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Fibroblast-like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA. An increasing body of evidence suggests that these cells play not only an important role in chronic inflammation and synovial hyperplasia, but also impact bone remodelling. Under inflammatory conditions FLS release inflammatory cytokines, regulate bone destruction and formation and communicate with immune cells to control bone homeostasis. Other stromal cells, such as osteoblasts and terminally differentiated osteoblasts, termed osteocytes, are also involved in the regulation of bone homeostasis and are dysregulated during inflammation. This review highlights our current understanding of how stromal cells influence the balance between bone formation and bone destruction. Increasing our understanding of these processes is critical to enable the development of novel therapeutic strategies with which to treat bone loss in RA.<\/jats:p>","DOI":"10.1111\/cei.12979","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T15:52:46Z","timestamp":1492444366000},"page":"1-11","source":"Crossref","is-referenced-by-count":45,"title":["The role of stromal cells in inflammatory bone loss"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-5153","authenticated-orcid":false,"given":"C","family":"Wehmeyer","sequence":"first","affiliation":[{"name":"Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Pap","sequence":"additional","affiliation":[{"name":"Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C D","family":"Buckley","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Naylor","sequence":"additional","affiliation":[{"name":"Institute of Inflammation and Ageing (IIA), University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"2021120808112196300_cei12979-bib-0001","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/1529-0131(200012)43:12<2619::AID-ANR1>3.0.CO;2-V","article-title":"The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue 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Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha","volume":"146","author":"Alvaro-Gracia","year":"1991","journal-title":"J Immunol"},{"key":"2021120808112196300_cei12979-bib-0056","first-page":"449","article-title":"Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha","volume":"73","author":"Buchan","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"2021120808112196300_cei12979-bib-0057","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/art.1780331204","article-title":"Role of cytokines in inflammatory synovitis. 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