{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:26:39Z","timestamp":1790429199140,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T00:00:00Z","timestamp":1515369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["59212102"],"award-info":[{"award-number":["59212102"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","award":["2560A10301042"],"award-info":[{"award-number":["2560A10301042"]}],"id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Oral lichen planus (OLP) is considered a chronic inflammatory immune-mediated disease of the oral mucosa. Immunopathogenesis of OLP is thought to be associated with cell-mediated immune dysregulation. O-GlcNAcylation is a form of reversible glycosylation. It has been demonstrated that O-GlcNAcylation promoted nuclear factor kappa B (NF-\u03baB) signalling. Activation of NF-\u043aB can induce expression of nucleotide-binding domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, which is a large intracellular multi-protein complex involving an immune response. Dysregulated expression of the NLRP3 inflammasome was reported to be associated with autoinflammatory diseases. No integrative studies between O-GlcNAcylation and NLRP3 inflammasome in OLP patients have been reported. The present study aimed to determine the immunohistochemical expression of O-GlcNAcylation, NF-\u03baB signalling molecules and NLRP3 inflammasome in oral mucosae of OLP patients. Oral tissue samples were collected from 30 OLP patients and 30 healthy individuals. Immunohistochemical staining and analyses of immunostaining scores were performed to evaluate expression of O-GlcNAcylation, NF-\u03baB signalling molecules and NLRP3 inflammasome. According to observations in this study, significantly higher levels of O-GlcNAcylation, NF-\u03baB signalling molecules and NLRP3 inflammasome were demonstrated in OLP patients compared with control subjects (P &amp;lt; 0\u00b7001). Positive correlations among O-GlcNAcylation, NF-\u03baB signalling molecules and NLRP3 inflammasome were also observed in OLP samples (P &amp;lt; 0\u00b701). In conclusion, the present study provides supportive evidence that increased O-GlcNAcylation is associated with increased expression of NLRP3 inflammasome via the NF-\u03baB signalling pathway. These findings provide a new perspective on immunopathogenesis of OLP in relation to autoinflammation.<\/jats:p>","DOI":"10.1111\/cei.13091","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T22:20:49Z","timestamp":1513462849000},"page":"129-137","source":"Crossref","is-referenced-by-count":26,"title":["New evidence of connections between increased O-GlcNAcylation and inflammasome in the oral mucosa of patients with oral lichen planus"],"prefix":"10.1093","volume":"192","author":[{"given":"T","family":"Thi Do","sequence":"first","affiliation":[{"name":"Department of Oral Diagnosis, Faculty of Dentistry, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Research Group of Chronic Inflammatory Oral Diseases and Systemic Diseases Associated with Oral Health, Khon Kaen University, Khon Kaen, Thailand"},{"name":"Department of Oral Pathology and Periodontology, Faculty of Dentistry, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Phoomak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Research Group for Glycosciences and Glycotechnology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Champattanachai","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Silsirivanit","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Research Group for Glycosciences and Glycotechnology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 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