{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:24:43Z","timestamp":1792797883360,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Medical Faculty of Tuebingen University","award":["F 1275151"],"award-info":[{"award-number":["F 1275151"]}]},{"DOI":"10.13039\/100009139","name":"German Center for Infection Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal\u2013fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.<\/jats:p>","DOI":"10.1111\/cei.13059","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T08:02:37Z","timestamp":1506758557000},"page":"328-337","source":"Crossref","is-referenced-by-count":58,"title":["Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period"],"prefix":"10.1093","volume":"191","author":[{"given":"J","family":"Schwarz","sequence":"first","affiliation":[{"name":"Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Scheckenbach","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kugel","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Spring","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pagel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Clinic Schleswig Holstein, Campus L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"H\u00e4rtel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pauluschke-Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Peter","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD), Tuebingen, Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tuebingen, Tuebingen, Germany"},{"name":"Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Tuebingen University Hospital, Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C F","family":"Poets","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Tuebingen University Children's Hospital, Tuebingen, 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