{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:06:41Z","timestamp":1774670801842,"version":"3.50.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T00:00:00Z","timestamp":1494374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006710","name":"Wayne State University Perinatal Initiative in Maternal, Perinatal and Child Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,13]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Preterm birth, the leading cause of neonatal morbidity and mortality worldwide, is frequently preceded by spontaneous preterm labour, a syndrome of multiple aetiologies. Pathological inflammation is causally linked to spontaneous preterm labour. Indeed, direct activation of invariant natural killer T (iNKT) cells via \u03b1-galactosylceramide induces preterm labour\/birth largely by initiating systemic and local (i.e. decidua and myometrium) innate immune responses. Herein, we investigated whether iNKT-cell activation altered local and systemic T-cell subsets. Administration of \u03b1-galactosylceramide induced an expansion of activated CD1d-restricted iNKT cells in the decidua and a reduction in the number of: (1) total T cells (conventional CD4+ and CD8+ T cells) through the down-regulation of the CD3\u025b molecule in the peripheral circulation, spleen, uterine-draining lymph nodes (ULNs), decidua and\/or myometrium; (2) CD4+ regulatory T cells in the spleen, ULNs and decidua; (3) T helper type 17 (Th17) cells in the ULNs but an increase in the number of decidual Th17 cells; (4) CD8+ regulatory T cells in the spleen and ULNs; and (5) CD4+ and CD8+ forkhead box protein 3 negative (Foxp3\u2013) responder T cells in the spleen and ULNs. As treatment with rosiglitazone prevents iNKT-cell activation-induced preterm labour\/birth, we also explored whether the administration of this peroxisome proliferator-activated receptor gamma (PPAR\u03b3) agonist would restore the number of T cells. Treating \u03b1-galactosylceramide-injected mice with rosiglitazone partially restored the number of T cells in the spleen but not in the decidua. In summary, iNKT-cell activation altered the systemic and local T-cell subsets prior to preterm labour\/birth; however, treatment with rosiglitazone partially reversed such effects.<\/jats:p>","DOI":"10.1111\/cei.12968","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T22:36:21Z","timestamp":1491345381000},"page":"211-225","source":"Crossref","is-referenced-by-count":37,"title":["<i>In vivo<\/i>activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-5262","authenticated-orcid":false,"given":"N","family":"Gomez-Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"},{"name":"Department of Immunology & Microbiology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Epidemiology & Biostatistics, Michigan State University, East Lansing, MI, USA"},{"name":"Center for Molecular Medicine & Genetics, Wayne State University, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Arenas-Hernandez","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"},{"name":"Department of Molecular Biomedicine, CINVESTAV, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Schwenkel","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"St Louis","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T N","family":"Mial","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, NICHD\/NIH\/DHHS, Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics & Gynecology, Wayne State University, School of Medicine, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,5,10]]},"reference":[{"key":"2021120808182567400_cei12968-bib-0001","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and 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