{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:27:58Z","timestamp":1740126478097,"version":"3.37.3"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,10,26]],"date-time":"2017-10-26T00:00:00Z","timestamp":1508976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006260","name":"Rheumatology Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006260","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Cytokine storm syndromes are a clinically heterogeneous group of conditions resulting from a maladaptive host response to an inflammatory trigger. These syndromes lead to rapid progression of immune-mediated damage to healthy tissues resulting in life-threatening multi-system organ failure. Prompt recognition of disease and medical intervention to limit damage to healthy tissues is essential to prevent cytokine storm morbidity and mortality. However, the diagnosis of cytokine storm syndromes is challenging, given the clinical heterogeneity in disease presentations. Therefore, expeditious and readily available tests to diagnose disease and differentiate between the various types of cytokine storm syndromes are of clinical utility. The recently published work of Shimizu and colleagues brings us closer to making this a reality.<\/jats:p>","DOI":"10.1111\/cei.13063","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:20:19Z","timestamp":1507112419000},"page":"253-254","source":"Crossref","is-referenced-by-count":1,"title":["Combining multiple biomarkers differentiates between active SJIA, SJIA-MAS and EBV-HLH"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-091X","authenticated-orcid":false,"given":"L K","family":"Weaver","sequence":"first","affiliation":[{"name":"Instructor in Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"2021120808193200100_cei13063-bib-0001","first-page":"459","article-title":"The incidence of macrophage activation syndrome in children with rheumatic disorders","volume":"63","author":"Moradinejad","year":"2011","journal-title":"Minerva Pediatr"},{"key":"2021120808193200100_cei13063-bib-0002","first-page":"1133","article-title":"Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis","volume":"34","author":"Behrens","year":"2007","journal-title":"J Rheumatol"},{"key":"2021120808193200100_cei13063-bib-0003","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/annrheumdis-2015-208982","article-title":"Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a European league against Rheumatism\/American College of Rheumatology\/Paediatric Rheumatology international trials organisation collaborative initiative","volume":"75","author":"Ravelli","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"2021120808193200100_cei13063-bib-0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40674-017-0059-x","article-title":"Weathering the storm: improving therapeutic interventions for cytokine storm syndromes by targeting disease pathogenesis","volume":"3","author":"Weaver","year":"2017","journal-title":"Curr Treatm Opt Rheumatol"},{"key":"2021120808193200100_cei13063-bib-0005","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/cei.13026","article-title":"Characteristic elevation of soluble TNF receptor II: I ratio in macrophage activation syndrome with systemic juvenile idiopathic arthritis","volume":"191","author":"Shimizu","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"2021120808193200100_cei13063-bib-0006","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clim.2015.06.005","article-title":"Interleukin-18 for predicting the development of macrophage activation syndrome in systemic juvenile idiopathic arthritis","volume":"160","author":"Shimizu","year":"2015","journal-title":"Clin Immunol"},{"key":"2021120808193200100_cei13063-bib-0007","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/annrheumdis-2015-209020","article-title":"Elevated circulating levels of interferon-gamma and interferon-gamma-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis","volume":"76","author":"Bracaglia","year":"2016","journal-title":"Ann Rheum Dis"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/191\/3\/253\/41644498\/cei13063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/191\/3\/253\/41644498\/cei13063.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:25:44Z","timestamp":1641054344000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/191\/3\/253\/6412308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,26]]},"published-print":{"date-parts":[[2018,2,7]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13063","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"type":"print","value":"0009-9104"},{"type":"electronic","value":"1365-2249"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2017,10,26]]}}}