{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:15:43Z","timestamp":1783466143638,"version":"3.55.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP6-2005-FOOD-4B-36383"],"award-info":[{"award-number":["FP6-2005-FOOD-4B-36383"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian National Research Funds","award":["OTKA 101788"],"award-info":[{"award-number":["OTKA 101788"]}]},{"name":"Hungarian National Research Funds","award":["NKFI 120392"],"award-info":[{"award-number":["NKFI 120392"]}]},{"name":"Hungarian National Research Funds","award":["GINOP 2.3.2-15-2016-00015"],"award-info":[{"award-number":["GINOP 2.3.2-15-2016-00015"]}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008382","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>In coeliac disease (CD), anti-tissue transglutaminase 2 immunoglobulin (Ig)A antibodies (anti-TG2) are produced and deposited in the intestine. PreventCD (www.preventcd.com) is a European multi-centre study, which investigates the influence of infant nutrition and that of genetic, immunological and other environmental factors on the risk of developing CD. The aim of the current study was to evaluate the appearance of intestinal anti-TG2 deposits in very early intestinal biopsies from at-risk infants and their predictive value for villous atrophy. Sixty-five small bowel biopsies, performed in 62 children, were investigated for the presence of intestinal anti-TG2 extracellular IgA deposits by using double immunofluorescence. The biopsies were performed in the presence of elevated serum levels of CD-associated antibodies and\/or symptoms suggesting disease. Deposits of anti-TG2 IgA were present in 53 of 53 CD patients and three of three potential CD patients. In potential CD patients, mucosal deposits showed a patchy distribution characterized by some areas completely negative, whereas active CD patients had uniformly present and evident mucosal deposits. Only one of six patients without CD (negative for serum anti-TG2 and with normal mucosa) had intestinal deposits with a patchy distribution and a weak staining. Two of the 53 CD patients received a definitive diagnosis of CD after a second or third biopsy; mucosal deposits of anti-TG2 IgA were evaluated in all samples. Before developing villous atrophy, both patients had anti-TG2 deposits in normal mucosal architecture, antibodies in one patient being absent in serum. We demonstrated that in CD the intestinal deposits of anti-TG2 are a constant presence and appear very early in the natural history of disease.<\/jats:p>","DOI":"10.1111\/cei.13078","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:50:11Z","timestamp":1510131011000},"page":"311-317","source":"Crossref","is-referenced-by-count":29,"title":["Intestinal anti-transglutaminase 2 immunoglobulin A deposits in children at risk for coeliac disease (CD): data from the PreventCD study"],"prefix":"10.1093","volume":"191","author":[{"given":"M","family":"Borrelli","sequence":"first","affiliation":[{"name":"Department of Medical Translational Science, Section of Paediatrics, University Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-3779","authenticated-orcid":false,"given":"M","family":"Maglio","sequence":"additional","affiliation":[{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I R","family":"Korponay-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Debrecen Medical School, Debrecen"},{"name":"Institute of Pathology, Heim P\u00e1l Children's Hospital, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Vass","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Heim P\u00e1l Children's Hospital, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Mearin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Leiden University Medical Center, Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Niv-Drori","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Rabin Medical Center-Beilinson Hospital, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Ribes-Koninckx","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedad Cel\u00edaca e Inmunopatolog\u00eda Digestiva, Medical Research Institute La Fe, Valencia, Spain"},{"name":"Pediatric Gastrohepatology Unit, University Hospital La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Roca","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedad Cel\u00edaca e Inmunopatolog\u00eda Digestiva, Medical Research Institute La Fe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Shamir","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Nutrition and Liver Diseases Schneider Children's Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Medical Translational Science, Section of Paediatrics, University Federico II, Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Medical Translational Science, Section of Paediatrics, University Federico II, Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"2021120808201041600_cei13078-bib-0001","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2021120808201041600_cei13078-bib-0002","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"Dieterich","year":"1997","journal-title":"Nat Med"},{"key":"2021120808201041600_cei13078-bib-0003","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/MPG.0b013e318216f2e5","article-title":"Accuracy of 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