author":"Ortega-Hernandez","year":"2009","journal-title":"Semin Arthritis Rheumat"},{"key":"2021120808102548600_cei12957-bib-0020","doi-asserted-by":"crossref","first-page":"e53030","DOI":"10.1371\/journal.pone.0053030","article-title":"Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels","volume":"7","author":"Barbati","year":"2012","journal-title":"PLoS One"},{"key":"2021120808102548600_cei12957-bib-0021","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1164\/rccm.201204-0692OC","article-title":"Variation in PTX3 is associated with primary graft dysfunction after lung transplantation","volume":"186","author":"Diamond","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"2021120808102548600_cei12957-bib-0022","doi-asserted-by":"crossref","DOI":"10.2119\/molmed.2016.00002","article-title":"The clearance of cell remnants and the regeneration of the injured muscle depend on soluble pattern recognition receptor PTX3","volume":"22","author":"Vezzoli","year":"2016","journal-title":"Mol Med"},{"key":"2021120808102548600_cei12957-bib-0023","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1084\/jem.20141268","article-title":"An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode","volume":"212","author":"Doni","year":"2015","journal-title":"J Exp Med"},{"key":"2021120808102548600_cei12957-bib-0024","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/ATVBAHA.111.243998","article-title":"Long pentraxin 3\/tumor necrosis factor-stimulated gene-6 interaction: a biological rheostat for fibroblast growth factor 2-mediated angiogenesis","volume":"32","author":"Leali","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2021120808102548600_cei12957-bib-0025","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1242\/dev.01056","article-title":"PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization","volume":"131","author":"Salustri","year":"2004","journal-title":"Development"},{"key":"2021120808102548600_cei12957-bib-0026","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1189\/jlb.0905493","article-title":"Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma","volume":"79","author":"Doni","year":"2006","journal-title":"J Leukocyte Biol"},{"key":"2021120808102548600_cei12957-bib-0027","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/14397595.2013.852837","article-title":"Pentraxin 3 is associated with disease activity but not atherosclerosis in patients with systemic lupus erythematosus","volume":"24","author":"Shimada","year":"2014","journal-title":"Mod Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0028","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/08916934.2014.983264","article-title":"Pentraxin 3 as a biomarker of local inflammatory response to vascular injury in systemic lupus erythematosus","volume":"48","author":"Cieslik","year":"2015","journal-title":"Autoimmunity"},{"key":"2021120808102548600_cei12957-bib-0029","first-page":"354014","article-title":"Pentraxin 3 plasma levels and disease activity in systemic lupus erythematosus","volume":"2015","author":"Assandri","year":"2015","journal-title":"Autoimmune Dis"},{"key":"2021120808102548600_cei12957-bib-0030","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s12016-015-8476-9","article-title":"PTX3, anti-PTX3, and anti-C1q autoantibodies in lupus glomerulonephritis","volume":"49","author":"Bassi","year":"2015","journal-title":"Clin Rev Allergy Immunol"},{"key":"2021120808102548600_cei12957-bib-0031","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1002\/1529-0131(200112)44:12<2841::AID-ART472>3.0.CO;2-6","article-title":"PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation","volume":"44","author":"Fazzini","year":"2001","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0032","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/acr.20094","article-title":"Increased levels of serum pentraxin 3, a novel cardiovascular biomarker, in patients with inflammatory rheumatic disease","volume":"62","author":"Hollan","year":"2010","journal-title":"Arthritis Care Res"},{"key":"2021120808102548600_cei12957-bib-0033","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13075-015-0521-9","article-title":"Application of the 2012 Systemic Lupus International Collaborating Clinics classification criteria to patients in a regional Swedish systemic lupus erythematosus register","volume":"17","author":"Ighe","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"2021120808102548600_cei12957-bib-0034","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0035","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0036","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman","year":"2002","journal-title":"J Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0037","first-page":"582","article-title":"A simple index to assess disease activity in rheumatoid arthritis","volume":"20","author":"Scott","year":"1993","journal-title":"J Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0038","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/art.1780390303","article-title":"The development and initial validation of the Systemic Lupus International Collaborating Clinics\/American College of Rheumatology damage index for systemic lupus erythematosus","volume":"39","author":"Gladman","year":"1996","journal-title":"Arthritis Rheum"},{"key":"2021120808102548600_cei12957-bib-0039","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/jaut.1998.0215","article-title":"Patients with systemic lupus erythematosus have reduced numbers of circulating natural interferon-alpha- producing cells","volume":"11","author":"Cederblad","year":"1998","journal-title":"J Autoimmun"},{"key":"2021120808102548600_cei12957-bib-0040","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/gene.2010.41","article-title":"PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients","volume":"11","author":"Chiarini","year":"2010","journal-title":"Genes Immun"},{"key":"2021120808102548600_cei12957-bib-0041","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nrrheum.2011.37","article-title":"C-reactive protein in rheumatology: biology and genetics","volume":"7","author":"Rhodes","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0042","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/ddh021","article-title":"Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus","volume":"13","author":"Russell","year":"2004","journal-title":"Hum Mol Genet"},{"key":"2021120808102548600_cei12957-bib-0043","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/clin.1994.1005","article-title":"Decreased autoantibody levels and enhanced survival of (NZB x NZW) F1 mice treated with C-reactive protein","volume":"70","author":"Du Clos","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"2021120808102548600_cei12957-bib-0044","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jaut.2016.07.002","article-title":"Immunization with pentraxin 3 (PTX3) leads to anti-PTX3 antibody production and delayed lupus-like nephritis in NZB\/NZW F1 mice","volume":"74","author":"Gatto","year":"2016","journal-title":"J Autoimmun"},{"key":"2021120808102548600_cei12957-bib-0045","doi-asserted-by":"crossref","first-page":"e2520","DOI":"10.1097\/MD.0000000000002520","article-title":"Pentraxin 3 is closely associated with tubulointerstitial injury in lupus nephritis: a large multicenter cross-sectional study","volume":"95","author":"Pang","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2021120808102548600_cei12957-bib-0046","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1189\/jlb.0608345","article-title":"Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6","volume":"86","author":"Maina","year":"2009","journal-title":"J Leukocyte Biol"},{"key":"2021120808102548600_cei12957-bib-0047","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/CCLM.2009.110","article-title":"Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations","volume":"47","author":"Yamasaki","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"2021120808102548600_cei12957-bib-0048","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2249.1997.269-ce1161.x","article-title":"Effects of interferon-alpha (IFN-alpha) administration on leucocytes in healthy humans","volume":"107","author":"Corssmit","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"2021120808102548600_cei12957-bib-0049","doi-asserted-by":"crossref","first-page":"73ra20","DOI":"10.1126\/scitranslmed.3001201","article-title":"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus","volume":"3","author":"Garcia-Romo","year":"2011","journal-title":"Sci Transl Med"},{"key":"2021120808102548600_cei12957-bib-0050","article-title":"Pentraxin 3 in serum and synovial fluid of patients with rheumatoid arthritis with and without autoantibodies","author":"Weitoft","year":"2016","journal-title":"Scand J Rheumatol"},{"key":"2021120808102548600_cei12957-bib-0051","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/ard.2009.117804","article-title":"IgG anti-pentraxin 3 antibodies in systemic lupus erythematosus","volume":"69","author":"Bassi","year":"2010","journal-title":"Ann Rheumat Dis"},{"key":"2021120808102548600_cei12957-bib-0052","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jaut.2002.0608","article-title":"Autoantibodies to C-reactive protein is a common finding in SLE, but not in primary Sjogren's syndrome, rheumatoid arthritis or inflammatory bowel disease","volume":"19","author":"Sjowall","year":"2002","journal-title":"J Autoimmun"},{"key":"2021120808102548600_cei12957-bib-0053","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/08916934.2013.764992","article-title":"C-reactive protein, immunoglobulin G and complement co-localize in renal immune deposits of proliferative lupus nephritis","volume":"46","author":"Sjowall","year":"2013","journal-title":"Autoimmunity"},{"key":"2021120808102548600_cei12957-bib-0054","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1191\/096120300674499064","article-title":"Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies","volume":"9","author":"Bengtsson","year":"2000","journal-title":"Lupus"},{"key":"2021120808102548600_cei12957-bib-0055","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"Baechler","year":"2003","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.12957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/189\/1\/83\/41643537\/cei12957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/189\/1\/83\/41643537\/cei12957.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:27:50Z","timestamp":1641054470000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/189\/1\/83\/6412431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,31]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,3,31]]},"published-print":{"date-parts":[[2017,6,6]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.12957","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,3,31]]}}}